Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Open accessAbstract
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
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Pyramidal cells in the cortical plate express Nrg3, which facilitates laminar dispersion of cortical interneurons.
“In addition, recent work suggests that pyramidal cells in the cortical plate express a different member of the neuregulin family, Nrg3, and this molecule facilitates the dispersion of cortical interneurons in the laminar dimension of the cortex (Bartolini et al., 2017).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Bartolini et al., 2017
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References 92 · Cited by 74
Research works printed but not linked: 1
- Rakić S. Kanatani S. Hunt D. Faux C. Cariboni A. Chiara F. Khan S. Wansbury O. Howard B. Nakajima K. Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons Cereb. Cortex 25 2015 991 1003 24142862 PMC4380000
- Authors
- Bartolini, G., Sánchez-Alcañiz, J. A., Osório, C., Valiente, M., García-Frigola, C., & Marín, O.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- King's College London (GB)
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 18
- Issue
- 5
- Pages
- 1157-1170
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5300889
- OpenAlex
- W2584733781
- Cited by
- 74
- References
- 92
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 9 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 3
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Funders
- European Research Council (ERC-2011-AdG 293683)
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- NRG3, GABAergic interneurons, cortical plate, cortical lamination, interneuron migration, ErbB4, pyramidal neurons, inhibitory circuits, cortical development, chemoattractant signaling
- MeSH terms
- Animals, Cell Movement, Cerebral Cortex, Interneurons, Mice, Inbred C57BL, Signal Transduction, Pyramidal Cells, Receptor Protein-Tyrosine Kinases, Neuregulins, Intracellular Signaling Peptides and Proteins, Mice, GABAergic Neurons, Receptor, ErbB-4
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