The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The adult human testis transcriptional cell atlas
Open accessAbstract
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility and faithful genome propagation. Here, we performed single-cell RNA sequencing of ~6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig, myoid, Sertoli, endothelial, macrophage), and observed germline-niche interactions and key human-mouse differences. Spermatogenesis, including meiosis, was reconstructed computationally, revealing sequential coding, non-coding, and repeat-element transcriptional signatures. Interestingly, we identified five discrete transcriptional/developmental spermatogonial states, including a novel early SSC state, termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the origin of State 0, we profiled testicular cells from infants, and identified distinct similarities between adult State 0 and infant SSCs. Overall, our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis, and provide new insights into germ cell developmental transitions and plasticity.
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1 retracted
Human Epididymis Protein-4 (HE-4): A Novel Cross-Class Protease Inhibitor
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RetractedSpatial reconstruction of single-cell gene expression data
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Self-citationSlingshot: cell lineage and pseudotime inference for single-cell transcriptomics
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A single–cell type transcriptomics map of human tissues
Karlsson, M., Zhang, C., Méar, L., Zhong, W., Digre, A., Katona, B., Sjöstedt, E., Butler, L., Odeberg, J., Dusart, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2169 · Cited by 1,768
Self-citationTransfer learning enables predictions in network biology
Theodoris, C. V., Xiao, L., Chopra, A., Chaffin, M. D., Al Sayed, Z. R., Hill, M. C., Mantineo, H., Brydon, E. M., Zeng, Z., Liu, X. S., et al. (2023) · Nature · doi:10.1038/s41586-023-06139-9 · Cited by 1,193
Construction of a human cell landscape at single-cell level
Han, X., Zhou, Z., Fei, L., Sun, H., Wang, R., Chen, Y., Chen, H., Wang, J., Tang, H., Ge, W., et al. (2020) · Nature · doi:10.1038/s41586-020-2157-4 · Cited by 1,087
The protein expression profile of ACE2 in human tissues
Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209610 · Cited by 1,016
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Metadata
- Authors
- Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., Kim, R., Carrell, D. T., Goriely, A., Hotaling, J. M., & Cairns, B. R.
- Venue
- Cell Research
- Published
- 2018-10-12
- Volume
- 28
- Issue
- 12
- Pages
- 1141-1157
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2896156331
- Cited by
- 710
- References
- 45
- FWCI
- 47.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Guo, J., Grow, E. J., Mlcochova, H., Maher, G. J., Lindskog, C., Nie, X., Guo, Y., Takei, Y., Yun, J., Cai, L., Kim, R., Carrell, D. T., Goriely, A., Hotaling, J. M., & Cairns, B. R. (2018). The adult human testis transcriptional cell atlas. Cell Research. https://doi.org/10.1038/s41422-018-0099-2
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