Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T. +17 more·2018·Cell Reports
DOI 10.1016/j.celrep.2018.11.047

Cited by (457)

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  9. Targeting STING-ATM axis overcomes radiotherapy-induced immune suppression and restores anti-tumor immunity in nasopharyngeal carcinoma
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  10. Systemic STING agonist therapy drives expression of interferon stimulated genes and downstream production of cytokines in dogs with solid tumors
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  11. Additional file 1 of Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
    Xie, Wei, Zhang, Leiying, Junjing Shen, Fengdi Lai, Wenling Han, Liu, Xiaoyan · 2024 · Figshare
  12. Additional file 2 of Knockdown of CENPM activates cGAS-STING pathway to inhibit ovarian cancer by promoting pyroptosis
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  13. Additional file 2 of Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia
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  14. Marine Bromophenol Derivatives as a Novel Class of Potent Small-Molecule STING Agonists
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  15. Roles and clinical translational prospects of TMEM proteins in the tumor immune microenvironment
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  16. Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9
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  17. Assembled DNA Nanostructure to Precisely Induced cGAS‐STING Activation for Cancer Immunotherapy
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  18. Targeting STING activation in antigen-presenting cells via natural polysaccharide-engineered vesicles for antitumor immunotherapy
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  19. Etude du rôle de STING dans la biologie des lymphocytes T CD4 : application en immunothérapie anticancéreuse
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  20. Local Anti-CTLA4 Cancer Immunotherapy From Bench to Bedside
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  26. The Emerging Role of Nanocarrier-Based Delivery Systems for cGAS-STING Activation in Cancer Immunotherapy
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  27. Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling
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  46. Nanoengineered STING agonists for cancer therapy: toward immunodynamic control
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  47. Reprogramming the tumor microenvironment from within: intratumoral immunoadjuvants in cancer immunotherapy
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  48. BindingDB Entry 50018856: Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.
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  49. BindingDB Entry 50022447: Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.
    BindingDB · 2025 · UC San Diego
  50. BindingDB Entry 50018006: Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.
    BindingDB · 2023 · UC San Diego
  51. BindingDB Entry 50023761: Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity.
    BindingDB · 2026 · UC San Diego
  52. BindingDB Entry 50022354: Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
    BindingDB · 2025 · UC San Diego
  53. BindingDB Entry 50019243: Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
    BindingDB · 2024 · UC San Diego
  54. BindingDB Entry 50007632: Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective.
    BindingDB · 2021 · UC San Diego
  55. BindingDB Entry 50015070: Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
    BindingDB · 2023 · UC San Diego
  56. BindingDB Entry 50019508: Structure-activity relationship study of amidobenzimidazole derivatives as stimulator of interferon genes (STING) agonists.
    BindingDB · 2024 · UC San Diego
  57. BindingDB Entry 50017730: Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
    BindingDB · 2023 · UC San Diego