Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
Open accessAbstract
Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using human-induced-pluripotent-stem-cell-derived cardiomyocytes. First, we mimic diabetic clinical chemistry to induce a phenotypic surrogate of diabetic cardiomyopathy, observing structural and functional disarray. Next, we consider genetic effects by deriving cardiomyocytes from two diabetic patients with variable disease progression. The cardiomyopathic phenotype is recapitulated in the patient-specific cells basally, with a severity dependent on their original clinical status. These models are incorporated into successive levels of a screening platform, identifying drugs that preserve cardiomyocyte phenotype in vitro during diabetic stress. In this work, we present a patient-specific induced pluripotent stem cell (iPSC) model of a complex metabolic condition, showing the power of this technique for discovery and testing of therapeutic strategies for a disease with ever-increasing clinical significance.
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AI models can simulate the biological effects of potential drug compounds on patients with diabetes, predicting efficacy and side effects before clinical trials.
“AI models can simulate the biological effects of potential drug compounds on patients with diabetes, predicting efficacy and side effects before clinical trials (60).”
From Generative artificial intelligence in predictive analysis of diabetes and its complications: a narrative review (2025) · cites this paper as [60]
The High-Content Phenotypic Screening section reports testing compounds on diabetic cardiomyopathy cell models and measuring improvements in disease-related parameters. The Discussion describes these as patient-specific, iPSC-derived cardiomyocyte models, not AI models, and says testing the assay’s predictive power in vivo remains a future goal. The paper does not establish predictions of efficacy or side effects in patients before clinical trials. (LLM, conf=0.88)
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Cites
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,308 · see citing works
Calcium cycling and signaling in cardiac myocytes.
Bers, D. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100455 · Cited by 1,386 · see citing works
Impact of Diabetes on Cardiac Structure and Function
Devereux, R. B., Roman, M. J., Paranicas, M., O’Grady, M. J., Lee, E. T., Welty, T. K., Fabsitz, R. R., Robbins, D. C., Rhoades, E. R., & Howard, B. V. (2000) · Circulation · doi:10.1161/01.cir.101.19.2271 · Cited by 943 · see citing works
Engineering Adolescence: Maturation of Human Pluripotent Stem Cell–Derived Cardiomyocytes
Yang, X., Pabon, L., & Murry, C. E. (2014) · Circulation Research · doi:10.1161/circresaha.114.300558 · Cited by 939 · see citing works
Ma, J., Guo, L., Fiene, S., Anson, B. D., Thomson, J. A., Kamp, T. J., Kolaja, K. L., Swanson, B. J., & January, C. T. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00694.2011 · Cited by 773 · see citing works
Self-citationPatient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696 · see citing works
Lan, F., Lee, A. S., Liang, P., Sanchez-Freire, V., Nguyen, P. K., Wang, L., Han, L., Yen, M., Wang, Y., Sun, N., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.10.010 · Cited by 667 · see citing works
Lopaschuk, G. D., & Jaswal, J. S. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181e74a14 · Cited by 636 · see citing works
Kim, K., Zhao, R., Doi, A., Ng, K., Unternaehrer, J., Cahan, P., Huo, H., Loh, Y., Aryee, M. J., Lensch, M. W., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.2052 · Cited by 613 · see citing works
ER stress in cardiovascular disease
Minamino, T., & Kitakaze, M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.10.026 · Cited by 456 · see citing works
Return to the fetal gene program
Taegtmeyer, H., Sen, S., & Vela, D. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05100.x · Cited by 415 · see citing works
Diabetic nephropathy—emerging epigenetic mechanisms
Kato, M. V., & Natarajan, R. D. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.116 · Cited by 316 · see citing works
Oxidative Stress and Sarcomeric Proteins
Steinberg, S. F. (2013) · Circulation Research · doi:10.1161/circresaha.111.300496 · Cited by 195 · see citing works
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes
Mandavia, C. H., Aroor, A. R., DeMarco, V. G., & Sowers, J. R. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.10.028 · Cited by 190 · see citing works
Elevated plasma endothelin-1 levels in diabetes mellitus
Schneider, J. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)03060-1 · Cited by 165 · see citing works
Metabolism, hypoxia and the diabetic heart
Heather, L. C., & Clarke, K. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.01.007 · Cited by 131 · see citing works
Abassi, Y. A., Xi, B., Li, N., Ouyang, W., Seiler, A., Watzele, M., Kettenhofen, R. F., Bohlen, H., Ehlich, A., Kolossov, E., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01623.x · Cited by 125 · see citing works
Reynolds, R. M., Labad, J., Strachan, M. W. J., Braun, A., Fowkes, F. G. R., Lee, A. J., Frier, B. M., Seckl, J. R., Walker, B. R., Price, J. F., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2112 · Cited by 113 · see citing works
Glycemic memory associated epigenetic changes
Siebel, A. L., Fernández, A. Z., & El‐Osta, A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.005 · Cited by 103 · see citing works
Carlson, C. B., Koonce, C. H., Aoyama, N., Einhorn, S., Fiene, S., Thompson, A., Swanson, B., Anson, B. D., & Kattman, S. J. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113500812 · Cited by 100 · see citing works
Self-citationDrawnel, F., Archer, C. R., & Roderick, H. L. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02195.x · Cited by 94 · see citing works
Self-citationPluripotent stem cell models of human heart disease.Preprint
Moretti, A., Laugwitz, K., Dorn, T., Sinnecker, D., & Mummery, C. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014027 · Cited by 94 · see citing works
Alteration of Energy Substrates and ROS Production in Diabetic Cardiomyopathy
Lorenzo, Ó., Ramírez, E., Picatoste, B., Egido, J., & Tuñón, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/461967 · Cited by 70 · see citing works
Genetics of diabetes complications
Bowden, D. W. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0080-8 · Cited by 33 · see citing works
Hypothesis Testing in High-Throughput Screening for Drug Discovery
Prummer, M. (2012) · SLAS DISCOVERY · doi:10.1177/1087057111431278 · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
Jia, G., DeMarco, V. G., & Sowers, J. R. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.216 · Cited by 954 · see citing works
Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478 · see citing works
Translation of Human iPSCs: From Clinical Trial in a Dish to Precision Medicine
Sayed, N., Liu, C., & Wu, J. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.083 · Cited by 263 · see citing works
Current status of pluripotent stem cells: moving the first therapies to the clinic
Kimbrel, E. A., & Lanza, R. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4738 · Cited by 263 · see citing works
Correia, C., Koshkin, A., Duarte, P., Hu, D., Teixeira, A. P., Domian, I. J., Serra, M., & Alves, P. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-08713-4 · Cited by 237 · see citing works
Paik, D. T., Chandy, M., & Wu, J. C. (2019) · Pharmacological Reviews · doi:10.1124/pr.116.013003 · Cited by 216 · see citing works
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells
Birket, M. J., Ribeiro, M. C., Verkerk, A. O., Ward, D., Leitoguinho, A. R., Hartogh, S. C. D., Orlova, V. V., Devalla, H. D., Schwach, V., Bellin, M., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3271 · Cited by 207 · see citing works
Kitani, T., Ong, S.-G., Lam, C. K., Rhee, J.-W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037357 · Cited by 200 · see citing works
Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis
Nakano, H., Minami, I., Braas, D., Pappoe, H., Wu, X., Sagadevan, A., Vergnes, L., Fu, K., Morselli, M., Dunham, C., et al. (2017) · eLife · doi:10.7554/elife.29330 · Cited by 195 · see citing works
Birket, M. J., Ribeiro, M. C., Kosmidis, G., Ward, D., Leitoguinho, A. R., van de Pol, V., Dambrot, C., Devalla, H. D., Davis, R. P., Mastroberardino, P. G., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.025 · Cited by 192 · see citing works
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
Chen, I. Y., Matsa, E., & Wu, J. C. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.36 · Cited by 191 · see citing works
Contractile work contributes to maturation of energy metabolism in hiPSC-derived cardiomyocytes
Ulmer, B. M., Stoehr, A., Schulze, M. L., Patel, S., Gucek, M., Mannhardt, I., Funcke, S., Murphy, E., Eschenhagen, T., & Hansen, A. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.01.039 · Cited by 183 · see citing works
Horikoshi, Y., Yan, Y., Terashvili, M., Wells, C. W., Horikoshi, H., Fujita, S., Bosnjak, Z. J., & Bai, X. (2019) · Cells · doi:10.3390/cells8091095 · Cited by 167 · see citing works
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
Ramaccini, D., Montoya-Uribe, V., Aan, F. J., Modesti, L., Potes, Y., Wieckowski, M. R., Krga, I., Glibetić, M., Pinton, P., Giorgi, C., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.624216 · Cited by 136 · see citing works
Sabapathy, V., & Kumar, S. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12839 · Cited by 126 · see citing works
Sürün, D., Schneider, A., Mircetic, J., Neumann, K., Lansing, F., Paszkowski‐Rogacz, M., Hänchen, V., Lee‐Kirsch, M. A., & Buchholz, F. (2020) · Genes · doi:10.3390/genes11050511 · Cited by 121 · see citing works
Quraishi, I. H., Stern, S., Mangan, K. P., Zhang, Y., Ali, S. R., Mercier, M. R., Marchetto, M. C., McLachlan, M. J., Jones, E. M., Gage, F. H., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1628-18.2019 · Cited by 103 · see citing works
Wu, S., Xu, R., Duan, B., & Jiang, P. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00721c · Cited by 111 · see citing works
Cardiovascular Precision Medicine in the Genomics Era
Dainis, A., & Ashley, E. A. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.01.003 · Cited by 117 · see citing works
Biology of the cardiac myocyte in heart disease
Peter, A. K., Bjerke, M. A., & Leinwand, L. A. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-01-0038 · Cited by 109 · see citing works
Magdy, T., Schuldt, A. J. T., Wu, J. C., Bernstein, D., & Burridge, P. W. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-053110 · Cited by 112 · see citing works
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes
Machiraju, P., & Greenway, S. C. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i1.33 · Cited by 108 · see citing works
Matsa, E., Ahrens, J. H., & Wu, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00036.2015 · Cited by 105 · see citing works
Sirenko, O., Grimm, F. A., Ryan, K., Iwata, Y., Chiu, W. A., Parham, F., Wignall, J., Anson, B. D., Cromwell, E. F., Behl, M., et al. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.02.020 · Cited by 102 · see citing works
Ergir, E., Oliver-De La Cruz, J., Fernandes, S., Cassani, M., Niro, F., Pereira-Sousa, D., Vrbský, J., Vinarský, V., Perestrelo, A. R., Debellis, D., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22225-w · Cited by 99 · see citing works
Magdy, T., Jouni, M., Kuo, H., Weddle, C. J., Lyra‐Leite, D. M., Fonoudi, H., Romero‐Tejeda, M., Gharib, M., Javed, H., Fajardo, G., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.055801 · Cited by 96 · see citing works
Repurposing drugs to treat cardiovascular disease in the era of precision medicine
Abdelsayed, M., Kort, E. J., Jovinge, S., & Mercola, M. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00717-6 · Cited by 93 · see citing works
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies
Brandão, K. O., Tabel, V. A., Atsma, D. E., Mummery, C. L., & Davis, R. P. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030320 · Cited by 91 · see citing works
Generation of Endothelial Cells From Human Pluripotent Stem Cells
Williams, I. M., & Wu, J. C. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312265 · Cited by 93 · see citing works
Modeling Cardiovascular Diseases with hiPSC-Derived Cardiomyocytes in 2D and 3D Cultures
Sacchetto, C., Vitiello, L., de Windt, L. J., Rampazzo, A., & Calore, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093404 · Cited by 91 · see citing works
Oikonomopoulos, A., Kitani, T., & Wu, J. C. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.02.026 · Cited by 89 · see citing works
Ng, K., Lau, Y., Dhandhania, V., Cai, Z., Lee, Y.-K., Lai, W., Tse, H., & Siu, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-33293-2 · Cited by 87 · see citing works
Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair
Gartz, M., & Strande, J. L. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007954 · Cited by 85 · see citing works
Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?
Magdy, T., Burmeister, B. T., & Burridge, P. W. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.09.009 · Cited by 84 · see citing works
Metabolic remodeling in early development and cardiomyocyte maturation
Kreipke, R. E., Wang, Y., Miklas, J. W., Mathieu, J., & Ruohola‐Baker, H. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.004 · Cited by 82 · see citing works
iPSC technology‐based regenerative therapy for diabetes
Kondo, Y., Toyoda, T., Inagaki, N., & Osafune, K. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12702 · Cited by 81 · see citing works
Bekhite, M. M., Delgado, A. G., Hübner, S., Haxhikadrija, P., Kretzschmar, T., Müller, T., Wu, J. M. F., Bekfani, T., Franz, M., Wartenberg, M., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.016 · Cited by 83 · see citing works
Towards a better understanding of diabetes mellitus using organoid models
Beydag-Tasöz, B. S., Yennek, S., & Grapin‐Botton, A. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00797-x · Cited by 83 · see citing works
Stem-cell based organ-on-a-chip models for diabetes research
Rogal, J., Zbinden, A., Schenke‐Layland, K., & Loskill, P. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.010 · Cited by 83 · see citing works
Cardiovascular Toxicity Induced by Kinase Inhibitors: Mechanisms and Preclinical Approaches
Lamore, S. D., Kohnken, R. A., Peters, M. F., & Kolaja, K. L. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00387 · Cited by 79 · see citing works
Self-citationGuidelines on models of diabetic heart disease
Heather, L. C., Hafstad, A. D., Halade, G. V., Harmancey, R., Mellor, K. M., Mishra, P. K., Mulvihill, E. E., Nabben, M., Nakamura, M., Rider, O. J., et al. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00058.2022 · Cited by 79 · see citing works
Clinical potentials of human pluripotent stem cells
Mora, C., Serzanti, M., Consiglio, A., Memo, M., & Dell’Era, P. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9384-y · Cited by 77 · see citing works
In Vitro Models of Ischemia-Reperfusion Injury
Chen, T. F., & Vunjak‐Novakovic, G. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0056-0 · Cited by 79 · see citing works
Human iPSC modeling of heart disease for drug development
Hnatiuk, A. P., Briganti, F., Staudt, D., & Mercola, M. A. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.02.016 · Cited by 79 · see citing works
Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery
Tani, H., & Tohyama, S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.855763 · Cited by 70 · see citing works
Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic Cardiomyopathies
Brodehl, A., Ebbinghaus, H., Deutsch, M., Gummert, J., Gärtner, A., Ratnavadivel, S., & Milting, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184381 · Cited by 58 · see citing works
From engineered heart tissue to cardiac organoid
Cho, J., Lee, H., Rah, W., Chang, H., & Yoon, Y. (2022) · Theranostics · doi:10.7150/thno.67661 · Cited by 66 · see citing works
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
Phang, R. J., Ritchie, R. H., Hausenloy, D. J., Lees, J. G., & Lim, S. Y. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac049 · Cited by 65 · see citing works
van Mil, A., Balk, G. M., Neef, K., Buikema, J. W., Asselbergs, F. W., Wu, S. M., Doevendans, P. A., & Sluijter, J. P. G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy208 · Cited by 65 · see citing works
The development of high-content screening (HCS) technology and its importance to drug discovery
Fraietta, I., & Gasparri, F. (2016) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2016.1165203 · Cited by 65 · see citing works
Neves, L. S., Rodrigues, M. T., Reis, R. L., & Gomes, M. E. (2016) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2016.1140004 · Cited by 63 · see citing works
Induced Pluripotent Stem Cells: Next Generation Cells for Tissue Regeneration
Ibrahim, A. Y., Mehdi, M. Q., Abbas, A. O., Alashkar, A. H., & Haider, K. H. (2016) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2016.94017 · Cited by 61 · see citing works
Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
Giacomelli, E., Mummery, C. L., & Bellin, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2546-5 · Cited by 60 · see citing works
Modeling Heart Diseases on a Chip: Advantages and Future Opportunities
Mourad, O., Yee, R., Li, M., & Nunes, S. S. (2023) · Circulation Research · doi:10.1161/circresaha.122.321670 · Cited by 60 · see citing works
Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism
Ulmer, B. M., & Thomas Eschenhagen, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.04.001 · Cited by 54 · see citing works
Silencing of MYH7 ameliorates disease phenotypes in human iPSC-cardiomyocytes
Dainis, A., Zaleta-Rivera, K., Ribeiro, A. J. S., Chang, A. C. H., Shang, C., Lan, F., Burridge, P. W., Liu, W. R., Wu, J. C., Chang, A. C. Y., et al. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00021.2020 · Cited by 52 · see citing works
Pluripotent Stem Cell Platforms for Drug Discovery
Chen, K. G., Mallon, B. S., Park, K., Robey, P. G., McKay, R. D. G., Gottesman, M. M., & Zheng, W. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.06.009 · Cited by 51 · see citing works
Cardiovascular Disease Modeling Using Patient-Specific Induced Pluripotent Stem Cells
Tanaka, A., Yuasa, S., Node, K., & Fukuda, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818894 · Cited by 52 · see citing works
McKeithan, W. L., Feyen, D. A. M., Bruyneel, A. A. N., Okolotowicz, K. J., Ryan, D. A., Sampson, K. J., Potet, F., Savchenko, A., Gómez-Galeno, J., Vu, M., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.08.003 · Cited by 50 · see citing works
Podkalicka, P., Stępniewski, J., Mucha, O., Kachamakova‐Trojanowska, N., Dulak, J., & Łoboda, A. (2020) · Biomolecules · doi:10.3390/biom10121614 · Cited by 49 · see citing works
Pluripotent stem cell derived cardiovascular progenitors – A developmental perspective
Birket, M. J., & Mummery, C. L. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.01.012 · Cited by 47 · see citing works
Hidalgo, A., Glass, N. R., Ovchinnikov, D. A., Yang, S., Zhang, X., Mazzone, S. B., Chen, C., Wolvetang, E. J., & Cooper-White, J. J. (2018) · APL Bioengineering · doi:10.1063/1.5000746 · Cited by 46 · see citing works
Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate
Persad, K. L., & Lopaschuk, G. D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886393 · Cited by 47 · see citing works
Dou, W., Zhao, Q., Malhi, M., Liu, X., Zhang, Z., Wang, L., Massé, S., Nanthakumar, K., Hamilton, R. M., Maynes, J. T., et al. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112468 · Cited by 43 · see citing works
Stem Cells for Modeling and Therapy of Parkinson's Disease
Zhang, Q., Chen, W.-L., Tan, S. H. D., & Lin, T. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.116 · Cited by 42 · see citing works
Malandraki-Miller, S., Lopez, C. A., Al-Siddiqi, H., & Carr, C. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00119 · Cited by 43 · see citing works
Cavero, I., Guillon, J., Ballet, V., Clements, M., Gerbeau, J.-F., & Holzgrefe, H. H. (2016) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2016.05.012 · Cited by 41 · see citing works
Induced Pluripotent Stem Cells in Disease Modeling and Gene Identification
Kumar, S., Blangero, J., & Curran, J. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7471-9_2 · Cited by 41 · see citing works
Mechanotransduction and Metabolism in Cardiomyocyte Microdomains
Pasqualini, F. S., Nesmith, A. P., Horton, R. E., Sheehy, S. P., & Parker, K. K. (2016) · BioMed Research International · doi:10.1155/2016/4081638 · Cited by 39 · see citing works
Clinical trials in-a-dish for cardiovascular medicine
Wu, X., Swanson, K., Yıldırım, Z., Liu, W., Liao, R., & Wu, J. C. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae519 · Cited by 40 · see citing works
Liang, Y., Zhang, X., Zhou, Q., Tan, B., Xu, H., Yi, Q., Liang, Y., Xie, M., Zhang, Y., Tian, J., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.644667 · Cited by 38 · see citing works
van den Brink, L., Grandela, C., Mummery, C. L., & Davis, R. P. (2019) · Stem Cells · doi:10.1002/stem.3110 · Cited by 36 · see citing works
Modeling different types of diabetes using human pluripotent stem cells
Abdelalim, E. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03710-9 · Cited by 38 · see citing works
Lopez, C. A., Al-Siddiqi, H., Purnama, U., Iftekhar, S., Bruyneel, A. A. N., Kerr, M. J., Nazir, R., Fialho, M. D. L. S., Malandraki-Miller, S., Alonaizan, R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87186-y · Cited by 36 · see citing works
Yu, Y., Sun, S., Wang, S., Zhang, Q., Li, M., Lan, F., Li, S., & Liu, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020186 · Cited by 36 · see citing works
Granéli, C., Hicks, R., Brolén, G., Synnergren, J., & Sartipy, P. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9858-1 · Cited by 36 · see citing works
Toyohara, T., Roudnicky, F., Florido, M. H. C., Nakano, T., Yu, H., Katsuki, S., Lee, M., Meissner, T. B., Friesen, M., Davidow, L. S., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.04.018 · Cited by 35 · see citing works
Patient-Specific Induced Pluripotent Stem Cells for Disease Modeling and Phenotypic Drug Discovery
Tang, S., Xie, M., Cao, N., & Ding, S. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00789 · Cited by 35 · see citing works
Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications
Tashkandi, A. J. A., Gorman, A., Mathers, E. M., Carney, G., Yacoub, A., Setyaningsih, W. A. W., Kuburas, R., & Margariti, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073016 · Cited by 35 · see citing works
Rosales, W., & Lizcano, F. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00014 · Cited by 34 · see citing works
Regulation of the Microenvironment for Cardiac Tissue Engineering
Wanjare, M., & Huang, N. F. (2017) · Regenerative Medicine · doi:10.2217/rme-2016-0132 · Cited by 34 · see citing works
Inherited heart disease – what can we expect from the second decade of human i PS cell research?
Bellin, M., & Mummery, C. L. (2016) · FEBS Letters · doi:10.1002/1873-3468.12285 · Cited by 33 · see citing works
Drawnel, F., Zhang, J. D., Küng, E., Aoyama, N., Benmansour, F., Rosario, A. A. D., Zoffmann, S., Delobel, F., Prummer, M., Weibel, F., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.03.016 · Cited by 33 · see citing works
Self-citationGenerating Kidney from Stem Cells
Little, M. H., Hale, L. J., Howden, S. E., & Kumar, S. V. R. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114331 · Cited by 33 · see citing works
Fabre, K. M., Delsing, L., Hicks, R., Colclough, N., Crowther, D. C., & Ewart, L. C. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.09.009 · Cited by 32 · see citing works
Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets
Kim, M., Cho, S., Hwang, D. G., Shim, I., Kim, S. C., Jang, J., & Jang, J.-A. (2025) · Nature Communications · doi:10.1038/s41467-025-56665-5 · Cited by 31 · see citing works
Ramachandra, C. J. A., Chua, J., Cong, S., Ja, K. P. M. M., SHIM, W. S. N., Wu, J. C., & Hausenloy, D. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa125 · Cited by 29 · see citing works
Applications of iPSCs in Cancer Research
Kim, J. (2015) · Biomarker Insights · doi:10.4137/bmi.s20065 · Cited by 28 · see citing works
GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes
Bowman, P. R. T., Smith, G. L., & Gould, G. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217885 · Cited by 28 · see citing works
Sante, M. D., Antonucci, S., Pontarollo, L., Cappellaro, I., Segat, F., Deshwal, S., Greotti, E., Grilo, L. F., Menabò, R., Lisa, F. D., et al. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-00977-4 · Cited by 27 · see citing works
Teo, A. K. K., Gupta, M. K., Doria, A., & Kulkarni, R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.006 · Cited by 26 · see citing works
Kempf, H., & Zweigerdt, R. (2017) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2017_30 · Cited by 26 · see citing works
Zhu, K., Bao, X., Wang, Y., Lu, T., & Zhang, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113970 · Cited by 26 · see citing works
Chien, Y., Chien, C., Chiang, H.-C., Huang, W.-L., Chou, S., Chang, W., Chang, Y.-L., Leu, H., Chen, K.-H., Wang, K.-L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13552 · Cited by 26 · see citing works
Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs
Guo, H., Liu, L., Nishiga, M., Cong, L., & Wu, J. C. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.08.009 · Cited by 27 · see citing works
Phenotypic assays for analyses of pluripotent stem cell–derived cardiomyocytes
Pešl, M., Přibyl, J., Caluori, G., Čmiel, V., Aćimović, I., Jelínková, Š., Dvořák, P., Stárek, Z., Skládal, P., & Rotrekl, V. (2016) · Journal of Molecular Recognition · doi:10.1002/jmr.2602 · Cited by 25 · see citing works
No functional TRPA1 in cardiomyocytes
Hoebart, C., Rojas‐Galvan, N. S., Ciotu, C. I., Aykac, I., Reissig, L. F., Weninger, W. J., Kiss, A., Podesser, B. K., Fischer, M. J. M., & Heber, S. (2021) · Acta Physiologica · doi:10.1111/apha.13659 · Cited by 23 · see citing works
Cui, S., Fang, X., Lee, H., Shin, Y., Koh, E.-S., Chung, S., Park, H. S., Lim, S. W., Lee, K. I., Lee, J. Y., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03992-0 · Cited by 24 · see citing works
Park, T. S., Zimmerlin, L., Evans-Moses, R., Thomas, J., Huo, J. S., Kanherkar, R., He, A., Ruzgar, N. M., Grebe, R. R., Bhutto, I. A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14764-5 · Cited by 24 · see citing works
Jiang, X., Lian, X., Wei, K., Zhang, J., Yu, K., Li, H., Ma, H., Cai, Y., & Pang, L. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03961-4 · Cited by 23 · see citing works
Self-citation
- Authors
- Drawnel, F. M., Boccardo, S., Prummer, M., Delobel, F., Graff, A., Weber, M., Gérard, R., Badi, L., Kam-Thong, T., Bu, L., Jiang, X., Hoflack, J.-C., Kiialainen, A., Jeworutzki, E., Aoyama, N., Carlson, C., Burcin, M., Gromo, G., Boehringer, M., Stahlberg, H., Hall, B. J., Magnone, M. C., Kolaja, K., Chien, K. R., Bailly, J., & Iacone, R.
- Affiliations
- F. Hoffmann-La Roche AG (CH)
- University of Basel (CH)
- Massachusetts General Hospital (US)
- Cellular Dynamics International (United States) (US)
- Harvard University (US)
- Corresponding author
- Iacone, Roberto
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 9
- Issue
- 3
- Pages
- 810-820
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2116314385
- Cited by
- 247
- References
- 25
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 14 · 2023: 18 · 2022: 18 · 2021: 28 · 2020: 22 · 2019: 22 · 2018: 27 · 2017: 25 · 2016: 27 · 2015: 17
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- diabetic cardiomyopathy, type 2 diabetes, human induced pluripotent stem cells, iPSC-derived cardiomyocytes, disease modeling, phenotypic screening, patient-specific disease models, cardiomyocyte dysfunction, disease severity
- MeSH terms
- Cell Differentiation, Drug Evaluation, Preclinical, Humans, Hypertrophy, Models, Biological, Phenotype, Sarcomeres, Lipid Peroxidation, Myocytes, Cardiac, Lipid Metabolism, Small Molecule Libraries, Induced Pluripotent Stem Cells, Diabetic Cardiomyopathies
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