T cell migration from inflamed skin to draining lymph nodes requires intralymphatic crawling supported by ICAM-1/LFA-1 interactions

The Introduction (page unavailable) reports that T-cell crawling within inflamed afferent lymphatics depends on ICAM-1 and the T-cell integrin LFA-1. The Discussion (page unavailable) says whether this movement depends on a CCL21 gradient remains to be investigated; the paper does not establish haptotaxis or chemotaxis as its mediators. Its findings concern T cells during inflammation, not immunocytes generally. (LLM, conf=0.88)

The section “T Cells Crawl within Lymphatic Capillaries and Flow within Lymphatic Collectors” reports that T cells actively crawl after entering dermal lymphatic capillaries. The Discussion does not establish an initially random phase followed by directed crawling to the lymph node: it describes patrolling within capillaries and passive transport to the node after cells reach collecting vessels. The observations concern T cells, not immunocytes generally. (LLM, conf=0.88)

The in vitro results report that ICAM-1 blockade inhibited T-cell adhesion to and transmigration across lymphatic endothelium, supporting an integrin-related role in T-cell entry. But the Discussion says T-cell entry into lymphatic vessels was not directly tested in vivo, and the paper provides no finding about neutrophil entry. (LLM, conf=0.86)

In “T Cells Crawl within Lymphatic Capillaries and Flow within Lymphatic Collectors” (page not provided), the paper reports that T cells detach and are drawn into pumping collector vessels; the Discussion says lymph fluid then carries them to draining lymph nodes. It does not identify the vessels as precollectors or specify the subcapsular sinus (SCS) as their destination, and its direct observations concern T cells rather than immunocytes generally. (LLM, conf=0.87)