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Linking Serine/Glycine Metabolism to Radiotherapy Resistance

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PHGDH as a mechanism for resistance in metabolically-driven cancers

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Metabolomics of lung cancer: Analytical platforms and their applications

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The deubiquitinase JOSD2 is a positive regulator of glucose metabolism

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Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

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Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway

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PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1

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Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

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Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

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Metabolism in tumour-associated macrophages: a<i>quid pro quo</i>with the tumour microenvironment

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N6-Methyladenosine modification activates the serine synthesis pathway to mediate therapeutic resistance in liver cancer

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Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis

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Pharmacological inhibition of serine synthesis enhances temozolomide efficacy by decreasing O6-methylguanine DNA methyltransferase (MGMT) expression and reactive oxygen species (ROS)-mediated DNA damage in glioblastoma

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Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes

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High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer

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Target enzymes in serine‐glycine‐one‐carbon metabolic pathway for cancer therapy

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Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

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One carbon metabolism in human lung cancer

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Serine–glycine-one-carbon metabolism: vulnerabilities in MYCN-amplified neuroblastoma

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Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

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Systemic evolutionary chemical space exploration for drug discovery

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Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients

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PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells

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The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment

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miR-126-5p targets Malate Dehydrogenase 1 in non-small cell lung carcinomas

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ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis

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ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC

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Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

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The role of deubiquitinating enzymes in gastric cancer (Review)

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Systematic analysis reveals a functional role for STAMBPL1 in the epithelial–mesenchymal transition process across multiple carcinomas

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Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance

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Mitochondrial Plasticity and Glucose Metabolic Alterations in Human Cancer under Oxidative Stress—From Viewpoints of Chronic Inflammation and Neutrophil Extracellular Traps (NETs)

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Transcriptional Activation of Chac1 and Other Atf4-Target Genes Induced by Extracellular l-Serine Depletion is negated with Glycine Consumption in Hepa1-6 Hepatocarcinoma Cells

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Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity

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Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia

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Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells

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Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy

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Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis

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Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade

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JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression

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Drugging cancer metabolism: Expectations vs. reality

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Metabolic reprogramming and therapeutic targeting in non-small cell lung cancer: emerging insights beyond the Warburg effect

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Multi‐kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin‐related protein 1

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PHGDH Inhibitor CBR‐5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β‐Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib

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Prognostic significance of phosphoglycerate dehydrogenase in breast cancer

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JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes

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Joint Transcriptomic Analysis of Lung Cancer and Other Lung Diseases

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Competition between p53 and YY1 determines PHGDH expression and malignancy in bladder cancer

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Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma

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The enzymes of serine synthesis pathway in cancer metastasis

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Metabolism-Related Gene Expression in Circulating Tumor Cells from Patients with Early Stage Non-Small Cell Lung Cancer

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Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies

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Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms

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PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability

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Moonlighting functions of phosphoglycerate dehydrogenase in cancer

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Glucose and fatty acid metabolism involved in the protective effect of metformin against ulipristal-induced endometrial changes in rats

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Glucose metabolism in B cell malignancies: a focus on glycolysis branching pathways

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Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells

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Cancer's sweet tooth for serine

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3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment

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Metabolic pathway signatures define prognostic subtypes of lung adenocarcinoma

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PHGDH as a mechanism for resistance in metabolically-driven cancers

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Cancer metabolism: Addicted to serine.

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