Regulation of microRNA biogenesis

MicroRNAs: Target Recognition and Regulatory Functions

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Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works

The nuclear RNase III Drosha initiates microRNA processing

Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,094 · see citing works

Role for a bidentate ribonuclease in the initiation step of RNA interference

Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,896 · see citing works

The widespread regulation of microRNA biogenesis, function and decay

Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672 · see citing works

miRBase: annotating high confidence microRNAs using deep sequencing data

Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 4,629 · see citing works

MicroRNA genes are transcribed by RNA polymerase II

Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,355 · see citing works

miRBase: tools for microRNA genomics

Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,349 · see citing works

Biogenesis of small RNAs in animals

Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 3,181 · see citing works

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint

Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,020 · see citing works

Processing of primary microRNAs by the Microprocessor complex

Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784 · see citing works

The Microprocessor complex mediates the genesis of microRNAs

Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T. P., Doratotaj, B., Cooch, N. S., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,724 · see citing works

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in <i>Caenorhabditis elegans</i>

Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 2,713 · see citing works

Nuclear Export of MicroRNA Precursors

Lund, E., Güttinger, S., Calado, Â., Dahlberg, J. E., & Kutay, U. (2003) · Science · doi:10.1126/science.1090599 · Cited by 2,705 · see citing works

Functional siRNAs and miRNAs exhibit strand bias

Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645 · see citing works

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,568 · see citing works

MicroRNA maturation: stepwise processing and subcellular localization

Lee, Y., Jeon, K., Lee, J., Kim, S., & Kim, V. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf476 · Cited by 2,468 · see citing works

A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia

Calin, G. A., Ferracin, M., Cimmino, A., Leva, G. D., Shimizu, M., Wojcik, S. E., Iorio, M. V., Visone, R., Sever, N. İ., Fabbri, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050995 · Cited by 2,403 · see citing works

Argonaute2 is the catalytic engine of mammalian RNAi

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,353 · see citing works

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339 · see citing works

Asymmetry in the Assembly of the RNAi Enzyme Complex

Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N., & Zamore, P. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00759-1 · Cited by 2,323 · see citing works

Small silencing RNAs: an expanding universe

Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,314 · see citing works

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the <i>let-7</i> Small Temporal RNA

Hutvágner, G., McLachlan, J., Pasquinelli, A. E., Bálint, E., Tuschl, T., & Zamore, P. D. (2001) · Science · doi:10.1126/science.1062961 · Cited by 2,287 · see citing works

Origin, Biogenesis, and Activity of Plant MicroRNAs

Voinnet, O. (2009) · Cell · doi:10.1016/j.cell.2009.01.046 · Cited by 2,215 · see citing works

The Drosha-DGCR8 complex in primary microRNA processingPreprint

Han, J., Lee, Y., Yeom, K.-H., Kim, Y. K., Jin, H., & Kim, V. N. (2004) · Genes & Development · doi:10.1101/gad.1262504 · Cited by 2,208 · see citing works

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J. A., Cooch, N. S., Nishikura, K., & Shiekhattar, R. (2005) · Nature · doi:10.1038/nature03868 · Cited by 2,103 · see citing works

Dicer is essential for mouse development

Bernstein, E., Kim, S. Y., Carmell, M., Murchison, E., Alcorn, H. L., Li, M. Z., Mills, A., Elledge, S., Anderson, K., & Hannon, G. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 2,100 · see citing works

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

Cai, X., Hagedorn, C. H., & Cullen, B. R. (2004) · RNA · doi:10.1261/rna.7135204 · Cited by 1,874 · see citing works

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 1,718 · see citing works

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

Grishok, A., Pasquinelli, A. E., Conte, D., Li, N., Parrish, S., Ha, I., Baillie, D. L., Fire, A., Ruvkun, G., & Mello, C. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00431-7 · Cited by 1,600 · see citing works

Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

Ventura, A., Young, A. G., Winslow, M. M., Lintault, L., Meissner, A., Erkeland, S. J., Newman, J. J., Bronson, R. T., Crowley, D. G., Stone, J. R., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.019 · Cited by 1,592 · see citing works

Genetic and Functional Diversification of Small RNA Pathways in Plants

Xie, Z., Johansen, L. K., Gustafson, A. M., Kasschau, K. D., Lellis, A. D., Zilberman, D., Jacobsen, S. E., & Carrington, J. C. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020104 · Cited by 1,569 · see citing works

Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex

Han, J., Lee, Y., Yeom, K., Nam, J., Heo, I., Rhee, J., Sohn, S. Y., Cho, Y., Zhang, B.-T., & Kim, V. N. (2006) · Cell · doi:10.1016/j.cell.2006.03.043 · Cited by 1,552 · see citing works

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in <i>C. elegans</i>

Ketting, R. F., Fischer, S. E. J., Bernstein, E., Sijen, T., Hannon, G. J., & Plasterk, R. H. A. (2001) · Genes &amp; Development · doi:10.1101/gad.927801 · Cited by 1,527 · see citing works

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,465 · see citing works

Intronic microRNA precursors that bypass Drosha processing

Ruby, J. G., Jan, C. H., & Bartel, D. P. (2007) · Nature · doi:10.1038/nature05983 · Cited by 1,445 · see citing works

Selective Blockade of MicroRNA Processing by Lin28

Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,442 · see citing works

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Bohnsack, M. T., Czaplinski, K., & Görlich, D. (2004) · RNA · doi:10.1261/rna.5167604 · Cited by 1,436 · see citing works

The let-7 family of microRNAs

Roush, S. F., & Slack, F. J. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.007 · Cited by 1,332 · see citing works

PIWI-interacting small RNAs: the vanguard of genome defence

Siomi, M. C., Sato, K., Pezic, D., & Aravin, A. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3089 · Cited by 1,319 · see citing works

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

Lee, Y. S., Nakahara, K., Pham, J. W., Kim, K., He, Z., Sontheimer, E. J., & Carthew, R. W. (2004) · Cell · doi:10.1016/s0092-8674(04)00261-2 · Cited by 1,287 · see citing works

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

Tabara, H., Sarkissian, M., Kelly, W. G., Fleenor, J., Grishok, A., Timmons, L., Fire, A. Z., & Mello, C. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81644-x · Cited by 1,283 · see citing works

Human RISC Couples MicroRNA Biogenesis and Posttranscriptional Gene Silencing

Gregory, R. I., Chendrimada, T. P., Cooch, N., & Shiekhattar, R. (2005) · Cell · doi:10.1016/j.cell.2005.10.022 · Cited by 1,268 · see citing works

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R., & Hannon, G. J. (2001) · Science · doi:10.1126/science.1064023 · Cited by 1,261 · see citing works

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencingPreprint

Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., & Rajewsky, K. (2005) · Genes & Development · doi:10.1101/gad.1248505 · Cited by 1,256 · see citing works

Genetic variation in microRNA networks: the implications for cancer research

Ryan, B. M., Robles, A. I., & Harris, C. C. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2867 · Cited by 1,253 · see citing works

SMAD proteins control DROSHA-mediated microRNA maturation

Davis‐Dusenbery, B. N., Hilyard, A. C., Lagna, G., & Hata, A. (2008) · Nature · doi:10.1038/nature07086 · Cited by 1,243 · see citing works

Diversifying microRNA sequence and function

Ameres, S. L., & Zamore, P. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3611 · Cited by 1,175 · see citing works

Identification of microRNAs of the herpesvirus family

Pfeffer, S., Sewer, A., Lagos‐Quintana, M., Sheridan, R., Sander, C., Grässer, F. A., van Dyk, L. F., Ho, C. K., Shuman, S., Chien, M., et al. (2005) · Nature Methods · doi:10.1038/nmeth746 · Cited by 1,153 · see citing works

Modulation of microRNA processing by p53

Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009) · Nature · doi:10.1038/nature08199 · Cited by 1,125 · see citing works

The microcosmos of cancer

Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084 · see citing works

Single Processing Center Models for Human Dicer and Bacterial RNase III

Zhang, H., Kolb, F. A., Jaśkiewicz, Ł., Westhof, É., & Filipowicz, W. (2004) · Cell · doi:10.1016/j.cell.2004.06.017 · Cited by 1,043 · see citing works

The Mirtron Pathway Generates microRNA-Class Regulatory RNAs in Drosophila

Okamura, K., Hagen, J. W., Duan, H., Tyler, D. M., & Lai, E. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.028 · Cited by 1,028 · see citing works

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

Wang, Y., Medvid, R., Melton, C. A., Jaenisch, R., & Blelloch, R. H. (2007) · Nature Genetics · doi:10.1038/ng1969 · Cited by 1,026 · see citing works

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis

Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,026 · see citing works

ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway

Nykänen, A., Haley, B., & Zamore, P. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00547-5 · Cited by 1,017 · see citing works

Argonaute proteins: functional insights and emerging roles

Meister, G. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3462 · Cited by 1,008 · see citing works

Human embryonic stem cells express a unique set of microRNAs

Suh, M. R., Lee, Y., Kim, J. Y., Kim, S.-K., Moon, S., Lee, J. Y., Cha, K., Chung, H., Yoon, H. S., Moon, S. Y., et al. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.019 · Cited by 974 · see citing works

Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., & Zamore, P. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.044 · Cited by 969 · see citing works

Structural Basis for Double-Stranded RNA Processing by Dicer

MacRae, I. J., Zhou, K., Li, F., Repic, A., Brooks, A. N., Cande, W. Z., Adams, P. D., & Doudna, J. A. (2006) · Science · doi:10.1126/science.1121638 · Cited by 963 · see citing works

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

Heo, I., Joo, C., Cho, J., Ha, M., Han, J., & Kim, V. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.014 · Cited by 947 · see citing works

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.

Landthaler, M., Yalçin, A., & Tuschl, T. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.001 · Cited by 935 · see citing works

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAsPreprint

Babiarz, J., Ruby, J. G., Wang, Y., Bartel, D. P., & Blelloch, R. H. (2008) · Genes & Development · doi:10.1101/gad.1705308 · Cited by 909 · see citing works

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., & Dreyfuss, G. (2002) · Genes &amp; Development · doi:10.1101/gad.974702 · Cited by 886 · see citing works

Processing of intronic microRNAs

Kim, Y. K., & Kim, V. N. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601512 · Cited by 869 · see citing works

A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans

Knight, S. W., & Bass, B. (2001) · Science · doi:10.1126/science.1062039 · Cited by 844 · see citing works

Common SNP in <i>pre-miR-146a</i> decreases mature miR expression and predisposes to papillary thyroid carcinoma

Jazdzewski, K., Murray, E. L., Franssila, K., Jarzab, B., Schoenberg, D. R., & de la Chapelle, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802682105 · Cited by 842 · see citing works

A Human snoRNA with MicroRNA-Like Functions

Ender, C., Krek, A., Friedländer, M. R., Beitzinger, M., Weinmann, L., Chen, W., Pfeffer, S., Rajewsky, N., & Meister, G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.017 · Cited by 837 · see citing works

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysPreprint

岡村, 勝., Ishizuka, A., Siomi, H., & Siomi, M. C. (2004) · Genes & Development · doi:10.1101/gad.1210204 · Cited by 833 · see citing works

Mammalian Mirtron Genes

Berezikov, E., Chung, W., Willis, J., Cuppen, E. P. J. G., & Lai, E. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.028 · Cited by 795 · see citing works

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 788 · see citing works

Modulation of microRNA processing and expression through RNA editing by ADAR deaminases

Yang, W., Chendrimada, T. P., Wang, Q., Higuchi, M., Seeburg, P. H., Shiekhattar, R., & Nishikura, K. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1041 · Cited by 787 · see citing works

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

Rand, T., Petersen, S., Du, F., & Wang, X. (2005) · Cell · doi:10.1016/j.cell.2005.10.020 · Cited by 784 · see citing works

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

Thomson, J. M., Newman, M., Parker, J. S., Morin-Kensicki, E. M., Wright, T., & Hammond, S. M. (2006) · Genes &amp; Development · doi:10.1101/gad.1444406 · Cited by 755 · see citing works

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

Heo, I., Joo, C., Kim, Y.-K., Ha, M., Yoon, M.-J., Cho, J., Yeom, K.-H., Han, J., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.08.002 · Cited by 748 · see citing works

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes &amp; Development · doi:10.1101/gad.1884710 · Cited by 732 · see citing works

Evolution and Functional Diversification of MIRNA Genes

Cuperus, J. T., Fahlgren, N., & Carrington, J. C. (2011) · The Plant Cell · doi:10.1105/tpc.110.082784 · Cited by 722 · see citing works

Evolution of microRNA diversity and regulation in animals

Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712 · see citing works

The role of PACT in the RNA silencing pathway

Lee, Y., Hur, I., Park, S. Y., Kim, Y. K., Suh, M. R., & Kim, V. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600942 · Cited by 698 · see citing works

The Crystal Structure of Human Argonaute2

Schirle, N. T., & MacRae, I. J. (2012) · Science · doi:10.1126/science.1221551 · Cited by 697 · see citing works

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

Newman, M. A., Thomson, J. M., & Hammond, S. M. (2008) · RNA · doi:10.1261/rna.1155108 · Cited by 691 · see citing works

Dual Role for Argonautes in MicroRNA Processing and Posttranscriptional Regulation of MicroRNA Expression

Diederichs, S., & Haber, D. A. (2007) · Cell · doi:10.1016/j.cell.2007.10.032 · Cited by 687 · see citing works

Characterization of Dicer-deficient murine embryonic stem cells

Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S., & Hannon, G. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505479102 · Cited by 684 · see citing works

Chromatin structure analyses identify miRNA promotersPreprint

Ozsolak, F., Poling, L. L., Wang, Z., Liu, H., Liu, X., Roeder, R. G., Zhang, X., Song, J. S., & Fisher, D. E. (2008) · Genes & Development · doi:10.1101/gad.1706508 · Cited by 670 · see citing works

TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing

Haase, A. D. D., Jaśkiewicz, Ł., Zhang, H., Lainé, S., Sack, R., Gatignol, A., & Filipowicz, W. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400509 · Cited by 657 · see citing works

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

Trabucchi, M., Briata, P., García‐Mayoral, M. F., Haase, A. D. D., Filipowicz, W., Ramos, A., Gherzi, R., & Rosenfeld, M. G. (2009) · Nature · doi:10.1038/nature08025 · Cited by 652 · see citing works

Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

Ma, J., Yuan, Y. A., Meister, G., Pei, Y., Tuschl, T., & Patel, D. J. (2005) · Nature · doi:10.1038/nature03514 · Cited by 649 · see citing works

The dsRNA protein kinase PKR: Virus and cell control

García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644 · see citing works

IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

Upton, J.-P., Wang, L., Han, D., Wang, E. S., Huskey, N. E., Lim, L., Truitt, M., McManus, M. T., Ruggero, D., Goga, A., et al. (2012) · Science · doi:10.1126/science.1226191 · Cited by 640 · see citing works

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

Zhang, H., Kolb, F. A., Brondani, V., Billy, É., & Filipowicz, W. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf582 · Cited by 631 · see citing works

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

Frank, F., Sonenberg, N., & Nagar, B. (2010) · Nature · doi:10.1038/nature09039 · Cited by 625 · see citing works

The Structure of Human Argonaute-2 in Complex with miR-20a

Elkayam, E., Kuhn, C., Tocilj, A., Haase, A. D. D., Greene, E. M., Hannon, G. J., & Joshua‐Tor, L. (2012) · Cell · doi:10.1016/j.cell.2012.05.017 · Cited by 615 · see citing works

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601 · see citing works

Target RNA–Directed Trimming and Tailing of Small Silencing RNAs

Ameres, S. L., Horwich, M. D., Hung, J.-H., Xu, J., Ghildiyal, M., Weng, Z., & Zamore, P. D. (2010) · Science · doi:10.1126/science.1187058 · Cited by 597 · see citing works

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