Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity
Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T. +17 more·2018·Cell Reports
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- Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligenceBryce K. Allen, Meghana M. Kulkarni, Brian T. Chamberlain, Timothy Dwight, Cheryl M. Koh, Ramya Samant, Finith E. Jernigan, Jamie Rice, Dazhi Tan, Stella Li et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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- Listeria monocytogenes Cancer Vaccines: Bridging Innate and Adaptive ImmunityZachary T. Morrow, Zachary M. Powers, John‐Demian Sauer · 2019 · Current Clinical Microbiology Reports
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- Amphiphilic Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING AgonistsDinh Chuong Nguyen, Daniel Shae, Hayden M. Pagendarm, Kyle W. Becker, Mohamed Wehbe, Kameron V. Kilchrist, Lucinda E. Pastora, Christian R. Palmer, Pedro Seber, Plamen P. Christov et al. · 2020 · Advanced Healthcare Materials
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- GAS-STING: a classical DNA recognition pathways to tumor therapyXinrui Wang, Meijia Lin, Liping Zhu, Zhoujie Ye · 2023 · Frontiers in Immunology
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- Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy ModelsAndreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, Sarah Stevens, Antitsa D. Stoycheva, Vivek K. Rajwanshi, Caroline T. Williams, Jérôme Deval et al. · 2023 · International Journal of Molecular Sciences
- Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effectsQiuli Xu, Xin Hua, Bingbing Li, Bei Jiang, Jiajia Jin, Ranpu Wu, Yanli Gu, Hao Xu, Qinpei Cheng, Suhua Zhu et al. · 2025 · Cell Communication and Signaling
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- Computational design of constitutively active cGASQuinton M. Dowling, Hannah E. Volkman, Elizabeth E. Gray, Sergey Ovchinnikov, Stephanie Cambier, Asim K. Bera, Banumathi Sankaran, Max R. Johnson, Matthew J. Bick, Alex Kang et al. · 2023 · Nature Structural & Molecular Biology
- Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonistRuochen Zang, Liang Xue, Meifang Zhang, Xiaoyue Peng, Xionghao Li, Kaixin Du, Chuanqin Shi, Yuqian Liu, Yuxi Lin, Wenwei Han et al. · 2023 · European Journal of Medicinal Chemistry
- Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING PathwayYu Jiang, Xiyuan Li, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie, Sheng Yang · 2023 · Research
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- Stimulating STING for cancer therapy: Taking the extracellular routeLingyin Li · 2024 · Cell chemical biology
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- Inhibition of CPT1A activates the cGAS/STING pathway to enhance neutrophil-mediated tumor abrogation in triple-negative breast cancerChenglong Li, Tingfang Gao, Qiuling Zhao, Zhi Li, Zhidong Wang, Shuaishuai Ding, Mengsi Zhang, Yan Qin, Xinwen Xue, Xiao Zhang et al. · 2025 · Cancer Letters
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- Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment contextJustyna Czapla, Alina Drzyzga, Sybilla Matuszczak, Tomasz Cichoń, Marek Rusin, Magdalena Jarosz–Biej, Ewelina Pilny, Ryszard Smolarczyk · 2023 · Frontiers in Oncology
- The Proper Administration Sequence of Radiotherapy and Anti-Vascular Agent—DMXAA Is Essential to Inhibit the Growth of Melanoma TumorsAlina Drzyzga, Tomasz Cichoń, Justyna Czapla, Magdalena Jarosz–Biej, Ewelina Pilny, Sybilla Matuszczak, Piotr Wojcieszek, Zbigniew Urbaś, Ryszard Smolarczyk · 2021 · Cancers
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- AND logic nanoparticle for precision immunotherapy of metastatic cancersShuyue Ye, Shuang Chen, Vijay S. Basava, Katy Torres, Yangyang Zhao, Gang Huang, Mingyi Chen, Jinming Gao · 2026 · Nature Nanotechnology
- High levels of tumor cell-intrinsic STING signaling are associated with increased infiltration of CD8+ T cells in dMMR/MSI-H gastric cancerRyo Kanoda, Shotaro Nakajima, Satoshi Fukai, Motonobu Saito, Katsuharu Saito, Hiroya Suzuki, Tomohiro Kikuchi, Azuma Nirei, Hirokazu Okayama, Kosaku Mimura et al. · 2024 · Scientific Reports
- EXOTLR1/2-STING: A Dual-Mechanism Stimulator of Interferon Genes Activator for Cancer ImmunotherapyTianyang Wang, Hong‐Guo Hu, Lang Zhao, Shao‐Hua Zhuo, Jingyun Su, Geng-Hui Feng, Yanmei Li · 2025 · ACS Nano
- Nanomedicinal Delivery of Stimulator Of Interferon Genes Agonists: Recent Advances in Virus VaccinationSaborni Chattopadhyay, Che‐Ming Jack Hu · 2020 · Nanomedicine
- STING Signaling and Skin CancersSayaka Sato, Yu Sawada, Motonobu Nakamura · 2021 · Cancers
- Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosisWangsheng Ji, Lianfei Zhang, Chengxin Ma, Xiaoyu Xu, Shuai Li, Huan Xia, Weihong Zhou, Xinqi Liu · 2023 · Cell Reports
- Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD miceSatoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L. Graham, Balasubramanian Krishnamurthy, Evan G. Pappas, Chun-Ting J. Kwong et al. · 2021 · Diabetologia
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- Heterogeneity of the tumor immune microenvironment and clinical interventionsZheng Jin, Qin Zhou, Jianan Cheng, Qingzhu Jia, Bo Zhu · 2023 · Frontiers of Medicine
- Combination of STING agonist with anti-vascular RGD-(KLAKLAK)2 peptide as a novel anti-tumor therapyJustyna Czapla, Alina Drzyzga, Joanna Ciepła, Sybilla Matuszczak, Magdalena Jarosz–Biej, Ewelina Pilny, Tomasz Cichoń, Ryszard Smolarczyk · 2024 · Cancer Immunology Immunotherapy
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- What role of the cGAS-STING pathway plays in chronic pain?Jingxiang Wu, Xin Li, Xiaoxuan Zhang, Wei Wang, Xingji You · 2022 · Frontiers in Molecular Neuroscience
- Distinct oligomeric assemblies of STING induced by non-nucleotide agonistsAnant Gharpure, Ariana Sulpizio, Johannes R. Loeffler, Monica L. Fernández‐Quintero, Andy S. Tran, Luke L. Lairson, Andrew B. Ward · 2025 · Nature Communications
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- Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analysesThomas Pulliam, Saumya Jani, Peter H. Goff, Rashmi Bhakuni, Shira Tabachnick‐Cherny, Kimberly S. Smythe, Brandon W. Seaton, Lisa May Ling Tachiki, Rima M. Kulikauskas, Candice D. Church et al. · 2024 · Journal for ImmunoTherapy of Cancer
- Coimmunomodulation of tumor and tumor-draining lymph nodes during in situ vaccination promotes antitumor immunityMoonkyoung Jeong, Heegon Kim, Junyong Yoon, Dong‐Hyun Kim, Ji‐Ho Park · 2022 · JCI Insight
- Bioinspired nucleic acid structures for immune modulationCameron Louttit, Kyong Soo Park, James Jaehyun Moon · 2019 · Biomaterials
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