Microglia Heterogeneity in the Single-Cell Era

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Items 201–300 of 793

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2. Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys
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3. PM2.5-induced ferroptosis by Nrf2/Hmox1 signaling pathway led to inflammation in microglia
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4. Microglia-Mediated Neuroinflammation Through Phosphatidylinositol 3-Kinase Signaling Causes Cognitive Dysfunction
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5. Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration
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6. Dendrimers as Modulators of Brain Cells
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7. Microglia and its Genetics in Alzheimer's Disease
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8. Microbial pathogens induce neurodegeneration in Alzheimer’s disease mice: protection by microglial regulation
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9. Nanoparticle-based targeting of microglia improves the neural regeneration enhancing effects of immunosuppression in the zebrafish retina
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10. Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice
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11. Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal
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12. Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease
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13. Spatiotemporal characterization of glial cell activation in an Alzheimer’s disease model by spatially resolved transcriptomics
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14. Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states
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15. Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices
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16. OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis
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17. Microglia and Stem-Cell Mediated Neuroprotection after Neonatal Hypoxia-Ischemia
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18. Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
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19. Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease
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20. Microglial crosstalk with astrocytes and immune cells in amyotrophic lateral sclerosis
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21. A dynamic and multimodal framework to define microglial states
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22. Metabolic regulation of immune memory and function of microglia
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23. Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance
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24. Aß Pathology and Neuron–Glia Interactions: A Synaptocentric View
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25. Microglia–neuron–vascular interactions in ischemia
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26. SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages
    Tianxi Wang, Satoshi Kaneko, Emil Kriukov, David Álvarez, Enton Lam, Yidi Wang, Sara La Manna, Daniela Marasco, Angeles Fernandez‐Gonzalez, S. Alex Mitsialis et al. · 2024 · Molecular Therapy
27. The dual role of microglia in ischemic stroke and its modulation via extracellular vesicles and stem cells
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28. Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States
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29. Secondary thalamic neuroinflammation after focal cortical stroke and traumatic injury mirrors corticothalamic functional connectivity
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30. Roles of Fatty Acids in Microglial Polarization: Evidence from In Vitro and In Vivo Studies on Neurodegenerative Diseases
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31. Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury
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32. Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer’s disease
    George Sideris-Lampretsas, Silvia Oggero, Lynda Zeboudj, Rita Silva, Archana Bajpai, Gopuraja Dharmalingam, David Andrew Collier, Marzia Malcangio · 2023 · Nature Communications
33. Macrophages and autophagy: partners in crime
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34. Neuroinflammation across the Spectrum of Neurodegenerative Diseases: Mechanisms and Therapeutic Frontiers
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35. High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
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36. Targeting PKC in microglia to promote remyelination and repair in the CNS
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37. Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke
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38. FKBP51 is involved in LPS-induced microglial activation via NF-κB signaling to mediate neuroinflammation
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39. Evolving Models and Tools for Microglial Studies in the Central Nervous System
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40. Adult neurogenesis in the primate hippocampus
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41. Ensheathing glia promote increased lifespan and healthy brain aging
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42. MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state
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43. Neuroinflammation and blood–brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications
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44. Evaluating microglial phenotypes using single-cell technologies
    Roman Sankowski, Gianni Monaco, Marco Prinz · 2021 · Trends in Neurosciences
45. The Effect of C-Phycocyanin on Microglia Activation Is Mediated by Toll-like Receptor 4
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46. In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity
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47. Lipoxygenase Metabolism: Critical Pathways in Microglia-mediated Neuroinflammation and Neurodevelopmental Disorders
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48. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia
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49. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
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50. Microglia morphotyping in the adult mouse CNS using hierarchical clustering on principal components reveals regional heterogeneity but no sexual dimorphism
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51. Lipid in microglial biology — from material to mediator
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52. Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology
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53. Dynamic regulation and targeted interventions of macrophages in ischemia–reperfusion injury
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54. Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets
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55. Role of lipid droplets in neurodegenerative diseases: From pathogenesis to therapeutics
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56. Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis
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57. The Complementary Role of Morphology in Understanding Microglial Functional Heterogeneity
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58. The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review
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59. New insights into acute ischemic stroke from the perspective of spatial omics
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60. Is postoperative cognitive dysfunction a disease of microglial inflammatory memory? A state-transition model from metabolic stress to epigenetic lock-in
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61. Pathways linking Alzheimer’s disease risk genes expressed highly in microglia
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62. Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders
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63. Novel cell-based analysis reveals region-dependent changes in microglial dynamics in grey matter in a cuprizone model of demyelination
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64. p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial Transcriptional States
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65. The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia
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66. The zinc finger transcription factor Sall1 is required for the early developmental transition of microglia in mouse embryos
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67. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model
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68. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas
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69. Type I interferon signalling and interferon‐responsive microglia in health and disease
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70. Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?
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71. Microglia Morphological Changes in the Motor Cortex of hSOD1G93A Transgenic ALS Mice
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72. Recent Advances in Microglia Modelling to Address Translational Outcomes in Neurodegenerative Diseases
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73. The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease
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74. The Role of Microglial Depletion Approaches in Pathological Condition of CNS
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75. Metabolic reprogramming regulates microglial polarization and its role in cerebral ischemia reperfusion
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76. A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization
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77. Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
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78. Single-cell sequencing of the substantia nigra reveals microglial activation in a model of MPTP
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79. Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization
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80. Mechanisms of action of retinal microglia in diabetic retinopathy (Review)
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81. Inflammation Unleashed in Viral-Induced Epileptogenesis
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82. Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory responses of microglia/macrophages
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83. Reactive morphology of dividing microglia following kainic acid administration
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84. Botulinum Neurotoxins beyond Neurons: Interplay with Glial Cells
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85. Lipid Signatures and Inter-Cellular Heterogeneity of Naıve and Lipopolysaccharide-Stimulated Human Microglia-like Cells
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86. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress
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87. Anti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine
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89. Microglia pack a toolbox for life
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90. Deciphering the heterogeneity of myeloid cells during neuroinflammation in the single‐cell era
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91. Towards high throughput and high information coverage: advanced single-cell mass spectrometric techniques
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92. Alterations in Chromatin Structure and Function in the Microglia
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93. The Growing Relevance of Immunoregulation in Pediatric Brain Tumors
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94. Ouabain Ameliorates Alzheimer’s Disease-Associated Neuropathology and Cognitive Impairment in FAD4T Mice
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95. Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?
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96. Inhibiting Cyclin B1-treated Pontine Infarction by Suppressing Proliferation of SPP1+ Microglia
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97. APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
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98. Single‐microglia transcriptomic transition network‐based prediction and real‐world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease
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99. Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures
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100. Alzheimer’s Disease, Obesity, and Type 2 Diabetes: Focus on Common Neuroglial Dysfunctions (Critical Review and New Data on Human Brain and Models)
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