Expression of CD39 on activated T cells impairs their survival in older individuals

Fang, Fengqin, Yu, Mingcan, Cavanagh, Mary M., Hutter Saunders, Jessica, Qi, Qian, Ye, Zhongde, Le Saux, Sabine, Sultan, William +5 more·2016·Cell Reports

Cited by (146)

Items 101–146 of 146

  1. Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
    Xin Huang, Yimin Khoong, Chengyao Han, Dai Su, Hao Ma, Shuchen Gu, Qingfeng Li, Tao Zan · 2021 · Frontiers in Physiology
  2. Genetically Driven CD39 Expression Affects Sezary Cell Viability and IL-2 Production and Detects Two Patient Subsets with Distinct Prognosis
    Mario Picozza, Cristina Cristofoletti, Antonella Bresin, Martina Fioretti, Manolo Sambucci, Enrico Scala, Alessandro Monopoli, Maria Cantonetti, Maria Antonietta Pilla, Maria Pina Accetturi et al. · 2022 · Journal of Investigative Dermatology
  3. CD73 as a T cell dysfunction marker predicting cardiovascular and infection events in patients undergoing hemodialysis
    Fangfang Xiang, Lin Sun, Xuesen Cao, Yang Li, Xiaohong Chen, Zhen Zhang, Jianzhou Zou, Jie Teng, Bo Shen, Xiaoqiang Ding · 2024 · Clinica Chimica Acta
  4. Relationship between immune cells and diabetic nephropathy: a Mendelian randomization study
    Xin Li, Liangyou Zhang, Chuang Yan, Huo Zeng, Gangyi Chen, Jianwen Qiu · 2024 · Acta Diabetologica
  5. PURINERGIC SIGNALING RECEPTORS EXPRESSION ON PERIPHERAL T-LYMPHOCYTES OF HEALTHY DONORS
    А. С. Головкин, M. K. Serebryakova, E. V. Zhiduleva, Patimat Murtazalieva, Victor A. Titov, O. B. Irtuga, О. М. Моисеева, Кробинец Ирина Ивановна, Igor Vladimirovich Kudryavtsev · 2017 · Translational Medicine
  6. Extracellular adenine compounds within the cardiovascular system: Their source, metabolism and function
    Gerald Soslau · 2019 · Medicine in Drug Discovery
  7. Damage response signaling by the extracellular adenosine pathway: control of infection outcome during host aging
    Manmeet Bhalla, Shaunna R. Simmons, Alexsandra P. Lenhard, Anagha Betadpur, Michael C. Battaglia, Elsa N. Bou Ghanem · 2025 · mSphere
  8. Combined High-Throughput Approaches Reveal the Signals Driven by Skin and Blood Environments and Define the Tumor Heterogeneity in Sézary Syndrome
    Cristina Cristofoletti, Antonella Bresin, Martina Fioretti, Giandomenico Russo, Maria Grazia Narducci · 2022 · Cancers
  9. Targeting CD73 and correcting adenosinergic signaling in critically ill patients
    Justin Mark Lunderberg, Alexander James Spicer, Jessica M. Cassavaugh, Juho M. Jalkanen, György Haskó, Simon Christopher Robson · 2026 · Frontiers in Pharmacology
  10. Immunological features of ESRD patients undergoing hemodialysis of various ages
    XiaoHong Chen, Fangfang Xiang, Xuesen Cao, WenLv Lv, Bo Shen, Jianzhou Zou, Xiaoqiang Ding · 2023 · International Urology and Nephrology
  11. Prostate Cancer Survivors Present Long-Term, Residual Systemic Immune Alterations
    Katalin Balázs, Zsuzsa S. Kocsis, Péter Ágoston, Kliton Jorgo, László Gesztesi, Gyöngyi Farkas, Gábor Székely, Zoltán Takácsi‐Nagy, Csaba Polgár, Géza Sáfrány et al. · 2022 · Cancers
  12. Bacterial vaginosis-driven changes in cervicovaginal immunity that expand the immunological hypothesis for increased HIV susceptibility
    Finn MacLean, Adino Tesfahun Tsegaye, Jessica B. Graham, Jessica L. Swarts, Sarah C. Vick, Nicole B. Potchen, Irene Cruz Talavera, Lakshmi Warrier, Julien Dubrulle, Lena K. Schroeder et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  13. SNP rs10748643 determines CD39 expression in T and NK cells through altering NFIC binding affinity rather than interfering with RNA splicing
    Chenxin Gan, Qian Vicky Wu, Jörg J. Goronzy, Yongchun Zhang, Lingjie Li, Huiming Sheng, Fengqin Fang · 2025 · Frontiers in Immunology
  14. Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae
    Michael C. Battaglia, Manmeet Bhalla, Brandon J. Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat Can Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron et al. · 2026 · Aging Cell
  15. Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
    Yin Zhang, Xianzhe Yu, Ping Li, Yaobin Ouyang, Lingling Zhu, Fengming Luo · 2026 · BMC Medicine
  16. Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn’s disease lesions
    Ján Deván, Vladimir Nosi, Julian Spagnuolo, Andrew Chancellor, Aisha Beshirova, José Pedro Loureiro, Alessandro Vacchini, Jan Hendrik Niess, Raffaele Calogero, Lucia Mori et al. · 2023 · Clinical & Experimental Immunology
  17. CD39 deletion in TCR-engineered T cells enhances antitumour immunity
    Alexander K. Tsai, Ingunn M. Stromnes · 2023 · Gut
  18. The FluPRINT dataset: A multidimensional analysis of the influenza vaccine imprint on the immune system
    Adriana Tomić, Ivan Tomic, Cornelia L. Dekker, Holden Terry Maecker, Mark M. Davis · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  19. CD39-CD73-adenosine effects in Sézary syndrome
    Sean J Whittaker, Christine L. Jones · 2023 · Blood
  20. Development and validation of a cell-based assay to determine the bioactivity of antibodies against CD39 targets
    Gangling Xu, Yongbo Ni, Chunbo Cui, Jialiang Du, Maoqin Duan, Yalan Yang, Chuanfei Yu · 2025 · Journal of Pharmaceutical and Biomedical Analysis
  21. Therapeutic approaches to delay lung aging: understanding cellular and immune system changes in the older adults
    Yumeng Lin, Mengjun Yan, Lili Shen, Yi Wang, Hailan He, Zhongyu Han, Haoran Chen, Aijun Liu · 2025 · The Journals of Gerontology Series A
  22. Genital herpes shedding episodes associate with altered spatial organization and activation of mucosal immune cells
    Finn MacLean, Rachael M. Zemek, Adino Tesfahun Tsegaye, Jessica B. Graham, Jessica L. Swarts, Sarah C. Vick, Nicole B. Potchen, Irene Cruz Talavera, Lakshmi Warrier, Julien Dubrulle et al. · 2025 · JCI Insight
  23. Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation
    Y H Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu et al. · 2025 · Small Science
  24. Assessment of CD4+ cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis
    Д. Г. Купцова, Т. В. Радыгина, С. В. Петричук, Nikolay N. Murashkin, Хотко Алкес Асланчериевич, Roman A. Ivanov · 2022 · Medical Immunology (Russia)
  25. Influence of Age on Functional Memory T Cell Diversity
    Fengqin Fang, Wenqiang Cao, Weikang Zhu, Nora Lam, Lingjie Li, Sadhana Gaddam, Yong Wang, Chulwoo Kim, Simon Lambert, Huimin Zhang et al. · 2021 · SSRN Electronic Journal
  26. The STAT5-IRF4-BATF pathway drives heightened epigenetic remodeling in naïve CD4 + T cell responses of older adults
    Huimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel Nadine Goronzy, Jun Jin, William James Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Haem toxicity in the aged spleen impairs T-cell immunity through iron deprivation
    David Ezuz, Heba Ombashe, Lana watted, Orna Atar, Noga Ron‐Harel · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Multifactorial heterogeneity of virus-specific T cells : Complex relationships during the progression of human chronic hepatitis B infection
    Yang Cheng · 2018
  29. Análise da função supressora das células T reguladoras em episódios reacionais hansênicos
    Carolina Cardona Siqueira Lobo · 2019
  30. Genital herpes shedding episodes associate with alterations in the spatial organization and activation of mucosal immune cells
    Finn MacLean, Rachael M. Zemek, Adino Tesfahun Tsegaye, Jessica B. Graham, Jessica L. Swarts, Sarah C. Vick, Nicole B. Potchen, Irene Cruz Talavera, Lakshmi Warrier, Julien Dubrulle et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Etude des syndromes lymphoprolifératifs lymphocytaires T induits par un dysfonctionnement de l'adaptateur moléculaire LAT
    Anaïs Joachim · 2021 · theses.fr (ABES)
  32. Contribution des réponses immunitaires adaptatives spécifiques des antigènes tumoraux à l'efficacité clinique de l'immunothérapie par inhibition de l'axe PD-1/PD-L1
    Camille-Charlotte Balança · 2021 · theses.fr (ABES)
  33. Utility of combined CD39 / CD73 / CD38 expression for the detection of malignant T cells in Sézary syndrome
    Sara Marchisio, Yuliya Yakymiv, Liyun Lin, Erika Ortolan, Verdiana Pullano, Renata Ponti, Fenna J. de Bie, Alita J. van der Sluijs‐Gelling, Willem H. Zoutman, Valentina Pala et al. · 2026 · British Journal of Haematology
  34. Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function
    Emily Nicole Bitsko, David Joyner, Jeffrey R. Maslanka, Kyra Woloszczuk, Arden O. Edgerton, Matthew R. Bell, Christian Sell, Mohamad‐Gabriel Alameh, Joris Beld, Elias K. Haddad et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Augmenting CAR T cell functionality and metabolism through CD39 downtuning
    Dennis Christoph Harrer, Jeremy Baldwin, Markus Barden, Hong Pan, Bence Gergely, Árpád Szöőr, György Vereb, Wolfgang Herr, Hinrich Abken · 2026 · Molecular Therapy Oncology
  36. A Gut‐Centric View of Ageing: A Pilot Analysis Mapping Age‐Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics
    Jack Sullivan, Jessica Conway, Sophie J. Hopkin, Myriam Chimen, Niharika Arora Duggal · 2026 · Aging Cell
  37. Respiratory syncytial virus inhibits type I interferon signaling to maintain HLA-DM expression in CD1c+ dendritic cells
    W Y Ong, Richard Anthony Hopkins, Enjun Yang, Novita, Najwa Talib, Bijin Au, John Edward Connolly · 2026 · iScience
  38. B-cell Immunity to Influenza (SLVP017) 2013
    Mark M. Davis · 2020 · ImmPort
  39. B-cell Immunity to Influenza (SLVP017) 2011
    Mark M. Davis · 2020 · ImmPort
  40. Genital Tract and Circulating CD8+ T Cell Phenotypes Vary Across the Menstrual Cycle
    Irene Cruz Talavera, Katherine K. Thomas, Jessica B. Graham, Jessica L. Swarts, Sarah C. Vick, Finn MacLean, Nicole B. Potchen, Lakshmi Warrier, Adino Tesfahun Tsegaye, Sean M. Hughes et al. · 2026 · American Journal of Reproductive Immunology
  41. B-cell Immunity to Influenza (SLVP017) 2010
    Mark Davis · 2020 · ImmPort
  42. Role of CD4+ Memory Phenotype, Memory, and Effector T Cells in Vaccination and Infection (SLVP030)
    Cornelia Dekker · 2024 · ImmPort
  43. Immune Senescence: Comparison of Immune Response to Influenza Vaccine 2007 in Adults of Different Ages
    Mark Davis · 2024 · ImmPort
  44. Innate and Acquired Immunity to Influenza Infection and Immunization (SLVP029)
    Cornelia Dekker · 2024 · ImmPort
  45. Genetic and Environmental Factors in the Response to Influenza Vaccination 2014
    Cornelia Dekker · 2024 · ImmPort
  46. Plasmablast response to inactivated and live attenuated influenza vaccines (TIV3/TIV3 ID) in 2014
    Harry Greeb=nberg · 2024 · ImmPort