Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Platt, Randall J., Zhou, Yang, Slaymaker, Ian M., Shetty, Ashwin S., Weisbach, Niels R., Kim, Jin-Ah, Sharma, Jitendra, Desai, Mitul +5 more·2017·Cell Reports
DOI 10.1016/j.celrep.2017.03.052

Cited by (239)

Items 101–200 of 239

  1. CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis
    Song Ding, Xianchun Lan, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li, Jian Chen, Wei Jiang · 2021 · Cell Death and Disease
  2. Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder
    Tanushree Shivaswamy, Rimenez Rodrigues de Souza, Crystal T. Engineer, Christa K. McIntyre · 2022 · Journal of Psychiatry and Brain Science
  3. An ultra-compact promoter drives widespread neuronal expression in mouse and monkey brains
    Jingyi Wang, Jianbang Lin, Yefei Chen, Jing Liu, Qiongping Zheng, Deng Mao, Ruiqi L. Wang, Yujing Zhang, Shijing Feng, Zhenyan Xu et al. · 2023 · Cell Reports
  4. Epigenetic underpinnings of the autistic mind: Histone modifications and prefrontal excitation/inhibition imbalance
    Yasaman Arman Fard, Elham Najjar Sadeghi, Zohreh Pajoohesh, Zahra Gharehdaghi, Dorsa Mousavi Khatibi, Shaghayegh Khosravifar, Yasamin Pishkari, Shadi Nozari, Ahmed Hijazi, SeyedAbbas Pakmehr et al. · 2024 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
  5. CHD8short, a naturally-occurring truncated form of a chromatin remodeler lacking the helicase domain, is a potent transcriptional coregulator
    Gary R. Kunkel, Jessica A. Tracy, Frank L. Jalufka, Arne C. Lekven · 2017 · Gene
  6. Chromatin modification and epigenetic control in functional nerve regeneration
    Kalen Berry, Qing Richard Lu · 2019 · Seminars in Cell and Developmental Biology
  7. RETRACTED ARTICLE: Overexpression of microRNA-221 promotes the differentiation of stem cells from human exfoliated deciduous teeth to neurons through activation of Wnt/β-catenin pathway via inhibition of CHD8
    Bing Wen, Chenjiang He, Qin Zhang, Fanglin Zhang, Na Li, Yan Pan, Mengting Deng, Yue Wang, Jianping Li, Jiaxuan Qiu · 2020 · Cell Cycle · Retracted
  8. Neurodevelopmental functions of CHD8: new insights and questions
    M. Albert Basson · 2024 · Biochemical Society Transactions
  9. A spontaneous missense mutation in the chromodomain helicase DNA‐binding protein 8 (CHD8) gene: a novel association with congenital myasthenic syndrome
    C. Y. Lee, Mina V. Petkova, Susanne Morales-Gonzalez, Niclas Gimber, Jan Schmoranzer, Andreas Meisel, Wolfgang Boehmerle, Werner Stenzel, Markus Schuelke, Jana Marie Schwarz · 2020 · Neuropathology and Applied Neurobiology
  10. Using an aquatic model, Xenopus laevis , to uncover the role of chromodomain 1 in craniofacial disorders
    Brent H. Wyatt, Thomas O. Raymond, Lisa A. Lansdon, Benjamin W. Darbro, Jeffrey Clark Murray, John Robert Manak, AMANDA J.G. DICKINSON · 2020 · genesis
  11. Exploring the role of RALYL in Alzheimer’s disease reserve by network-based approaches
    Yixuan Zhang, Jiali Wang, Xiaoquan Liu, Haochen Liu · 2020 · Alzheimer s Research & Therapy
  12. Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle
    Emma Coakley-Youngs, Susan A. Shorter, Medhavi Ranatunga, Simon Richardson, Giulia Getti, Marc L. Fivaz · 2022 · Biology Open
  13. Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression
    Chaodong Ding, Wei Zhou, Yuhan Shi, Shifang Shan, Yiting Yuan, Yuefang Zhang, Fei Li, Zilong Qiu · 2024 · Cell Reports
  14. Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of CHD8 heterozygous cerebral organoids
    Maider Astorkia, Yang Liu, Erika Pedrosa, Herbert M. Lachman, Deyou Zheng · 2024 · Heliyon
  15. Integrated microRNA–mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Autism
    Pritmohinder S. Gill, Harsh Dweep, Shannon Rose, Priyankara Wickramasinghe, Kanan K. Vyas, Sandra S. McCullough, Patricia A Porter-Gill, Richard E. Frye · 2022 · Journal of Personalized Medicine
  16. CRISPR-engineered genome editing for the next generation neurological disease modeling
    Weijun Feng, Hai‐Kun Liu, Daisuke Kawauchi · 2017 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  17. CRISPR tool modifies genes precisely by copying RNA into the genome
    Randall J. Platt · 2019 · Nature
  18. Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder
    Melina Matthiesen, Abdessattar Khlaifia, Carl Frank David Steininger, Maryam Dadabhoy, Unza Mumtaz, Maithé Arruda-Carvalho · 2023 · Molecular Brain
  19. Critical periods and Autism Spectrum Disorders, a role for sleep
    Elizabeth Medina, Sarah Peterson, Kaitlyn Ford, Kristan G. Singletary, Lucı́a Peixoto · 2022 · Neurobiology of Sleep and Circadian Rhythms
  20. The complex etiology of autism spectrum disorder due to missense mutations of CHD8
    Taichi Shiraishi, Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Tsuyoshi Miyakawa, Taisuke Mizoo, Akinobu Matsumoto, Atsushi Hijikata, Tsuyoshi Shirai, Kouta Mayanagi et al. · 2024 · Molecular Psychiatry
  21. Haploinsufficiency ofSyngap1in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice
    Laura M. Haetzel, Jillian Iafrati, Katherine R Cording, Mahmoud Farhan, Sasan D. Noveir, Gavin Rumbaugh, Helen S. Bateup · 2024 · Journal of Neuroscience
  22. SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in autism spectrum disorder model systems
    Francesca Di Leva, Michele Arnoldi, Stefania Santarelli, Mathieu Massonot, Marianne Victoria Lemée, Carlotta Bon, Miguel Pellegrini, Maria Elena Castellini, Giulia Zarantonello, Andrea Messina et al. · 2024 · Molecular Therapy
  23. Nervous system development and disease: A focus on trithorax related proteins and chromatin remodelers
    Amanda Moccia, Donna M. Martin · 2017 · Molecular and Cellular Neuroscience
  24. Chromodomain helicase DNA-binding proteins and neurodevelopmental disorders
    Heba Yasin, Farah Zahir · 2020 · Journal of Translational Genetics and Genomics
  25. Distinct genetic patterns of shared and unique genes across four neurodevelopmental disorders
    Yijia Zhang, Ruochen Wang, Zhenwei Liu, Shan Jiang, Li-Feng Du, Kairui Qiu, Fengxia Li, Qiongdan Wang, Jing Jin, Xiaomin Chen et al. · 2020 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
  26. Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors
    Soo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim · 2022 · Frontiers in Molecular Neuroscience
  27. Translating genetic and preclinical findings into autism therapies
    Maria H. Chahrour, Robin J. Kleiman, M. Chiara Manzini · 2017 · Dialogues in Clinical Neuroscience
  28. Identification of a transcriptional signature found in multiple models of ASD and related disorders
    Samuel Thudium, Katherine C. Palozola, Éloïse L'Her, Erica Korb · 2022 · Genome Research
  29. Age‐related behavioural and striatal dysfunctions in Shank3 ΔC/ΔC mouse model of autism spectrum disorder
    Mathieu Thabault, Valentine Turpin, Éric Balado, Cloé Fernandes‐Gomes, Anne-Lise Huot, Anne Cantereau, Pierre‐Olivier Fernagut, Mohamed Jaber, Laurie Galvan · 2023 · European Journal of Neuroscience
  30. Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologies
    Helen Forgham, Liwei Liu, Jiayuan Zhu, Ibrahim Javed, Weibo Cai, Ruirui Qiao, Thomas Paul Davis · 2023 · Coordination Chemistry Reviews
  31. De novo mutations in folate-related genes associated with common developmental disorders
    Tengfei Luo, Kuokuo Li, Zhengbao Ling, Guihu Zhao, Bin Li, Zheng Wang, Xiaomeng Wang, Ying Han, Lu Xia, Yi Zhang et al. · 2021 · Computational and Structural Biotechnology Journal
  32. Sex bias in autism: new insights from Chd8 mutant mice?
    Laura C. Andreae, M. Albert Basson · 2018 · Nature Neuroscience
  33. Enhancer-targeted CRISPR-A rescues haploinsufficiency and mutant phenotypes in organoid models of autism
    George T Chen, Gayatri Nair, Aubrey J. Osorio, Sandra M. Holley, Kimiya Ghassemzadeh, Yixuan Zhou, Jose Gonzalez, Jacqueline M. Martin, Congyi Lu, Neville E. Sanjana et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Cortical-cerebellar circuits changes in preschool ASD children by multimodal MRI
    Ting Yi, Changquan Ji, Weian Wei, Guangchung Wu, Ke Jin, Guihua Jiang · 2024 · Cerebral Cortex
  35. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
    Katherine R Cording, Emilie M Tu, Hongli Wang, Alexander H.C.W. Agopyan-Miu, Helen S. Bateup · 2025 · eLife
  36. Duplication of the autism-related gene Chd8 leads to behavioral hyperactivity and neurodevelopmental defects in mice
    Atsuki Kawamura, Kazuki Fujii, Kota Tamada, Yoshifumi Abe, Kenta Nitahara, Tomoya Iwasaki, Sho Yagishita, Kenji F. Tanaka, Toru Takumi, Keizo Takao et al. · 2025 · Nature Communications
  37. Autism Spectrum Disorder: From Experimental Models to Probiotic Application with a Special Focus on Lactiplantibacillus plantarum
    Giusi Sabatini, Ilenia Boccadoro, Roberta Prete, Natalia Battista, Aldo Corsetti · 2025 · Nutrients
  38. Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development
    Kristina Yim, Marybeth Baumgartner, Martina Krenzer, María F. Rosales Larios, Guillermina Hill-Terán, Timothy Nottoli, Rebecca Muhle, James P. Noonan · 2025 · Cell Genomics
  39. Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons
    Roberto De Gregorio, Galadu Subah, Jennifer C Chan, Luisa Speranza, Xiaolei Zhang, Aarthi Ramakrishnan, Li Shen, Ian S. Maze, Patric K. Stanton, Ji Ying Sze · 2022 · Development
  40. Over-expressed LOC101927196 suppressed oxidative stress levels and neuron cell proliferation in a rat model of autism through disrupting the Wnt signaling pathway by targeting FZD3
    Wanxia Yao, Junting Huang, Hongling He · 2019 · Cellular Signalling
  41. In vivo targeted DamID identifies CHD8 genomic targets in fetal mouse brain
    A. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord · 2021 · iScience
  42. Spatial and Temporal Gene Function Studies in Rodents: Towards Gene-Based Therapies for Autism Spectrum Disorder
    Iris W. Riemersma, Robbert Havekes, Martien J. Kas · 2021 · Genes
  43. Neuroimmune and behavioral changes elicited by maternal immune activation in mice are ameliorated by early postnatal immune stimulation
    Lourdes K. Davis, Louise Madeleine Ince, Sriya Gullapalli, Laura K. Fonken · 2025 · Brain Behavior and Immunity
  44. Mechanisms of brain overgrowth in autism spectrum disorder with macrocephaly
    Laura Currey, Tracey J. Harvey, Alexandra Pelenyi, Michael Piper, Stefan Thor · 2025 · Frontiers in Neuroscience
  45. Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development
    Noémie Adès, Lamia Bouslama‐Oueghlani · 2026 · Molecular Psychiatry
  46. Neuroepigenetic Editing
    Peter J. Hamilton, Carissa J. Lim, Eric J. Nestler, Elizabeth A. Heller · 2024 · Methods in molecular biology
  47. Natural SINEUP RNAs in Autism Spectrum Disorders: RAB11B-AS1 Dysregulation in a Neuronal CHD8 Suppression Model Leads to RAB11B Protein Increase
    Giulia Zarantonello, Michele Arnoldi, Michele Filosi, Toma Tebaldi, Giovanni Spirito, Anna Barbieri, Stefano Gustincich, Remo Sanges, Enrico Domenici, Francesca Di Leva et al. · 2021 · Frontiers in Genetics
  48. Impact of KDM6B mosaic brain knockout on synaptic function and behavior
    Bastián Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo C. Meza, Nicolás Merino-Véliz, Gino Nardocci, Lorena Varela‐Nallar, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos · 2024 · Scientific Reports
  49. Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex
    Chelsea S. Sullivan, Vishwa Mohan, Paul B. Manis, Sheryl S. Moy, Young Kinh-Nhue Truong, Bryce W. Duncan, Patricia F. Maness · 2020 · Cerebral Cortex
  50. Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes
    Soo Yeon Lee, Hanseul Kweon, Hyojin Kang, Eunjoon Kim · 2023 · Frontiers in Molecular Neuroscience
  51. Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome
    Brigitta B. Gundersen, William T. O’Brien, Melanie D. Schaffler, Maria N. Schultz, Tatsuya Tsukahara, Sandra Martín Lorenzo, Valérie Nalesso, Alice Luo Clayton, Ted G. Abel, Jacqueline N. Crawley et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in mice
    Julie Le Merrer, Bérangère Detraux, Jorge Gandía, A. De Groote, Mathieu Fonteneau, Alban de Kerchove d’Exaerde, Jérôme A. J. Becker · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  53. CHD8 adulthood microglial knockdown in C57BL6 mice induces behavioral, morphological, and transcriptional changes in a sex-dependent manner
    Orly Weissberg, Ram Harari, Chizim Dogun, Dmitriy Getselter, Evan Elliott · 2025 · Translational Psychiatry
  54. A Blueprint for Translational Precision Medicine in Autism Spectrum Disorder and Related Neurogenetic Syndromes
    Robyn Pauline Thom, Tracy L. Warren, Suha Khan, Rebecca Muhle, Paul P. Wang, Kristen Brennand, Nicole R. Zürcher, Jeremy M. Veenstra-VanderWeele, Ellen J. Hoffman · 2025 · Journal of Child and Adolescent Psychopharmacology
  55. Neural Network Excitation/Inhibition: A Key to Empathy and Empathy Impairment
    Yuanhong Tang, Chunjian Wang, Qingquan Li, Gang Liu, Da Feng Song, Zhenzhen Quan, Yan Yan, Hong Qing · 2024 · The Neuroscientist
  56. CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis
    Ipsita Chatterjee, Dimitry Getselter, Nasreen Ghaneem, Shai Bel, Evan Elliott · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in early adolescent male but not female mice
    Juliana B. Chase, Jing‐Jing Li, Wan Chen Lin, Lung-Hao Tai, Fernanda Castro, Anne Gabrielle Eva Collins, Linda Wilbrecht · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Gene–Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility
    Eduardo Quiñones‐Medina, Felipe Galleguillos, Valentina Parra, Gloria Arriagada, Fernando J. Bustos · 2026 · Autism Research
  59. Diagnosis of autism spectrum disorder—prediction and analysis of enhanced classification model based on machine learning
    M.S. Sankari, A. Kannammal · 2025 · Elsevier eBooks
  60. Neural connections and molecular mechanisms underlying motor skill deficits in genetic models of autism spectrum disorders
    Jingwen Duan, Deyang Zeng, Tong Wu, Zhenzhao Luo, Geng Jingwen, Wei Tan, Yan Zeng · 2025 · Progress in Neurobiology
  61. Animal models of autism
    Elizabeth L. Berg, Jill L. Silverman · 2022 · Elsevier eBooks
  62. The Deficiency of the ASD-Related Gene CHD8 Disrupts Behavioral Patterns and Inhibits Hippocampal Neurogenesis in Mice
    Xiaojie Niu, Feifei Huang, Haizhen Lyu, Jiao Liu, Xinwei Zhang, Jiang Bian, Zhijie Gao, Binyu Liu · 2024 · Journal of Molecular Neuroscience
  63. Small SNPs, Big Effects: A Review of Single Nucleotide Variations and Polymorphisms in Key Genes Associated With Autism Spectrum Disorder
    Sriharikrishnaa Srinath, Akanksha A. Kalal, Preethika Anand, Satyajit Mohapatra, Prabahan Chakraborty · 2025 · International Journal of Developmental Neuroscience
  64. Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation
    Oakleigh M. Folkes, Meaghan Donahue, Sung Eun Wang, Paola N. Negrón-Moreno, Nicole Xinyen Oo, Sheng-Nan Qiao, Xiaoming Wang, Yong‐hui Jiang · 2025 · Communications Biology
  65. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
    Katherine R Cording, Emilie M Tu, Hongli Wang, Alexander H.C.W. Agopyan-Miu, Helen S. Bateup · 2024 · eLife
  66. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
    Katherine R Cording, Emilie M Tu, Hongli Wang, Alexander H.C.W. Agopyan-Miu, Helen S. Bateup · 2024 · eLife
  67. Morphological study of embryonic Chd8+/− mouse brains using light-sheet microscopy
    Harold Fernando Gómez, Leonie Hodel, Odyssé Michos, Dagmar Iber · 2021 · BMC Research Notes
  68. The human chd8 gene is transcribed from two distant upstream promoters
    Gary R. Kunkel, Hannah G. Lisciandro, Hannah L. Winter · 2020 · Biochemical and Biophysical Research Communications
  69. Rise of the Chromodomain Helicase DNA‐Binding (CHD) Chromatin Remodelling Machines
    Andrej Alendar · 2023 · Wiley eBooks
  70. Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signalling
    Leticia Pérez‐Sisqués, S. Bhatt, Angela Caruso, Mohi U. Ahmed, Talia E. Gileadi, Shoshana Spring, Eleanor Hendy, Joyce Taylor‐Papadimitriou, Diana Cash, Nicholas E. Clifton et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Chd8 haploinsufficiency leads to molecular layer heterotopias and age-dependent cortical expansion
    Felix A. Kyere, Ian Curtin, Ziquan Wei, César P. Canales, Nicolas Seban, Lei Xing, Preslava P Todorova, Leticia Pérez-Sisqués, Maya Yilan Yin, Tao Wen et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  72. Kismet/CHD7/CHD8 and Amyloid Precursor Protein-like Regulate Synaptic Levels of Rab11 at the Drosophila Neuromuscular Junction
    Emily L. Hendricks, Nicole Linskey, Ireland R. Smith, Faith L. W. Liebl · 2024 · International Journal of Molecular Sciences
  73. Sequencing perturbed cortex development
    Barbara Treutlein, J. Gray Camp · 2020 · Science
  74. Functional genomics of psychiatric disease risk using genome engineering
    Meilín Fernández García, Samuel K. Powell, Elizabeth A. LaMarca, Michael B. Fernando, Sophie Cohen, Gang Fang, Schahram Akbarian, Kristen Brennand · 2021 · Elsevier eBooks
  75. Altered neocortical gene expression, brain overgrowth and functional over-connectivity in Chd8 haploinsufficient mice
    Philipp Suetterlin, Shaun Hurley, Conor Mohan, Kimberley L. H. Riegman, Marco Pagani, Angela Caruso, Jacob Ellegood, Alberto Galbusera, Ivan Crespo-Enriquez, Caterina Michetti et al. · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Neurodevelopmental disease genes implicated by de novo mutation and CNV morbidity
    Bradley P. Coe, Holly A.F. Stessman, Arvis Sulovari, Madeleine R. Geisheker, Fereydoun Hormozdiari, Evan E. Eichler · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  77. Non-monotonic regulation of gene expression, neural progenitor fate and brain growth by the chromatin remodeller CHD8
    Shaun Hurley, Conor Mohan, Philipp Suetterlin, Jacob Ellegood, Fabrizio Rudari, Jason P. Lerch, Cathy Fernandes, M. Albert Basson · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  78. CHD8 regulates the balance between proliferation and differentiation of human iPSCs in neural development
    Wenzhong Liu, Weilai Dong, Ellen J. Hoffman, Thomas V. Fernandez, Abha R. Gupta · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning
    Katelyn N. Benthall, Katherine R Cording, Alexander H.C.W. Agopyan-Miu, Emily Y. Chen, Helen S. Bateup · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  80. Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamID
    A. Ayanna Wade, Jelle van den Ameele, Seth W. Cheetham, Rebecca Yakob, Andrea H. Brand, Alex S. Nord · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  81. Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice
    César P. Canales, Stephanie A. Lozano, Nicholas Alonzo Frost, Karol Cichewicz, Wellington Z. Amaral, Nicolas Seban, Ethan Fenton, A. Ayanna Wade, Nickolas Chu, Emily M. Smith et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  82. Gene regulatory networks controlling neuronal development
    Jason T. Lambert, J.L. Haigh, Alex S. Nord · 2020 · Elsevier eBooks
  83. Etiologies underlying sex bias in autism spectrum disorder: a narrative review of preclinical rodent models
    Taeyoung Lee, Eunha Kim · 2024 · Ewha Medical Journal
  84. Genetic etiology and neurobiological mechanisms of autism spectrum disorders
    Jing ZHANG, XiangBin JIA, Kun Xia, Hui Guo, Jia‐Da Li · 2024 · Scientia Sinica Vitae
  85. Chd8 Deficiency in Zebrafish Causes Autism-Like Behavioral Deficits
    Han-Tsing Wang, Xiao-Tong Fu, Ye-Fan Wang, Lingyan Liu, Zhi-Zhi Liu, Hong A. Xu · 2025 · Journal of Integrative Neuroscience
  86. CHD8 dysregulation in neurodevelopment: Emerging insights into autism pathophysiology
    Dhrita Chatterjee, Kousik Maparu · 2026 · International Journal of Biological Macromolecules
  87. Personalized Medicine in Autism Spectrum Disorder: Integrating Epigenomics, Microbiome Research and Early Diagnostics
    Amr Ali Mohamed Abdelgawwad El‐Sehrawy, Omar I. Aljumaili, Ulug'bek Axmedov, Mohamad Ahmad Saleem Khasawneh, Mansuor A. Alanazi, Aseel Smerat, Tina Saeed Basunduwah · 2026 · International Journal of Developmental Neuroscience
  88. Homozygous CHD8 mutation intensifies ASD phenotypes and attenuates sex differences
    Jinkyeong Kim, Seungjoon Lee, Eunkyu Hwang, Hwajin Jung, Chanhee Lee, Sang‐Han Choi, Sooyeon Lee, Seongbin Kim, Heera Moon, Jisoo Kim et al. · 2026 · Molecular Psychiatry
  89. Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency
    Leticia Pérez‐Sisqués, Shail Ratna Bhatt, Angela Caruso, Josephine Louise Robb, Alex P. A. Donovan, Rosemary A. Bamford, Alejo Torres-Cano, Shoshana Spring, Eleanor Hendy, Talia E. Gileadi et al. · 2026 · Science Advances
  90. Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice
    Kenta Nitahara, Atsuki Kawamura, Ayumu Tashiro, Tomoya Iwasaki, Shin-ichi Horike, Jumpei Terakawa, Takiko Daikoku, Koichi Higashi, Ken Kurokawa, Kiyoko Kato et al. · 2026 · Nature Communications
  91. Chd8 haploinsufficiency impacts rearing experience in C57BL/6 mice
    Manal Tabbaa, Pat R. Levitt · 2024 · Genes Brain & Behavior
  92. Increased cortical volume without increased neuron number in heterozygous Chd8 mutant mouse cortex
    César P. Canales, Samuel Frank, Jeffrey Bennett, Paris Beauregard, Pierre Lavenex, David G. Amaral, Alex S. Nord · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  93. A dual-activity Topoisomerase Complex Regulates both Transcription and Translation
    Shuaikun Su, Yutong Xue, Alexei A. Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L. Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De et al. · 2021 · Research Square
  94. A dual-activity topoisomerase complex regulates translation and abundance of mRNAs important for psychiatric disorders
    Shuaikun Su, Yutong Xue, Alexei A. Sharov, Yongqing Zhang, Seung kyu Lee, Jennifer L. Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De et al. · 2022 · Research Square
  95. Srcap Haploinsufficiency Induced Autistic-Like Behaviors in Mice through Disruption of Satb2 Expression
    Chaodong Ding, Yuhan Shi, Shifang Shan, Yiting Yuan, Yuefang Zhang, Zilong Qiu · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  96. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility
    Katherine R Cording, Emilie M Tu, Hongli Wang, Alexander H.C.W. Agopyan-Miu, Helen S. Bateup · 2025 · eLife
  97. CHD8 Regulates Cellular Homeostasis and Neuronal Function Genes Across Multiple Models of CHD8 Haploinsufficiency
    A. Ayanna Wade, Kenneth J. Lim, Rinaldo Catta-Preta, Alex S. Nord · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Future perspectives: autism, a disorder of biometal imbalance?
    Andreas Martin Grabrucker · 2020 · Elsevier eBooks
  99. Transcriptomic Analysis in the Striatum Reveals an Involvement of Nurr1 in Social Behavior of Prenatally Valproic Acid-Exposed Mice
    Hyun-Ju Kim, Eun-Jeong Yang, Han-Byeol Kim, Eun hwa Jo, Ran‐Sook Woo, Seonghan Kim, Kim Hye-Sun · 2021 · Research Square
  100. Epigenetic regulation of odontogenic stem cells and their application in pulp and periodontal regeneration
    Zhuoxuan Wu, Xiayi Wang, Yuyang Chen, Shiyu Jia, Mian Wan · 2022 · Research Square