Microglia Heterogeneity in the Single-Cell Era

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Items 301–400 of 793

1. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia
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2. CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models
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3. Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
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4. Life without microglia
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5. Autophagy Pathways in CNS Myeloid Cell Immune Functions
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6. Transcriptome of microglia reveals a species‐specific expression profile in bovines with conserved and new signature genes
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7. Microglial- neuronal crosstalk in chronic viral infection through mTOR, SPP1/OPN and inflammasome pathway signaling
   Catalina Argandona Lopez, Amanda M Brown · 2024 · Frontiers in Immunology
8. Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): A role for microglia
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9. Blockade of kappa-opioid receptors amplifies microglia-mediated inflammatory responses
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10. Quantitative modeling of regular retinal microglia distribution
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11. MICROGLIA AND INFILTRATING T-CELLS ADOPT LONG-TERM, AGE-SPECIFIC, TRANSCRIPTIONAL CHANGES AFTER TRAUMATIC BRAIN INJURY IN MICE
    Zhangying Chen, Mecca B.A.R. Islam, Kacie P. Ford, Guangyuan Zhao, Shang-Yang Chen, Yidan Wang, Booker T. Davis, Alexios‐Fotios A. Mentis, Steven J. Schwulst · 2022 · Shock
12. Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases
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13. A CRISPRi/a platform in iPSC-derived microglia uncovers regulators of disease states
    Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Y. Hong, Giovanni Aviles, Claire Dudley Clelland, Lihong Zhan et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
14. Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
    Huang, August Yue, Zhou, Zinan, Talukdar, Maya, Enyenihi, Liz, Miller, Michael B., Chhouk, Brian, Rosen, Ila, Zheng, Mengyue, Zhou, Minye, Yang, Averill et al. · 2026 · Cell
15. Neuron–microglia interactions modulating neuropathic pain
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16. Amyloid β-Induced Inflammarafts in Alzheimer’s Disease
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17. Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia
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18. Single-Cell RNA Sequencing Reveals Microglial Heterogeneity and Functional States After Cerebral Ischemia-Reperfusion Injury
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19. Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol
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20. Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models
    N. Aghaizu, Sarah Jolly, Satinder K. Samra, B. Kalmar, K. Craessaerts, L. Greensmith, P. Salinas, B. de Strooper, P. Whiting · 2023 · eNeuro
21. Distinct spatiotemporal features of microglia and monocyte‐derived macrophages in glioma
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22. Electrophysiological Activity of Primary Cortical Neuron-Glia Mixed Cultures
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23. The Vicious Cycle of Melanoma-Microglia Crosstalk: Inter-Melanoma Variations in the Brain-Metastasis-Promoting IL-6/JAK/STAT3 Signaling Pathway
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24. Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases
    Ziping He, Qianqian Chen, Kaiyu Wang, Jiang Lin, Yilin Peng, Jinlong Zhang, Xi-Sheng Yan, Yan Jie · 2024 · European Journal of Neuroscience
25. Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity
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26. Microglia in physiological conditions and the importance of understanding their homeostatic functions in the arcuate nucleus
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27. Novel protocol for the isolation of highly purified neonatal murine microglia and astrocytes
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28. Characterization of Ex Vivo and In Vitro Wnt Transcriptome Induced by Spinal Cord Injury in Rat Microglial Cells
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29. Traumatic Brain Injury Induces Microglial and Caspase3 Activation in the Retina
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30. Retinal degenerative diseases: Complement system-microglia crosstalk
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31. Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice
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32. Sex-Specific Microglial Responses to Glucocerebrosidase Inhibition: Relevance to GBA1-Linked Parkinson’s Disease
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33. Mesenchymal Stem Cell-Derived Neural Progenitors Attenuate Proinflammatory Microglial Activation Via Paracrine Mechanisms
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34. ROLE OF MICROGLIA IN SEPSIS-ASSOCIATED ENCEPHALOPATHY PATHOGENESIS: AN UPDATE
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35. Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
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36. Post‐GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3
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37. Time- and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome
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38. Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism
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39. CD11c ‐Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells
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40. Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies
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41. Phagocytic microglia in development: Are they what they eat?
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42. Neuroglia — development and role in physiological and pathophysiological processes
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43. Microglia form satellites with different neuronal subtypes in the adult murine central nervous system
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44. POST-INJURY FECAL MICROBIOME TRANSPLANT DECREASES LESION SIZE AND NEUROINFLAMMATION IN TRAUMATIC BRAIN INJURY
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45. Cannabinoids, Inner Ear, Hearing, and Tinnitus: A Neuroimmunological Perspective
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46. Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis
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47. Nimodipine Exerts Time-Dependent Neuroprotective Effect after Excitotoxical Damage in Organotypic Slice Cultures
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48. Histamine and Microglia
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49. Advanced Therapies for Traumatic Central Nervous System Injury: Delivery Strategy Reinforced Efficient Microglial Manipulation
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50. Chronic Neuroinflammation and Cognitive Decline in Patients with Cardiac Disease: Evidence, Relevance, and Therapeutic Implications
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51. Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices
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52. Sex differences in the microglial response to stress and chronic alcohol exposure in mice
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53. Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice
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54. Programmed Death-1 Deficiency Aggravates Motor Dysfunction in MPTP Model of Parkinson's Disease by Inducing Microglial Activation and Neuroinflammation in Mice
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55. Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis
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56. Advances in proteomic phenotyping of microglia in neurodegeneration
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57. The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety‐Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology
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58. Bridging regional neurovascular unit heterogeneity and cognitive function: a review
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59. State-specific enhancer landscapes govern microglial plasticity
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60. Genome integrity and inflammation in the nervous system
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61. TIAM2S ‐positive microglia enhance inflammation and neurotoxicity through soluble ICAM ‐1‐mediated immune priming
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62. The dichotomous activities of microglia: A potential driver for phenotypic heterogeneity in Alzheimer’s disease
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63. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice
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64. Autophagy‐mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization
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65. Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex
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66. Catch me if you can: SARS-CoV-2 detection in brains of deceased patients with COVID-19
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67. Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice
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68. Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects
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69. Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
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70. Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair
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71. Antiretroviral therapy restores the homeostatic state of microglia in SIV-infected rhesus macaques
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72. Microgliosis: a double‐edged sword in the control of food intake
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73. A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes
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74. Single‐cell analysis of microglial transcriptomic diversity in subarachnoid haemorrhage
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75. Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
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76. TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
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77. Aging spinal cord microglia become phenotypically heterogeneous and preferentially target motor neurons and their synapses
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78. Tracking changes in functionality and morphology of repopulated microglia in young and old mice
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81. Brain transcriptome analysis of a CLN2 mouse model as a function of disease progression
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82. Circulatory proteins shape microglia state and boost phagocytosis
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83. Microglial STING is a central safeguard against neurological decline with age
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85. Microglia in Neuropathic Pain
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87. Reawakening inflammation in the chronically injured spinal cord using lipopolysaccharide induces diverse microglial states
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89. The roles of immune factors in neurodevelopment
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90. Anti-Inflammatory Effects of Cannabinoids in Therapy of Neurodegenerative Disorders and Inflammatory Diseases of the CNS
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91. Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype
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92. Overview for the study of P2 receptors: From P2 receptor history to neuropathic pain studies
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93. A Rapamycin-Inducible Glial-Neurovascular Network Promotes Adaptation after Chronic Social Defeat
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94. Tissue-specific features of microglial innate immune responses
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95. A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms
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96. Brain Transcriptome Responses to Dexamethasone Depending on Dose and Sex Reveal Factors Contributing to Sex-Specific Vulnerability to Stress-Induced Disorders
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97. IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry
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98. Brain region-specific myelinogenesis is not directly linked to amyloid-β in APP/PS1 transgenic mice
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99. A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma
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100. Forward programming human pluripotent stem cells into microglia
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