Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Drawnel, Faye M., Boccardo, Stefano, Prummer, Michael, Delobel, Frédéric, Graff, Alexandra, Weber, Michael, Gérard, Régine, Badi, Laura +18 more·2014·Cell Reports
DOI 10.1016/j.celrep.2014.09.055

Cited by (256)

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  7. Multiomics-based assessment of 2D and 3D human iPSC-cardiomyocyte models of insulin resistance demonstrate metabolic and contractile dysfunction that recapitulates diabetic cardiomyopathy
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  11. Transcriptome analysis of serum biomarker, shared gene signature and pharmacological targets between diabetic cardiomyopathy and nephropathy
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  12. Modelling diabetes-associated metabolic stress in human multicellular cardiac microtissues
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  13. A Role for in Vitro Disease Models in the Landscape of Preclinical Cardiotoxicity and Safety Testing
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  17. iPS Cells and Cardiomyopathies
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  18. Induced pluripotent stem cells from patients with hypoplastic left heart syndrome (HLHS) as a model to study functional contribution of endothelial-mesenchymal transition (EndMT) in HLHS
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  19. Generation and Application of Human Pluripotent Stem Cell-Derived Cardiomyocytes
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  22. Dissociation of disease phenotype and allele silencing in hypertrophic cardiomyopathy
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  23. Metabolic phenotyping of the pressure-overloaded heart
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  24. Effects of Ceramide Accumulation in Cardiomyocytes Derived from human-induced Pluripotent Stem Cells on Mitochondrial Function and Mitophagy
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  25. Applications of iPSCs in Cancer Research
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  26. Peer Review #2 of "Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? (v0.1)"
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  28. Peer Review #1 of "Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? (v0.1)"
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  29. Glucose Counteracts Isoprenaline Effects on Ion Channel Functions in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
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  30. 2 Human-Induced Pluripotent Stem Cells: Banking and Characterization
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  31. Recent Advances in In Vitro Generation of Mature Cardiomyocytes
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  32. Induced pluripotent stem cells for cardiovascular therapeutics: Progress and perspectives
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  33. Additional file 6 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
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  34. Additional file 2 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
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  35. Additional file 7 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
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  36. Additional file 5 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
    Xiangfei Sun, Ying Jiang, Qingbao Li, Qi Tan, Mingliang Dong, Bi’e Cai, Di Zhang, Zhao, Qi · 2023 · Figshare
  37. Additional file 1 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
    Xiangfei Sun, Ying Jiang, Qingbao Li, Qi Tan, Mingliang Dong, Bi’e Cai, Di Zhang, Zhao, Qi · 2023 · Figshare
  38. Additional file 3 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
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  39. Additional file 4 of Quantitative proteomics analysis revealed the potential role of lncRNA Ftx in cardiomyocytes
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  40. Promotion of maturation in CDM3-induced embryonic stem cell-derived cardiomyocytes by palmitic acid
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  41. Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes
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  42. Label-free method to monitor metabolism during long-term culture of human pluripotent stem cell derived cardiomyocytes
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  44. Additional file 1 of Modeling of Fabry disease nephropathy using patient derived human induced pluripotent stem cells and kidney organoid system
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  45. Maturité des cardiomyocytes humains et dystrophinopathies : modélisation de la cardiomyopathie dilatée associée à la Dystrophie de Duchenne à partir d'hiPSC
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  46. Serum-assisted metabolic priming enables robust structural maturation of hiPSC-cardiomyocytes in 2D and 3D systems
    Xuan‐Hung Nguyen, Manh Khanh Dinh, Minh-Anh Thi Dang, Tuan-Anh Pham, Nhung Thi Hong Nguyen, Linh Dieu Do, Nhung Thi My Hoang · 2026 · The International Journal of Biochemistry & Cell Biology
  47. Biomaterials as blueprints: Architecting functional vascularized cardiac organoids
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  48. What Is the Current State of Stem Cell Therapy in Diabetes?
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  49. Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction
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  50. Multiple applications of cardiac organoids
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  51. Cardiac SGLT2 Expression and Cell-Type-Specific Responses to Empagliflozin in iPSC-Derived Models of Diabetic Cardiomyopathy
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  52. Compartment-specific cAMP dysfunction in diabetic cardiomyopathy in hiPSC-derived cardiomyocytes: therapeutic potential of fibroblast growth factor 1
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  54. iPSC-derived cardiomyocytes for personalized medicine- promises and challenges
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  55. BindingDB Entry 50017258: Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes.
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  56. BindingDB Entry 50022566: GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes.
    BindingDB · 2025 · UC San Diego