β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares
Goldberg, Emily L., Asher, Jennifer L., Molony, Ryan D., Shaw, Albert C., Zeiss, Caroline J., Wang, Chao, Morozova-Roche, Ludmilla A., Herzog, Raimund I. +2 more·2017·Cell Reports
Cited by (374)
Items 301–374 of 374
- Intérêt du régime cétogène dans la prise en charge de la maladie d’AlzheimerAnouk Charlot, Alix Lernould, Irène Plus, Joffrey Zoll · 2023 · Biologie Aujourd hui
- Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged miceNing Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang · 2024 · eLife
- β-hydroxybutyrate attenuates diabetic renal and muscular pathologies in a streptozotocin-induced diabetic modelRahmawati Aisyah, Shohei Katsuya, Kenshu Miyata, Zhenhgyu Chen, Mayu Horii, Ayane Kudo, Thanutchaporn Kumrungsee, Jun Tsubota, Noriyuki Yanaka · 2025 · Nutrition
- Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disordersUlrika Hylén, Eva Särndahl, Susanne Bejerot, Mats B. Humble, Tuulia Hyötyläinen, Samira Salihović, Daniel Eklund · 2023 · BMC Psychiatry
- Neutrophil-derived S100A8/A9 promotes apoptosis of intestinal epithelial cells in children with duodenal ulcersRong Cheng, Xiaowei Xia, Rong Liu, Wenjun Zhang, Juan Du, Mao-yan Zhang, Chuanying Li · 2023 · Aging
- A Bibliometric Analysis of Research Trends in Soursop (Annona muricata Linn) Juice and Uric Acid Levels in Gout Arthritic DiseaseDila Fatiha Sholiha, Dwi Sarbini · 2023 · Advances in health sciences research/Advances in Health Sciences Research
- Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative DrugsGiulia Zudeh, Sara Sossai, Jacopo Angelini, Gabriele Stocco, Marianna Lucafò · 2025 · Frontiers in Bioscience-Landmark
- Association between ketogenic diet and gout among U.S. adults with diabetesLiujie Zheng, G. Li, Yan Liu, Zhiyong Hou · 2026 · International Journal of Surgery
- The Keto–Inflammatory Network: From Systems Biology to Biological CodeBurim Namik Ametaj · 2026 · Dairy
- Uric Acid as a Redox Switch in Gout: Linking Xanthine Oxidoreductase-Derived ROS, NLRP3 Inflammasome Activation and Emerging Ferroptotic MechanismsPetar-Preslav Svetlanov Petrov, Delyan Dimitrov, Darina Barbutska, Zlatina Nikolova, Nikoleta Dimitrova · 2026 · Antioxidants
- The effects of NLRP3 rs10754558 and rs4612666 polymorphisms on preeclampsia susceptibility, onset, and severity: a case-control study and in silico analysis.Mahnaz Rezaei, Marzieh Ghasemi, Mohsen Saravani, Rahele Ghasemian Moghadam, Hossein Shahraki-Ghadimi, Mahtab Norouzi, Saeedeh Salimi · 2024 · PubMed Central
- β-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in ratsRyohei Kawasaki, Asuka Sakata, Kohei Tatsumi, Seiji Mitani, Maiko Takeda, Shogo Kasuda, Naoki Matsumoto, Suguru Harada, Tetsuhiro Soeda, Yukiko Nishida et al. · 2024 · Scientific Reports
- Sex-Specific Anti-Inflammatory Effects of a Ketogenic Diet in a Mouse Model of Allergic Airway InflammationCarolyn Damilola Ekpruke, Omar A. Borges-Sosa, Christiane A. Hassel, Dustin Rousselle, Lyidia Dinwiddie, Maksat Babayev, Ahmed Olalekan Bakare, Patricia Silveyra · 2025 · International Journal of Molecular Sciences
- Inflammasome Activation by ParamyxovirusesNiraj Kanti Shil, Swechha Mainali Pokharel, Santanu Bose · 2017 · Current Clinical Microbiology Reports
- Ketogenic Diet, Inflammation, and EpilepsyDetlev Boison · 2021 · Progress in inflammation research
- Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity AthletesRiley Sonnenburg · 2018 · UWSpace (University of Waterloo)
- Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged miceNing Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang · 2024 · eLife
- Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic AcidsMadeleine M. Mank, Kaitlyn A Zoller, V. Amanda Fastiggi, Jennifer L. Ather, Matthew E. Poynter · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Peer Review #1 of "Optimization of extraction conditions and determination of purine content in marine fish during boiling (v0.1)"2019 · PeerJ
- Therapeutic ketosis for mild traumatic brain injuryJames Emery Joseph Crownover, A. Maleah Holland · 2019 · Translational Sports Medicine
- Macrophage Nourishment in Nonalcoholic Steatohepatitis: A Novel Role for Ketone BodiesNatalie Julia Torok · 2019 · Hepatology
- Environmental Impact on Lifelong Immunity: The Role of Infection and Nutrition in Host HomeostasisNico A. Contreras · 2019 · UA Campus Repository (The University of Arizona)
- β-Hydroxybutyrate Reduces Psoriasiform DermatitisToshihiko Mochizuki, Tomomitsu Miyagaki, Mayumi Tamaki, Sora Takeuchi, Takafumi Kadono · 2020 · Journal of St Marianna University
- Inhibitory effect of short-term ketogenic diet on cytokine expression during orthodontic movement in a rat modelEhsan Talebi, Jan Michael Silvosa-Antes, Mohamed A.M. Alsadig, Hsin‐Ming Chen, Gary A. Estomaguio · 2021 · Orthodontic Waves
- Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and goutMargarita Aleksandrovna Gromova, Vladimir Viktorovich Tsurko, O. A. Кislyak, Е. В. Киселева · 2021 · Modern Rheumatology Journal
- Ketone Supplementation for Health and DiseaseAngela M. Poff, Shannon Kesl, Andrew Paul Koutnik, Sara E. Moss, Christopher Q. Rogers, Dominic P. D’Agostino · 2022
- Peer Review #2 of "Optimization of extraction conditions and determination of purine content in marine fish during boiling (v0.1)"2019 · PeerJ
- Jeûne et inflammationHang‐Korng Ea, Alan Gauffenic, Chinh Nghia Pham · 2022 · Elsevier eBooks
- Protocol for a randomized controlled trial comparing a very low-carbohydrate diet or moderate-carbohydrate plate-method diet for type 2 diabetes: the LEGEND (Lifestyle Education about Nutrition for Diabetes) trialLaura R. Saslow, Adriana Eslamian, Patricia J. Moran, Wendy Hartogensis, Ashley E. Mason, Sarah Kim, Douglas C. Bauer, Dina Hafez, Veronica M. Goldman, Vivian Liu et al. · 2023 · Trials
- Three New Clerodane Diterpenoids and Their NLRP3 Inflammasome Activation Inhibitory Activity from Callicarpa arborea RoxbMuhammad Aurang Zeb, Ling Ding, Meng‐Ru Wang, Wen‐Chao Tu, Xiaoli Li, Xing‐Jie Zhang, Wei‐Lie Xiao · 2023 · Chemistry & Biodiversity
- Exosomal lincRNA-p21/AIF-1 promoted inflammation of human tubular epithelial cell via CMPK2/NLRP3 pathway in urate nephropathyJianbing Hao, Xinyu Guo, Siyu Wang, Xiaojun Guo, Kun Yuan, Ruihong Chen, Lirong Hao · 2024 · Research Square
- Sustained drug delivery to reduce the extent of burn progressionMoogaambikai D/O Thangaveloo · 2024
- Inflammasomes, Inflammation and Neuropathic PainLokesh Sharan, Anubrato Pal, Priya Saha, Ashutosh Kumar · 2024 · BENTHAM SCIENCE PUBLISHERS eBooks
- Additional file 3 of Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrateJin Chen, Li, Zihua, Yudian Zhang, Xu Zhang, Shujie Zhang, Zonghan Liu, Huimei Yuan, Xiangsheng Pang, Yaxuan Liu, Wuchen Tao et al. · 2022 · Figshare
- Additional file 2 of Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrateJin Chen, Zihua Li, Yudian Zhang, Xu Zhang, Shujie Zhang, Zonghan Liu, Huimei Yuan, Xiangsheng Pang, Yaxuan Liu, Wuchen Tao et al. · 2022 · Figshare
- Ketolysis Activates T Cell Function Against Staphylococcus Aureus Infection by Fueling the Tricarboxylic Acid (TCA) Cycle and Affecting Histone AcetylationHuanhuan Cai, Hao Zeng, Yingbo Chen, Xiaoyu Chen, Shuo Rong, Hao Luo, Yuxin Zhan, Lin Zhang, Zelong Li, Aihua Liao et al. · 2024 · SSRN Electronic Journal
- Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged miceNing Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang · 2024 · eLife
- Synthesis and Biological Evaluation of Novel Chlorogenic Acid–Apigenin Conjugates as Anti-acute Gout AgentsChangjiang Xu, Ling Li, Zheng Liu, Chuanqi Xie, Zhenya Zhai, Dong Liu, Wu Liu, Wei Xiong, Shengyong You · 2024 · Chemical and Pharmaceutical Bulletin
- Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged miceNing Song, Hang Gao, Jianhao Li, Yi Liu, Mingze Wang, Zhiming Ma, Naisheng Zhang, Wenlong Zhang · 2024 · eLife
- Metabolic regulators of crystal-induced arthritisChinh Nghia Pham, Charles Leroy, Hang‐Korng Ea · 2025 · Seminars in Arthritis and Rheumatism
- Healthcare professionals' perception of the ketogenic diet among patients with chronic obstructive pulmonary disease: a cross-sectional studySaleha Alqarni, Eatedal Eenizan Alsaeedi, Rayan A. Siraj, Yousef Saad Aldabayan, Amal Ismael Abdelhafez · 2025 · Frontiers in Nutrition
- Elafin inhibits macrophage activation by blocking a chloride channelXia Li, Longxin Chen, Na Chen, Liang Xu, Xiaoli Cui, Feng Wang · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- A Polyamine Takes the Fast Track to Attack Crystal‐Induced InflammationMónica Gumá, Robert A. Terkeltaub · 2025 · Arthritis & Rheumatology
- Additional file 4 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesFu, Weili, Ge, Minghao, Li, Jian · 2024 · Figshare
- Additional file 1 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesweili Fu, Ge, Minghao, Li, Jian · 2024 · Figshare
- Additional file 2 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disordersUlrika Hylén, Eva Särndahl, Bejerot, Susanne, Mats B. Humble, Tuulia Hyötyläinen, Salihovic, Samira, Daniel Eklund · 2023 · Figshare
- Additional file 1 of Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrateChen, Jin, Li, Zihua, Zhang, Yudian, Zhang, Xu, Zhang, Shujie, Liu, Zonghan, Huimei Yuan, Xiangsheng Pang, Liu, Yaxuan, Wuchen Tao et al. · 2022 · Figshare
- Additional file 5 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesFu, Weili, Ge, Minghao, Li, Jian · 2024 · Figshare
- Additional file 1 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disordersUlrika Hylén, Eva Särndahl, Bejerot, Susanne, Mats B. Humble, Tuulia Hyötyläinen, Salihovic, Samira, Daniel Eklund · 2023 · Figshare
- Additional file 2 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesweili Fu, Ge, Minghao, Li, Jian · 2024 · Figshare
- Additional file 3 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesFu, Weili, Ge, Minghao, Li, Jian · 2024 · Figshare
- Additional file 3 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disordersUlrika Hylén, Eva Särndahl, Bejerot, Susanne, Mats B. Humble, Tuulia Hyötyläinen, Salihovic, Samira, Daniel Eklund · 2023 · Figshare
- Additional file 6 of Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studiesFu, Weili, Ge, Minghao, Li, Jian · 2024 · Figshare
- β-Hydroxybutyrate impairs the functional response of bovine neutrophils to mammary pathogenic Staphylococcus aureus and a TLR2/1 agonist by limiting glucose metabolismJohn Quiroga, Rafael Agustin Burgos, C. Henríquez, María Daniella Carretta, P. Alarcón, Armin Mella, B. Guíñez, G. Morán · 2026 · Journal of Dairy Science
- Effect of Oral Ketone Body Intake on Human CD8+ T-Cell ImmunometabolismDavid Effinger, Simon Hirschberger, Thore Arntjen, Michaela Zell, Lesca Miriam Holdt, Simone Kreth · 2026 · Nutrients
- Ketone body metabolism activates the immune response against Staphylococcus aureus infection by fueling the tricarboxylic acid cycle and affecting histone β-hydroxybutyrylationHuanHuan Cai, Xin Yue, Yingbo Chen, Xi Chen, Renbo Qiao, Gechang Zhong, Shuo Rong, Lin Zhang, Zelong Li, Aihua Liao et al. · 2026 · Cell Insight
- Rôle de l'inflammation locale dans le développement des lésions causées par Mycobacterium ulcerans et sa toxineMélanie Foulon · 2020
- IRF5 and the metabolic adaptations of adipose tissue macrophages upon metabolic stressLucie Orliaguet · 2022 · theses.fr (ABES)
- Inflammation, aging and chronic diseases : implication of inflammasomesFlorent Guerville · 2023 · theses.fr (ABES)
- Le métabolisme de l'inflammation dans les maladies microcristallinesChinh Nghia Pham · 2024
- Synergistic Treatment of Multiple Sclerosis by Ketogenic Diet and Vitamin DHehe (Jerry) Xiao · 2026 · Highlights in Science Engineering and Technology
- Acidosis enables the NLRP3 inflammasome-inhibiting effects of β-hydroxybutyrate and short-chain carboxylic acidsMadeleine M. Mank, Kaitlyn A Zoller, V. Amanda Fastiggi, Jennifer L. Ather, Matthew E. Poynter · 2026 · The Journal of Immunology
- Garlic Polysaccharides Ameliorate AOM/DSS-Induced Colon Tumorigenesis: A Multi-Omics Mechanistic StudyYongqiu Qi, Xiaoming Lu, Li Li, Zhenjia Zheng, Yiteng Qiao · 2026 · Foods
- Immune metabolic remodeling during exercise rehabilitation: Linking skeletal muscle regeneration, bone homeostasis, and systemic immune adaptationFei Wang, Wenjie Qin · 2026 · Tissue and Cell
- The 100 top-cited articles in gout: A bibliometric analysisZibing Zhao, Yuxing Wang, Huixin Yan, Jinying Zhao, Jiapeng Chai, Jiaxun Zhang, Cuijuan Li, Fuchun Wang · 2026 · Medicine
- Impact of the Tobacco‐Smoking Status on the Phagocyte‐Derived Generation of Reactive Oxygen Species: New Modification of the Whole‐Blood Chemiluminescence AssayValery A. Menshov, Nadezda G. Berdnikova, Dmitry V. Tsyganko, Olga I. Yablonskaya, Aleksei V. Trofimov · 2026 · Luminescence
- The Neuroimmune Nexus: Diet-Induced Obesity, Inflammation, and Diet-Modulated Recovery Following Traumatic Brain InjuryS. J. Burke, Danielle M. Galvin, Yvonne M. Nolan, Harriët Schellekens, Rebecca J. Henry · 2026 · Neurotrauma Reports
- β-Hydroxybutyrate: a renoprotective hormone in polycystic kidney diseaseJacob A. Torres, Elizabeth H. Sharpe, Thomas Weimbs · 2026 · American Journal of Physiology-Endocrinology and Metabolism
- Neutrophil Fate and Function in Gout: From Sterile Inflammation to ResolutionYundong Xu, Qianqian Yang, Jian Zhang, Rong Wang, Sanjin Zeng, Dashuai Tuo, Niqin Xiao, Heguo Yan, Bingbing Chen, Shengyi Zhao et al. · 2026 · International Journal of Molecular Sciences
- Ketogenic diet as a systems-level immunometabolic sensitization strategy in cancer therapy: integrating metabolism, immune reprogramming, microbiome dynamics, and epigenetic regulationMuhammad Shaheer Mannan, Muhammad Waqas Khan, Muhammad Abdul Haseeb Khan, Ahmed Javed, S F Hussain, Hudda Adil · 2026 · Medical Oncology
- Time-restricted feeding during the inactive phase vs. ad libitum feeding: diet-dependent effects on weight and metabolic markers in male Wistar ratsLadan Hajhamidiasl, Murat Baş, Özgür Yılmaz, Samed Ozer, Salim Yılmaz, Sedat Arslan · 2026 · Frontiers in Nutrition
- Trained immunity in chronic, relapsing and low-grade joint inflammationBrenda Kischkel, Sonia Nasi, Charles Leroy, Leo A. B. Joosten, Hang‐Korng Ea · 2026 · Nature Reviews Rheumatology
- BindingDB Entry 50021100: Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50017788: Synthesis and Pharmacological Evaluation of NewBindingDB · 2023 · UC San Diego