Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9

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Items 101–200 of 264

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2. Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells
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3. Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells
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5. Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion
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6. Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells
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7. Interactions between lineage‐associated transcription factors govern haematopoietic progenitor states
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8. Strengthening the CAR‐T cell therapeutic application using CRISPR/Cas9 technology
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9. The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation
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10. Advantages and Limitations of Gene Therapy and Gene Editing for Friedreich’s Ataxia
    Anusha Sivakumar, Stéphanie Cherqui · 2022 · Frontiers in Genome Editing
11. Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
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12. Advances in the gene therapy of monogenic blood cell diseases
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13. ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes
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14. Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures
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15. Development of a Self-Restricting CRISPR-Cas9 System to Reduce Off-Target Effects
    Hui Wang, Hua A. Jenny Lu, Yingshou Lei, Chen-yu Gong, Zhao Chen, Ying-qiao Luan, Qiang Li, Ying-zhen Jian, Haozheng Wang, Fenglin Wu et al. · 2020 · Molecular Therapy — Methods & Clinical Development
16. Combined lentiviral- and RNA-mediated CRISPR/Cas9 delivery for efficient and traceable gene editing in human hematopoietic stem and progenitor cells
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17. N-acetyl-β-D-hexosaminidases mediate the generation of paucimannosidic proteins via a putative noncanonical truncation pathway in human neutrophils
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18. LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells
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19. Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response
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20. Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing
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21. Effector memory–type regulatory T cells display phenotypic and functional instability
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22. Galvanin (TMEM154) is an electric-field sensor for directed cell migration
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23. Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air–liquid interface
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24. ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment
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25. High-content CRISPR screening in tumor immunology
    Erin A. Holcomb, Ashley N. Pearson, Kassidy Mikala Jungles, Akshay Tate, Jadyn G. James, Long Jiang, Amanda K. Huber, Michael D. Green · 2022 · Frontiers in Immunology
26. <i>Txnip</i> Enhances Fitness of <i>Dnmt3a</i> -Mutant Hematopoietic Stem Cells via <i>p21</i>
    Zhang, Christine R., Ostrander, Elizabeth L., Kukhar, Ostap, Mallaney, Cates, Sun, Jiameng, Haussler, Emily, Celik, Hamza, Koh, Won Kyun, King, Katherine Y., Gontarz, Paul et al. · 2022 · Blood Cancer Discovery
27. A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia
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28. Therapy-Resistant Acute Myeloid Leukemia Stem Cells Are Resensitized to Venetoclax + Azacitidine by Targeting Fatty Acid Desaturases 1 and 2
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29. Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases
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30. Safe and Effective In Vivo Targeting and Gene Editing in Hematopoietic Stem Cells: Strategies for Accelerating Development
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31. Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells
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32. Modeling clonal hematopoiesis in umbilical cord blood cells by CRISPR/Cas9
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33. SON is an essential m6A target for hematopoietic stem cell fate
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34. Application of Genome Editing Techniques in Immunology
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35. A Versatile Tool for the Quantification of CRISPR/Cas9-Induced Genome Editing Events in Human Hematopoietic Cell Lines and Hematopoietic Stem/Progenitor Cells
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36. In vitro transcribed sgRNA causes cell death by inducing interferon release
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37. Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity
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38. Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors
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39. Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients
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40. In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery
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41. Host genetics in malaria: lessons from mouse studies
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42. A fetal tumor suppressor axis abrogates MLL-fusion-driven acute myeloid leukemia
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43. Efficient gene correction of an aberrant splice site in β‐thalassaemia iPSCs by CRISPR/Cas9 and single‐strand oligodeoxynucleotides
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44. Caspase-2 regulates S-phase cell cycle events to protect from DNA damage accumulation independent of apoptosis
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45. NF-κB signaling controls H3K9me3 levels at intronic LINE-1 and hematopoietic stem cell genes in cis
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46. FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation
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47. Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma
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48. Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis
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49. Strategies to Genetically Modulate Dendritic Cells to Potentiate Anti-Tumor Responses in Hematologic Malignancies
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50. BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway
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51. CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill Myeloid Leukemia and Lymphoma Cells In Vitro Even after Extended Culture
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52. Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms
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53. Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
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54. CRISPR/Cas9 in epigenetics studies of health and disease
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55. Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9
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56. Non-viral ex vivo genome-editing in mouse bona fide hematopoietic stem cells with CRISPR/Cas9
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57. Neutrophil‐like HL‐60 cells expressing only GFP‐tagged β‐actin exhibit nearly normal motility
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58. CRISPR/Cas9 genome engineering in hematopoietic cells
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59. Human erythroblasts with c-Kit activating mutations have reduced cell culture costs and remain capable of terminal maturation
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60. In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis
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61. Toward precise CRISPR DNA fragment editing and predictable 3D genome engineering
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62. Systems-level conservation of the proximal TCR signaling network of mice and humans
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63. KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
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64. FAT1 expression in T-cell acute lymphoblastic leukemia (T-ALL) modulates proliferation and WNT signaling
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65. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing
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66. The Combinational Use of CRISPR/Cas9 and Targeted Toxin Technology Enables Efficient Isolation of Bi-Allelic Knockout Non-Human Mammalian Clones
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67. Genome editing using preassembled CRISPR-Cas9 ribonucleoprotein complexes in Fusarium graminearum
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68. A culture platform to study quiescent hematopoietic stem cells following genome editing
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69. CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases
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70. Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex
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71. Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia
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72. CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2 - and TET2 -mutant Cells
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74. Optimized Guide RNA Selection Improves Streptococcus pyogenes Cas9 Gene Editing of Human Hematopoietic Stem and Progenitor Cells
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75. Automated Good Manufacturing Practice-Compatible CRISPR-Cas9 Editing of Hematopoietic Stem and Progenitor Cells for Clinical Treatment of β-Hemoglobinopathies
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76. Codanin-1 mutations engineered in human erythroid cells demonstrate role of CDAN1 in terminal erythroid maturation
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77. Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
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78. Droplet Digital PCR for Oncogenic KMT2A Fusion Detection
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79. Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
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80. Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling
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81. Hematopoietic stem and progenitors cells gene editing: Beyond blood disorders
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82. gRNA Design: How Its Evolution Impacted on CRISPR/Cas9 Systems Refinement
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83. CRISPR/Cas9 applications in gene therapy for primary immunodeficiency diseases
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84. β-Hemoglobinopathies: The Test Bench for Genome Editing-Based Therapeutic Strategies
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85. Gene knockout in highly purified mouse hematopoietic stem cells by CRISPR/Cas9 technology
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86. Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice
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87. Innovative gene engineering and drug delivery systems for dendritic cells in cancer immunotherapy
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88. Genetic Therapies for Sickle Cell Disease
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89. In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery
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90. Recent Research Trends in Stem Cells Using CRISPR/Cas-Based Genome Editing Methods
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91. CRISPR/Cas9-targeting of CD40 in hematopoietic stem cells limits immune activation mediated by anti-CD40
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92. Restoring T and B cell generation in X-linked severe combined immunodeficiency mice through hematopoietic stem cells adenine base editing
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93. CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex
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94. TALEN mediated gene editing in a mouse model of Fanconi anemia
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95. Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells
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96. From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques
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97. Highly efficient site-directed gene insertion in primary human natural killer cells using homologous recombination and CRISPaint delivered by AAV
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