β-hydroxybutyrate deactivates neutrophil NLRP3 inflammasome to relieve gout flares

Goldberg, Emily L., Asher, Jennifer L., Molony, Ryan D., Shaw, Albert C., Zeiss, Caroline J., Wang, Chao, Morozova-Roche, Ludmilla A., Herzog, Raimund I. +2 more·2017·Cell Reports

Cited by (374)

Items 101–200 of 374

  1. Common and divergent molecular mechanisms of fasting and ketogenic diets
    Antonio Paoli, Grant M. Tinsley, Mark P. Mattson, Immaculata De Vivo, Ravi Dhawan, Tatiana Moro · 2023 · Trends in Endocrinology and Metabolism
  2. Alarmins S100A8/A9 promote intervertebral disc degeneration and inflammation-related pain in a rat model through toll-like receptor-4 and activation of the NF-κB signaling pathway
    Jinjian Zheng, Jianru Wang, Hui Liu, Fan Chen, Hongbin Wang, S. Chen, Julin Xie, Zhijie Zheng, Zhonghai Li · 2022 · Osteoarthritis and Cartilage
  3. An Epigenetic Insight into NLRP3 Inflammasome Activation in Inflammation-Related Processes
    Aroa Baragaño Raneros, Cristian Ruiz Bernet, Aida Bernardo Flórez, Beatriz Suárez-Álvarez · 2021 · Biomedicines
  4. The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation
    Yanglin Wu, Yun Teng, Chenhui Zhang, Ying H. Pan, Qin Zhang, Xu Hui Zhu, Naicheng Liu, Xinlin Su, Jun Lin · 2022 · Journal of Nanobiotechnology
  5. β-Hydroxybutyrate against Cisplatin-Induced acute kidney injury via inhibiting NLRP3 inflammasome and oxidative stress
    Shilu Luo, Ming Yang, Yachun Han, Hao Zhao, Na Jiang, Li Li, Wei Chen, Chenrui Li, Jinfei Yang, Yan Liu et al. · 2022 · International Immunopharmacology
  6. A ketogenic diet substantially reshapes the human metabolome
    David Effinger, Simon Hirschberger, Polina Yoncheva, Annika Schmid, Till Heine, Patrick Newels, Burkhard Schütz, Chen Meng, Michael Gigl, Karin Kleigrewe et al. · 2023 · Clinical Nutrition
  7. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma
    Alexandra Bernardo‐Colón, Victoria D. Vest, Adrienne Clark, Melissa Cooper, David John Calkins, Fiona Edith Harrison, Tonia S. Rex · 2018 · Cell Death and Disease
  8. Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic Diet
    Mari Murakami, Paola Tognini · 2022 · Nutrients
  9. A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
    Margaret Alexander, Vaibhav Upadhyay, Rachel Rock, Lorenzo Ramirez, Kai R. Trepka, Patrycja Puchalska, Diego A. Orellana, Qi Yan Ang, Caroline Whitty, Jessie A. Turnbaugh et al. · 2024 · Cell Reports
  10. Diabetes Mellitus, Energy Metabolism, and COVID-19
    Caterina Conte, Elisa Cipponeri, Michael Roden · 2023 · Endocrine Reviews
  11. Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model
    Takehiko Yamanashi, Masaaki Iwata, Midori Shibushita, Kyohei Tsunetomi, Mayu Nagata, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahiro A. Kato et al. · 2020 · Scientific Reports
  12. Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors
    Mona Mashayekhi, Bilgunay Ilkin Safa, Matthew S.C. Gonzalez, Sangwon F. Kim, Justin Basile Echouffo-Tcheugui · 2024 · Trends in Endocrinology and Metabolism
  13. Therapeutic alternative of the ketogenic Mediterranean diet to improve mitochondrial activity in Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review
    Jordi Caplliure‐Llopis, Thalía Peralta Chamba, Sandra Carrera‐Juliá, María Cuerda‐Ballester, Eraci Drehmer, María Mar López‐Rodriguez, José Enrique de la Rubia Ortí · 2019 · Food Science & Nutrition
  14. Metabolic Effects of Ketogenic Diets: Exploring Whole-Body Metabolism in Connection with Adipose Tissue and Other Metabolic Organs
    Ahmad, Yusra, Seo, Dong Soo, Jang, Younghoon · 2024 · International Journal of Molecular Sciences
  15. Research Progress of Mitochondrial Mechanism in NLRP3 Inflammasome Activation and Exercise Regulation of NLRP3 Inflammasome
    Tan Zhang, Shuzhe Ding, Ru Wang · 2021 · International Journal of Molecular Sciences
  16. Impact of fasting & ketogenic interventions on the NLRP3 inflammasome: A narrative review
    Helena Neudorf, Jonathan P. Little · 2023 · Biomedical Journal
  17. Intestinal toxicity alleviation and efficacy potentiation through therapeutic administration of Lactobacillus paracasei GY-1 in the treatment of gout flares with colchicine
    Jiaqi Zeng, Yan Li, Yizhi Zou, Ying Yang, Tingting Yang, Yizhuang Zhou · 2024 · Food & Function
  18. Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity
    Nan Qin, Guang Xu, Yan Wang, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, Chunyu Wang et al. · 2021 · Frontiers of Medicine
  19. Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors
    Yong‐ho Lee, Soo Kyung Lim, Melanie Jane Davies · 2025 · Nature Reviews Endocrinology
  20. Plasma Membrane Pores Drive Inflammatory Cell Death
    Benedikt Kolbrink, Theresa Riebeling, Ulrich Kunzendorf, Stefan Krautwald · 2020 · Frontiers in Cell and Developmental Biology
  21. Exogenous ketone supplementation: an emerging tool for physiologists with potential as a metabolic therapy
    Kaja Falkenhain, Hashim Islam, Jonathan P. Little · 2022 · Experimental Physiology
  22. Adaptive Metabolic Responses Facilitate Blood‐Brain Barrier Repair in Ischemic Stroke via BHB‐Mediated Epigenetic Modification of ZO‐1 Expression
    Ruijie Li, Yilin Liu, Jihao Wu, Xiong Chen, Qiying Lu, Kai Xia, Congyuan Liu, Xin Yuan Sui, Yixuan Liu, Yiling Wang et al. · 2024 · Advanced Science
  23. How Inflammation Blunts Innate Immunity in Aging
    Emily L. Goldberg, Albert C. Shaw, Ruth R. Montgomery · 2020 · Interdisciplinary topics in gerontology and geriatrics
  24. Importance of NLRP3 Inflammasome in Abdominal Aortic Aneurysms
    Jinyun Shi, Jia Guo, Zhidong Li, Baohui Xu, Masaaki Miyata · 2021 · Journal of Atherosclerosis and Thrombosis
  25. Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome Via B-hydroxybutyrate and Fibroblast Growth Factor 21
    Eun Ran Kim, So Ra Kim, Wonhee Cho, Sang‐Guk Lee, Soo Hyun Kim, Jin Hee Kim, Eunhye Choi, Jeong‐Ho Kim, Je‐Wook Yu, Byung‐Wan Lee et al. · 2022 · Frontiers in Immunology
  26. The case for a ketogenic diet in the management of kidney disease
    Shaminie J. Athinarayanan, Caroline G. P. Roberts, Chandan Vangala, Greeshma K. Shetty, Amy L. McKenzie, Thomas Weimbs, Jeff S. Volek · 2024 · BMJ Open Diabetes Research & Care
  27. Therapeutic implications of inflammasome in inflammatory bowel disease
    Vishal Khatri, Ramaswamy Kalyanasundaram · 2021 · The FASEB Journal
  28. Dietary and metabolic effects on intestinal stem cells in health and disease
    Jessica E.S. Shay, Ömer H. Yilmaz · 2024 · Nature Reviews Gastroenterology & Hepatology
  29. Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages
    Chun‐Ying Qiao, Ying Li, Yue Shang, Min Jiang, Jian Liu, Zi‐Ying Zhan, Huan Ye, Yong-Ce Lin, Jing-Ya Jiao, Rong-Hui Sun et al. · 2020 · Inflammopharmacology
  30. Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation
    Xiaorong Hou, Guang Xu, Zhilei Wang, Xiaoyan Zhan, Huifang Li, Ruisheng Li, Wei Shi, Chunyu Wang, Yuanyuan Chen, Yongqiang Ai et al. · 2020 · International Immunopharmacology
  31. Enemy or ally? Fasting as an essential regulator of immune responses
    Christoph Wilhelm, Jayagopi Surendar, Fotios Karagiannis · 2021 · Trends in Immunology
  32. On the nutritional and therapeutic effects of ketone body d-β-hydroxybutyrate
    Aliya Yao, LI Zi-hua, Jinyan Lyu, Liusong Yu, Wei Situ, Lingyun Xue, Hui Wang, Guo‐Qiang Chen · 2021 · Applied Microbiology and Biotechnology
  33. Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
    Curtis C. Hughey, Patrycja Puchalska, Peter A. Crawford · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  34. MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3
    Jianhui Tian, D Zhou, Li Xiang, Xiaoming Liu, Hu Zhang, Beibei Wang, B Xie · 2021 · Clinical & Experimental Immunology
  35. Approaching Neutrophil Pyroptosis
    Gabriel Sollberger · 2021 · Journal of Molecular Biology
  36. The neutrophil: A key resourceful agent in immune‐mediated vasculitis
    Karen Aymonnier, Jennifer Amsler, Peter Lamprecht, Alan David Salama, Véronique Witko‐Sarsat · 2022 · Immunological Reviews
  37. Britannin as a novel NLRP3 inhibitor, suppresses inflammasome activation in macrophages and alleviates NLRP3-related diseases in mice
    Jing-jing Shao, Weifeng Li, Jinfeng Sun, Zaishou Zhuang, Julian Min, Xiaohong Long, Gaojun Wu, Haowen Xu, Guang Liang · 2024 · Acta Pharmacologica Sinica
  38. Mechanism of reduced muscle atrophy via ketone body (D)-3-hydroxybutyrate
    Jin Chen, Zihua Li, Yudian Zhang, Xu Zhang, Shujie Zhang, Zonghan Liu, Huimei Yuan, Xiangsheng Pang, Yaxuan Liu, Wuchen Tao et al. · 2022 · Cell & Bioscience
  39. An open-label, randomized controlled trial to assess a ketogenic diet in critically ill patients with sepsis
    Tim Rahmel, David Effinger, Thilo Bracht, Leonore Griep, Björn Koos, Barbara Sitek, Max Hübner, Simon Hirschberger, Jale Basten, Nina Timmesfeld et al. · 2024 · Science Translational Medicine
  40. Anti‐inflammaging effects of human alpha‐1 antitrypsin
    Ye Yuan, Benedetto DiCiaccio, Ying Li, Ahmed Samir Elshikha, Denis Titov, Brian R. Brenner, Lee Seifer, Hope Pan, Nurdina Karic, Mohammad Ahsanul Akbar et al. · 2017 · Aging Cell
  41. A Novel Sex-Dependent Target for the Treatment of Postoperative Pain: The NLRP3 Inflammasome
    Ashley M. Cowie, Bonnie N. Dittel, Cheryl L. Stucky · 2019 · Frontiers in Neurology
  42. Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity
    Ziqi Liu, Xue Sun, Zibo Liu, Ting Zhang, Li-Lin Zhang, Chunjie Wu · 2022 · Journal of Pharmacy and Pharmacology
  43. High-fat diet exacerbates imiquimod-induced psoriasis-like dermatitis in mice
    Higashi, Yuko, Yamakuchi, Munekazu, Fukushige, Tomoko, Ibusuki, Atsuko, Hashiguchi, Teruto, Kanekura, Takuro · 2018 · Experimental Dermatology
  44. The role of dietary strategies in the modulation of hallmarks of aging
    Natasha Aparecida Grande de França, Yves Rolland, Sophie Guyonnet, Philipe de Souto Barreto · 2023 · Ageing Research Reviews
  45. Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis
    Shanshan Huang, Yaohui Wang, Shibo Lin, Wei Guan, Hui Liang, Jiajia Shen · 2023 · Frontiers in Endocrinology
  46. Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout
    Paloma Narros‐Fernández, Mourad Chioua, Sonia A. Petcu, Daniel Diez‐Iriepa, Laura Cerrada‐Gálvez, Celine Decouty‐Pérez, Alejandra Palomino‐Antolín, Eva Ramos, Víctor Farré‐Alins, Ana Belén López-Rodríguez et al. · 2022 · Journal of Medicinal Chemistry
  47. Dietary resistant starch preserved through mild extrusion of grain alters fecal microbiome metabolism of dietary macronutrients while increasing immunoglobulin A in the cat
    Matthew Irick Jackson, Christopher Waldy, Dennis Edward Jewell · 2020 · PLoS ONE
  48. Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets
    Damian Dyńka, Łukasz Rodzeń, Mateusz Rodzeń, Anna Pacholak-Klimas, Georgia Ede, Shebani Sethi, Dorota Łojko, Karolina Bartoń, Ken Berry, Adam Deptuła et al. · 2025 · Nutrients
  49. Ketogenic diet effects on inflammatory allodynia and ongoing pain in rodents
    David N. Ruskin, Isabella C. Sturdevant, Livia S. Wyss, Susan A. Masino · 2021 · Scientific Reports
  50. TCM and related active compounds in the treatment of gout: the regulation of signaling pathway and urate transporter
    Xin Sun, Le Yang, Hui Juan Sun, Ye Sun, Shuyun Wei, Ying Han, Wenkai Wang, Ling Dong Kong, Xijun Wang · 2023 · Frontiers in Pharmacology
  51. Nutrition and dietary restrictions in cancer prevention
    Amrendra Kumar Mishra, Giacomo Giuliani, Valter Daniel Longo · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  52. The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity
    Helena Neudorf, Étienne Myette‐Côté, Jonathan P. Little · 2020 · Nutrients
  53. Research progress of NLRP3 inflammasome and its inhibitors with aging diseases
    Zhuo Yuan, Dongke Yu, Tingting Gou, Guoyuan Tang, Chun Guo, Jianyou Shi · 2023 · European Journal of Pharmacology
  54. Translating Mechanism-Based Strategies to Break the Obesity−Cancer Link: A Narrative Review
    Laura A. Smith, Ciara H. O’Flanagan, Laura W. Bowers, Emma H. Allott, Stephen David Hursting · 2017 · Journal of the Academy of Nutrition and Dietetics
  55. How Changes in the Nutritional Landscape Shape Gut Immunometabolism
    Jian Tan, Duan Ni, Rosilene V. Ribeiro, Gabriela Veronica Pinget, Laurence Macia · 2021 · Nutrients
  56. Inflammasome Complexes: Crucial mediators in osteoimmunology and bone diseases.
    Feng Zhou, Guorui Zhang, Ying-Ying Wu, Yi Xiong · 2022 · International Immunopharmacology
  57. Disease-Associated Particulates and Joint Inflammation; Mechanistic Insights and Potential Therapeutic Targets
    Olwyn R. Mahon, Aisling Dunne · 2018 · Frontiers in Immunology
  58. NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development
    Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou, Mukut Sharma, Ram Sharma, Vikas Singh · 2024 · International Journal of Molecular Sciences
  59. Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies
    Weili Fu, Minghao Ge, Jian Li · 2023 · Journal of Translational Medicine
  60. Optimization of extraction conditions and determination of purine content in marine fish during boiling
    Tingting Li, Likun Ren, Dangfeng Wang, Minjie Song, Qiuying Li, Jianrong Li · 2019 · PeerJ
  61. β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
    Sidharth S. Madhavan, Stephanie Roa Diaz, Sawyer Peralta, Mitsunori Nomura, Christina D. King, Kaya E. Ceyhan, Anwen Lin, Dipa Bhaumik, Anna Foulger, Samah Shah et al. · 2024 · Cell chemical biology
  62. The ageing immune system as a driver of systemic ageing
    In Hwa Jang, Laura J. Niedernhofer, Paul D. Robbins, Christina D. Camell · 2026 · Nature reviews. Immunology
  63. Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction
    Lisa M. Weatherly, Hillary L. Shane, Sherri A. Friend, Ewa Lukomska, Rachel Baur, Stacey E. Anderson · 2020 · Toxicological Sciences
  64. Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation
    Emily L. Goldberg, Anudari Letian, Tamara Dlugos, Claire Leveau, Vishwa Deep Dixit · 2023 · Journal of Biological Chemistry
  65. Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-κB in monosodium urate-induced rat gouty arthritis
    Galih Aji Kuncoro Jati, Nazzun Assihhah, Anas Ardiana Wati, Siti Isrina Oktavia Salasia · 2022 · Veterinary World
  66. Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
    Daniel C. Shippy, Jyoti J. Watters, Tyler Kent Ulland · 2022 · BMC Genomics
  67. Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy
    Wendan Zhang, Honghong Jiang, Pengli Huang, Gaosong Wu, Qun Wang, Xin Luan, Hongwei Zhang, Dianping Yu, Hongru Wang, Dong Lu et al. · 2023 · Clinical and Translational Medicine
  68. NLRP3 Inflammasome and Inflammatory Response in Aging Disorders: The Entanglement of Redox Modulation in Different Outcomes
    Bhavana Chhunchha, Eri Kubo, Deepali Lehri, Dhirendra P. Singh · 2025 · Cells
  69. β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle
    Matías Monsalves‐Álvarez, Pablo Esteban Morales, Mauricio Castro‐Sepúlveda, Carlos Sepúlveda, Juan Manuel Rodriguez, Mario Chiong, Verónica Eisner, Sergio Lavandero, Rodrigo Troncoso · 2020 · Nutrients
  70. β-Hydroxybutyrate Oxidation Promotes the Accumulation of Immunometabolites in Activated Microglia Cells
    Adrián Benito, Nabil Hajji, Kevin O’Neill, Hector C. Keun, Nelofer Syed · 2020 · Metabolites
  71. β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption
    Yoshiki Hirata, Sayaka Shimazaki, Sae Suzuki, Yuka Henmi, Hiromu Komiyama, Takehito Kuwayama, Hisataka Iwata, Tadayoshi Karasawa, Masafumi Takahashi, Hironori Takahashi et al. · 2021 · Journal of Reproductive Immunology
  72. Potential Therapeutic Effects of Exogenous Ketone Supplementation for Type 2 Diabetes: A Review
    Jeremy James Walsh, Étienne Myette‐Côté, Helena Neudorf, Jonathan P. Little · 2020 · Current Pharmaceutical Design
  73. Serum lipidomics reveals distinct metabolic profiles for asymptomatic hyperuricemic and gout patients
    Shijia Liu, Yingzhuo Wang, Huanhuan Liu, Tingting Xu, Majie Wang, Jiawei Lu, Yunke Guo, Wenjun Chen, Mengying Ke, Guisheng Zhou et al. · 2021 · Lara D. Veeken
  74. 1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats
    Jeanne Ishimwe, Michael R. Garrett, Jennifer M. Sasser · 2020 · American Journal of Physiology-Renal Physiology
  75. Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral cortex
    Sahar Ahmed Mokhemer, Maha K Desouky, Asmaa K. Abdelghany, Manar Fouli Gaber Ibrahim · 2023 · Life Sciences
  76. Not just sugar: metabolic control of neutrophil development and effector functions
    Paul Ettel, Thomas Weichhart · 2024 · Journal of Leukocyte Biology
  77. Role of inflammasomes in acute respiratory distress syndrome
    Luke Flower, Emilio G. Vozza, Clare Elizabeth Bryant, Charlotte Summers · 2025 · Thorax
  78. TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization
    Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan et al. · 2022 · EMBO Reports
  79. Pyroptosis in inflammatory bone diseases: Molecular insights and targeting strategies
    Ruonan Zhang, Zhi‐Jun Sun, Lu Zhang · 2022 · The FASEB Journal
  80. Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4+ T Cell Responsiveness
    Kim Han, Komudi Singh, Matthew J. Rodman, Shahin Hassanzadeh, Yvonne Baumer, Rebecca D. Huffstutler, Jinguo Chen, Julián Candia, Foo Cheung, Katherine E. Stagliano et al. · 2021 · Nutrients
  81. Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy
    Mei-Hua Piao, Hui Wang, Yin-Jing Jiang, Yan‐Ling Wu, Ji‐Xing Nan, Li‐Hua Lian · 2022 · Inflammopharmacology
  82. Ketone bodies as chemical signals for the immune system
    Michelangelo Bauwelz Gonzatti, Emily L. Goldberg · 2024 · American Journal of Physiology-Cell Physiology
  83. Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity
    Chen He, Junkai Liu, Junda Li, Hongyu Wu, Chenyang Jiao, Xiaotong Ze, Shengtao Xu, Zheying Zhu, Wenjie Guo, Jinyi Xu et al. · 2024 · Journal of Medicinal Chemistry
  84. Comparison of lactate and β-hydroxybutyrate in the treatment of concanavalin-A induced hepatitis
    Sara H. Hazem, Mohamed F. Hamed, Mohamed A. Saad, Nariman M. Gameil · 2018 · International Immunopharmacology
  85. Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes
    Helena Neudorf, Hashim Islam, Kaja Falkenhain, Bárbara Oliveira, Garett S. Jackson, Alfonso Moreno‐Cabañas, Kenneth Michael Madden, Joel Singer, Jeremy James Walsh, Jonathan P. Little · 2024 · Clinical & Experimental Immunology
  86. Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation
    Denise Perez, Izabela Galvão, Rayssa Maciel Athayde, Bárbara Maximino Rezende, Juliana P. Vago, Julia D. Silva, Alesandra Côrte Reis, Lucas Secchim Ribeiro, José Hugo de Sousa Gomes, Rodrigo Maia de Pádua et al. · 2019 · European Journal of Immunology
  87. Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation
    Alisha Niskala, Jordi Heijman, Dobromir Dobrev, Thomas Jespersen, Arnela Saljic · 2024 · British Journal of Pharmacology
  88. Serum CA72-4 is specifically elevated in gout patients and predicts flares
    Xueshan Bai, Mingshu Sun, Yuwei He, Ruhua Liu, Lingling Cui, Can Wang, Fang Wan, Ming Wang, Xinde Li, Hailong Li et al. · 2020 · Lara D. Veeken
  89. Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study
    Yuanyu Chen, Yongzhong Yang, Ziwei Zheng, Hui Wang, Xuelin Wang, Zhikang Si, Rui Meng, Guoli Wang, Jianhui Wu · 2022 · BMC Public Health
  90. The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations
    Lavinia Agra Coletto, Chiara Rizzo, Giuliana Guggino, Roberto Felice Caporali, Stefano Alivernini, Maria Antonietta D’Agostino · 2023 · International Journal of Molecular Sciences
  91. Nod-like receptors in inflammatory arthritis
    Sahib Singh Madahar, A Rodan Gideon, Ali A. Abdul Sater · 2023 · Biomedical Journal
  92. From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience
    Brianna J. Stubbs, Andrew Paul Koutnik, Jeff S. Volek, John C. Newman · 2020 · GeroScience
  93. Microbiota fasting-related changes ameliorate cognitive decline in obesity and boost ex vivo microglial function through the gut-brain axis
    Virginia Mela, Violeta Heras, Monika Iešmantaitė, Maria Luisa García‐Martín, Manuel Bernal, Joel D. Posligua-García, Alba Subiri-Verdugo, José Ignacio Martínez‐Montoro, Ana María Gómez‐Pérez, Borja Bandera et al. · 2025 · Gut
  94. Folic acid-modified lysozyme protected gold nanoclusters as an effective anti-inflammatory drug for rapid relief of gout flares in hyperuricemic rats
    Jiachen Sun, Pengfei Zhuang, Shan Wen, Minghao Ge, Zipeng Zhou, Dan Li, Chang Liu, Xifan Mei · 2022 · Materials & Design
  95. Emerging Pathophysiological Roles of Ketone Bodies
    Hiroaki Tsuruta, Kosuke Yamahara, Mako Yasuda‒Yamahara, Shinji Kume · 2024 · Physiology
  96. Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome
    Ajay Tambralli, Alyssa Harbaugh, Somanathapura K. NaveenKumar, Megan D. Radyk, Christine E. Rysenga, Kaitlyn Sabb, Julia M. Hurley, Gautam J. Sule, Srilakshmi Yalavarthi, Shanea K. Estes et al. · 2024 · Journal of Clinical Investigation
  97. Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice
    Runping Duan, Tianfu Wang, Zhaohuai Li, Loujing Jiang, Xiaoyang Yu, Daquan He, Tianyu Tao, Xiuxing Liu, Zhaohao Huang, Lei Feng et al. · 2024 · Journal of Neuroinflammation
  98. Therapeutic ketosis decreases methacholine hyperresponsiveness in mouse models of inherent obese asthma
    Madeleine M. Mank, Leah F. Reed, Camille J. Walton, Madison L. T. Barup, Jennifer L. Ather, Matthew E. Poynter · 2021 · American Journal of Physiology-Lung Cellular and Molecular Physiology
  99. Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis
    Katarzyna Zyla, Dorothy A. Walton, Kendra S. Plafker, Susan Kovats, Constantin Georgescu, Richard S. Brush, Madison Tytanic, Martin‐Paul Agbaga, Scott M. Plafker · 2023 · Frontiers in Neurology
  100. Exerkines mitigating Alzheimer's disease progression by regulating inflammation: Focusing on macrophage/microglial NLRP3 inflammasome pathway
    Jaehwan Cheon, Soon-Yong Kwon, Mikyung Kim · 2024 · Alzheimer s & Dementia