The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Dissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell Transcriptomics
Open accessAbstract
Sex determination is a unique process that allows the study of multipotent progenitors and their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary. Using time series single-cell RNA sequencing (scRNA-seq) on ovarian Nr5a1-GFP + somatic cells during sex determination, we identified a single population of early progenitors giving rise to both pre-granulosa cells and potential steroidogenic precursor cells. By comparing time series single-cell RNA sequencing of XX and XY somatic cells, we provide evidence that gonadal supporting cells are specified from these early progenitors by a non-sex-specific transcriptomic program before pre-granulosa and Sertoli cells acquire their sex-specific identity. In XX and XY steroidogenic precursors, similar transcriptomic profiles underlie the acquisition of cell fate but with XX cells exhibiting a relative delay. Our data provide an important resource, at single-cell resolution, for further interrogation of the molecular and cellular basis of mammalian sex determination.
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Cites
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Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage
Val, P., Martinez-Barbera, J.-P., & Swain, A. (2007) · Development · doi:10.1242/dev.004390 · Cited by 150
Cited by
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Niu, W., & Spradling, A. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005570117 · Cited by 267
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Lindeman, R. E., Murphy, M. W., Agrimson, K. S., Gewiss, R. L., Bardwell, V. J., Gearhart, M. D., & Zarkower, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab448 · Cited by 66
Metadata
- Authors
- Stévant, I., Kühne, F., Greenfield, A., Chaboissier, M.-C., Dermitzakis, E. T., & Nef, S.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 26
- Issue
- 12
- Pages
- 3272-3283.e3
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2924322433
- Cited by
- 185
- References
- 4
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- gold
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