The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis
Open accessAbstract
The testis produces sperm throughout the male reproductive lifespan by balancing self-renewal and differentiation of spermatogonial stem cells (SSCs). Part of the SSC niche is thought to lie outside the seminiferous tubules of the testis; however, specific interstitial components of the niche that regulate spermatogonial divisions and differentiation remain undefined. We identified distinct populations of testicular macrophages, one of which lies on the surface of seminiferous tubules, in close apposition to areas of tubules enriched for undifferentiated spermatogonia. These macrophages express spermatogonial proliferation- and differentiation-inducing factors, such as colony-stimulating factor 1 (CSF1) and enzymes involved in retinoic acid (RA) biosynthesis. We show that transient depletion of macrophages leads to a disruption in spermatogonial differentiation. These findings reveal an unexpected role for macrophages in the spermatogonial niche in the testis and raise the possibility that macrophages play previously unappreciated roles in stem/progenitor cell regulation in other tissues.
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Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S. W., & Ruhrberg, C. (2010) · Blood · doi:10.1182/blood-2009-12-257832 · Cited by 1,153
Köhler, C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0474-7 · Cited by 120
Cited by
The adult human testis transcriptional cell atlas
Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0099-2 · Cited by 710
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
The nature and dynamics of spermatogonial stem cells
de Rooij, D. G. (2017) · Development · doi:10.1242/dev.146571 · Cited by 313
The many ways tissue phagocytes respond to dying cells
Blander, J. M. (2017) · Immunological Reviews · doi:10.1111/imr.12537 · Cited by 84
Common principles of macrophage biology in blood–tissue barriers
Hiraga, S., & Masuda, T. (2024) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12812 · Cited by 2
Metadata
- Authors
- DeFalco, T., Potter, S. J., Williams, A. V., Waller, B., Kan, M. J., & Capel, B.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 12
- Issue
- 7
- Pages
- 1107-1119
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W1723001059
- Cited by
- 336
- References
- 5
- FWCI
- 27.19
- Type
- journal article
- Language
- en
- Open access
- gold
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