PHGDH defines a metabolic subtype in lung adenocarcinomas with poor prognosis

Zhang, Boxi, Zheng, Adi, Hydbring, Per, Ambroise, Gorbatchev, Ouchida, Amanda Tomie, Goiny, Michel, Vakifahmetoglu-Norberg, Helin, Norberg, Erik·2017·Cell Reports

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  13. Upregulation of HOXA13 as a potential tumorigenesis and progression promoter of LUSC based on qRT-PCR and bioinformatics.
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  16. Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine
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  17. Integration of Transcriptomics and Metabolomics Reveals Metabolism Dysregulation in HIV-1-Infected Macrophages
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  23. ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis
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  24. HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration
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  28. PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer
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  38. XPR1 downregulation inhibits hepatocellular carcinoma progression by suppressing serine metabolism
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  39. Cysteine Metabolism in the Control of Oxidative Stress in Cancer, Focusing on Carbon and Sulfur Metabolism
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  40. Epigenetics and One-Carbon Metabolism in Cancer: Mechanisms and Therapeutic Implications
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  41. Construction and Validation of a CNV-Driven Ferroptosis-Related Gene Signature for Predicting the Prognosis of Lung Adenocarcinoma
    Yanqing Wang, Yi Zhao, Yong Hui Li, Zemin Luo, Hongzhu Chen · 2022 · Journal of Sensors · Retracted
  42. Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis
    Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino Del Ferraro, Diane S. Kang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Translational and HIF11-Dependent Metabolic Reprograming Underpin Oncometabolome Plasticity and Synergy Between Oncogenic Kinase Inhibitors and Biguanides
    Laura Hulea, Simon‐Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Young Kyuen Im, Shannon McLaughlan, Ola Segnestam Larsson, Michael Ohh, Tiago Ferreira et al. · 2018 · SSRN Electronic Journal
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  45. Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression.
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  47. Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis.
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  49. Identification of Novel Diagnostic Markers for Malignant Pleural Mesothelioma Using a Reverse Translational Approach Based on a Rare Synchronous Tumor
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  50. One-carbon metabolism in lung cancer
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  55. MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability
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  58. Additional file 4 of Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients
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  63. Additional file 2 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells
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  68. Additional file 5 of Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients
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  69. Additional file 1 of Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells
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  81. BindingDB Entry 50019189: Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy.
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  82. BindingDB Entry 50018393: A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism.
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  83. BindingDB Entry 50008414: Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor
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