Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System

Geoffroy, Cédric G., Hilton, Brett J., Tetzlaff, Wolfram, Zheng, Binhai·2016·Cell Reports
DOI 10.1016/j.celrep.2016.03.028

Cited by (160)

Items 101–160 of 160

  1. Moving CNS axon growth and regeneration research into human model systems
    Bo P. Lear, Darcie L. Moore · 2023 · Frontiers in Neuroscience
  2. Knockdown of Porf-2 Restores Visual Function after Optic Nerve Crush Injury
    Di Chen, Yiyu Sun, Lai-Yang Zhou, Xu Han, Shuo Yang, Fei-Yang Hong, Yuan Yuan, Xiao-Hua Wu, Guohui Huang, Yuan-Chi Cheng et al. · 2022 · Cell Death and Disease
  3. RETRACTED: EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
    Gilberto Gonzalez, Lizhen Chen · 2021 · Cells · Retracted
  4. Functional Recovery Associated with Dendrite Regeneration in PVD Neuron of Caenorhabditis elegans
    Harjot Kaur Brar, Swagata Dey, Pallavi Singh, Devashish Pande, Anindya Ghosh‐Roy · 2024 · eNeuro
  5. Appropriate patient population for future visual system axon regeneration therapies
    Sanjoy K. Bhattacharya, Chrisfouad Raif Alabiad, Krishna S. Kishor · 2023 · WIREs Mechanisms of Disease
  6. Intraspinal and Intracortical Delivery of AAV Vectors for Intersectional Circuit Tracing in Non-transgenic Species
    James M. Conner, Greg L. Bain, Jennifer N. Dulin · 2019 · Methods in molecular biology
  7. Spontaneously regenerative corticospinal neurons in mice
    Benjamin W. Fait, Bianca Cotto, Tatsuya C. Murakami, Michael Hagemann-Jensen, Huiqing Zhan, Corinne Freivald, Isadora Turbek, Yuan Gao, Zizhen Yao, Sharon W. Way et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy
    Thomas J. Krzystek, Shermali Gunawardena · 2025 · Autophagy Reports
  9. Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway
    Qinghua Wang, Yuan-hu Shi, Liya Zhang, Wenwei Jiang, Yuan-xu Pu, Shiyuan Chen, Hua-qiang Song, Jiaqi Dai, Jiaxi Chen, Jin-yi Liu et al. · 2025 · Stem Cell Research & Therapy
  10. Novel Neurotrophin-3 peptidomimetic synthetic neurotrophin promotes neurological recovery after spinal cord injury
    Arthur Sefiani, Darijana Horvat, Thitima Pewklang, Tye Thompson, Seeta Morey, Asim Abdelfattah, Olivia Samaie, Jacob Hoar, Kevin Burgess, Cédric G. Geoffroy · 2026 · Experimental Neurology
  11. DEPENDENCE OF THE RESTORATIVE EFFECT OF MACROPOROUS POLY(N-[2-HYDROXYPROPYL]-METHACRYLAMIDE HYDROGEL ON THE SEVERITY OF EXPERIMENTAL LACERATIVE SPINAL CORD INJURY
    Ibrahim M. Abdallah, Volodymyr V. Medvediev, Nataliya Draguntsova, Nana V. Voitenko, Vitaliy Tsymbaliuk · 2021 · Ukrainian Scientific Medical Youth Journal
  12. Corticospinal tract regeneration after spinal cord injury: Implications for treatment and recovery
    Yuanyuan Li, Paul Lu · 2022 · Elsevier eBooks
  13. Identification of age‐specific biomarkers of spinal cord injury: A bioinformatics analysis of young and aged mice models
    Wei Miao, Zheng Su, Huilin Cheng · 2023 · Brain and Behavior
  14. Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
    Rui Feng, Sarah F. Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cédric G. Geoffroy, Valeria Cavalli · 2024 · eLife
  15. Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury
    Sarah A. Woller, Jörg Ruschel, Barbara Morquette, James P. Cardia, Dinxue Yan, Katherine Holton, Taisia Shmushkovich, Emily D. Niederst, Karen G. Bulock, Alexey D. Wolfson et al. · 2022 · iScience
  16. Morphological screens using aged primary adult neuronal, microglial, and astrocytic cultures to find novel neurotherapeutics
    Arthur Sefiani · 2023 · Frontiers in Cellular Neuroscience
  17. Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells
    Mahekta R. Gujar, Yang Gao, Xiang Teng, Qiannan Deng, Ye Sing Tan, Yusuke Toyama, Hongyan Wang · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Independent control of functional rewiring after axon injury by let-7 miRNA and insulin/insulin-like growth factor signaling pathways
    Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh‐Roy · 2025 · Journal of Biosciences
  19. Secretome Profiling in Axon Regeneration: Emerging Techniques and Therapeutic Translation
    Maria D. Cabrera, Nicole Ramones, Isabella Moceri, Sanjoy K. Bhattacharya · 2025 · Sensory Neuroscience
  20. Understanding the Role of Fibrotic Scarring in Shaping the Lesion Site and Neural Repair After Spinal Cord Injury
    Camilo J. Londoño, Binhai Zheng · 2026 · Cells
  21. Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
    Rui Feng, Sarah F. Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cédric G. Geoffroy, Valeria Cavalli · 2025 · eLife
  22. Selective, Intrinsically Fluorescent Trk Modulating Probes
    Thitima Pewklang, Tye Thompson, Arthur Sefiani, Cédric G. Geoffroy, Anyanee Kamkaew, Kevin Burgess · 2024 · ACS Chemical Neuroscience
  23. Probing regenerative heterogeneity of corticospinal neurons with scRNA-Seq
    Jae Mun Kim, Junmi M. Saikia, Katlyn Marie A. Monte, Eunmi Ha, Daniel Romaus‐Sanjurjo, Joshua Sanchez, Andrea Moore, Marc Hernaiz-Llorens, Carmine L. Chavez‐Martinez, Chimuanya K. Agba et al. · 2023 · Research Square
  24. The development and potential of spinal cord stem and progenitor cells
    Xiaofei Li · 2018 · Figshare
  25. TIR-1/SARM1 Inhibits Axon Regeneration
    Victoria Julian · 2021 · eScholarship@UMassChan
  26. Pharmacological Inhibition of PTEN, using BpV (Phen), Promotes Survival of Retinal Ganglion Cells In Vitro and In Vivo
    Dennis Chan · 2019
  27. The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria
    Theresa C. Sutherland, Arthur Sefiani, Darijana Horvat, Taylor E. Huntington, Yuanjiu Lei, Andrew Phillip West, Cédric G. Geoffroy · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.
    Malcolm Maden · 2021 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  29. Biomaterials and immunomodulation for spinal cord repair
    Martin Oudega, Inés Maldonado-Lasunción · 2021 · Elsevier eBooks
  30. Faculty Opinions recommendation of Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.
    Phillip G. Popovich · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  31. Faculty Opinions recommendation of Reprogramming to recover youthful epigenetic information and restore vision.
    Pinghua Liu · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  32. Faculty Opinions recommendation of Selective rab11 transport and the intrinsic regenerative ability of CNS axons.
    Phillip G. Popovich · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  33. Faculty Opinions recommendation of Advances and limitations of current epigenetic studies investigating mammalian axonal regeneration.
    Phillip G. Popovich · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  34. Faculty Opinions recommendation of Required growth facilitators propel axon regeneration across complete spinal cord injury.
    Michael George Fehlings · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  35. Corrigendum: Purinergic signaling systems across comparative models of spinal cord injury
    2022 · Neural Regeneration Research
  36. Optic nerve repair and regeneration in vertebrates
    YiFei LI, Kangxin Jin, Mengqing Xiang · 2022 · Scientia Sinica Vitae
  37. Hyperactive PI3Kinase delta enables long distance regeneration of the rat corticospinal tract
    Kristýna Kárová, Polcanova Zuzana, Stepanka Suchankova, L. W. Knight, Bart Nieuwenhuis, Radovan Holota, Vı́t Herynek, Lucia Machová Urdzíková, Rostislav Tureček, Jessica C. F. Kwok et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Synergistic control of axon regeneration and functional recovery by let-7 miRNA and Insulin signalling (IIs) pathways
    Sruthy Ravivarma, Sibaram Behera, Dipanjan Roy, Anindya Ghosh‐Roy · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
    Rui Feng, Sarah F. Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Cédric G. Geoffroy, Valeria Cavalli · 2024 · eLife
  40. Retinal/optic nerve gene expression data analysis for nonbioinformaticians
    Emily Victoria Adis, Sara Rodríguez, James Jarad Dollar, Stefan Kurtenbach · 2025 · Elsevier eBooks
  41. Extracellular Vesicle Metabolomics Holds Promise for Adult Axon Regeneration
    Marta González, Jackson Watson, Laura Leal, Isabella Moceri, Camille Plummer, Biraj Mahato, Abdelrahman Y. Fouda, Sanjoy K. Bhattacharya · 2025 · Metabolites
  42. Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
    Rui Feng, Sarah F. Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cédric G. Geoffroy, Valeria Cavalli · 2025 · eLife
  43. Additional file 6 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  44. Additional file 4 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Zhang, Xianjin, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  45. Additional file 2 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  46. Additional file 5 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  47. Additional file 8 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  48. Additional file 3 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  49. Additional file 1 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  50. Additional file 7 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
    Wang, Xiaoxiong, Wenxiang Li, Zhang, Jianping, Li, Jinze, Xianjin Zhang, Wang, Min, Wei, Zhijian, Feng, Shiqing · 2024 · Figshare
  51. Long-Term Expression and Safety of AAV1-Mediated PI3Kδ Overexpression in the Adult Rat Cortex
    L. W. Knight, Polcanova Zuzana, Dana Mareková, Lucia Machová Urdzíková, Daniel Jirák, Natalia Ziółkowska, Pavol Makovicky, Fred de Winter, Jessica C. F. Kwok, Pavla Jendelová et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Caractérisation des troubles de l’équilibre et effets d’un programme d’activités physiques adaptées chez les personnes âgées obèses
    Waël Maktouf · 2019
  53. Human and mouse spinal cord : a territory of diverse neural stem/progenitor cells, identification and functionality
    Hussein Ghazale · 2019
  54. Functional Outcome and Discharge Destination in Elderly Patients with Spinal Cord Injury: A Retrospective Cohort Study Manuscript Type: Original Article
    Stephan Kurz, Oliver Habich, Katja Brauer, Frederik Wilhelm Schneckmann · 2026 · Research Square
  55. A novel molluscan CNS organ culture for the examination of adult nerve regeneration
    Autumn Lif, Victoria Hawton, Gaynor E. Spencer · 2026 · Journal of Neuroscience Methods
  56. Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injury
    Mariajose Metcalfe, Oswald Steward, Daisy Gallardo · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Nano- and Microstructured Biomaterials for Spinal Cord Injury Repair: From Material Design to Neural Regeneration
    Keni Yang, Jiarong Lu, Yanyan Chen, Jianwu Dai · 2026 · ACS Nano
  58. Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System
    Arissa Adhikary, Emily A. Dorairaj, Alex Arshavsky, Shanti Ramcharan, Krishna S. Kishor, Sanjoy K. Bhattacharya · 2026 · Cells
  59. Functional outcome and discharge destination in older patients with spinal cord injury: a retrospective cohort study
    Stephan Kurz, Oliver Habich, Katja Brauer, Frederik Wilhelm Schneckmann · 2026 · European Geriatric Medicine
  60. Agrin‐Enriched Neonatal Spinal Cord‐Derived Extracellular Vesicles Bypass Age Barriers to Organize Spinal Cord Repair
    Yongfeng Zhang, Qi Liu, Beibei Yu, Borui Xue, Shijie Yang, Teng Ma, Lingli Guo, Haining Wu, Xue Gao, Shengyou Li et al. · 2026 · Journal of Extracellular Vesicles