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Cited by 50Neurobiology and Insect Physiology ResearchVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila

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Keleş, Mehmet F., Hardcastle, Ben J., Städele, Carola, Xiao, Qi, Frye, Mark A.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.01.061PMC PMC7210872
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Abstract

The direction-selective T4/T5 cells innervate optic-flow processing projection neurons in the lobula plate of the fly that mediate the visual control of locomotion. In the lobula, visual projection neurons coordinate complex behavioral responses to visual features, however, the input circuitry and computations that bestow their feature-detecting properties are less clear. Here, we study a highly specialized small object motion detector, LC11, and demonstrate that its responses are suppressed by local background motion. We show that LC11 expresses GABA-A receptors that serve to sculpt responses to small objects but are not responsible for the rejection of background motion. Instead, LC11 is innervated by columnar T2 and T3 neurons that are themselves highly sensitive to small static or moving objects, insensitive to wide-field motion and, unlike T4/T5, respond to both ON and OFF luminance steps.

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  • Thus, one can implement one's own sensory processing model with the level of biological realism required to address the question at hand.

    “Thus, one can implement one's own sensory processing model with the level of biological realism required to address the question at hand (e.g., visual optic flow algorithms 76 , connectome-constrained visual feature extraction 43 , olfactory gain control 77 , odor motion sensing algorithms 78 , olfactory memory formation 72 ; see Table 1 ).”

    From NeuroMechFly v2: simulating embodied sensorimotor control in adult Drosophila (2024) · cites this paper as [76]

    The Discussion (Role of Inhibition in Sculpting LC11 Object Selectivity; page unavailable) proposes a working model of how inhibitory and columnar inputs shape visual object detection. That supports the visual-feature-extraction aspect of the example, but the paper does not describe implementing a connectome-constrained sensory-processing model; its Methods describe anatomical and experimental analyses instead. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Keleş, M. F., Hardcastle, B. J., Städele, C., Xiao, Q., & Frye, M. A.
Affiliations
  • University of California, Los Angeles (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Frye, Mark A.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2020-02
Volume
30
Issue
7
Pages
2115-2124.e5
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2020.01.061
PMC
PMC7210872
OpenAlex
W3008087290
Cited by
50
References
7
Citations by year
2026: 5 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 5 · 2020: 6
FWCI
3.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Eye Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
moving object detection, GABAA receptor, optical flow, visual control of locomotion
MeSH terms
Animals, Drosophila, Drosophila melanogaster, Motion Perception

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