Transsynaptic mapping of second-order taste neurons in flies by trans-Tango
Open accessAbstract
Mapping neural circuits across defined synapses is essential for understanding brain function. Here we describe trans-Tango, a technique for anterograde transsynaptic circuit tracing and manipulation. At the core of trans-Tango is a synthetic signaling pathway that is introduced into all neurons in the animal. This pathway converts receptor activation at the cell surface into reporter expression through site-specific proteolysis. Specific labeling is achieved by presenting a tethered ligand at the synapses of genetically defined neurons, thereby activating the pathway in their postsynaptic partners and providing genetic access to these neurons. We first validated trans-Tango in the Drosophila olfactory system and then implemented it in the gustatory system, where projections beyond the first-order receptor neurons are not fully characterized. We identified putative second-order neurons within the sweet circuit that include projection neurons targeting known neuromodulation centers in the brain. These experiments establish trans-Tango as a flexible platform for transsynaptic circuit analysis.
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Genetic trans-synaptic labeling methods may give false positives and negatives.
“However, the genetic methods may give false positives and negatives”
From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Talay et al., 2017
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- Authors
- Talay, M., Richman, E. B., Snell, N. J., Hartmann, G. G., Fisher, J. D., Sorkaç, A., Santoyo, J. F., Chou-Freed, C., Nair, N., Johnson, M., Szymanski, J. R., & Barnea, G.
- Affiliations
- Brown University (US)
- Corresponding author
- Barnea, Gilad
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 96
- Issue
- 4
- Pages
- 783-795.e4
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5693608
- OpenAlex
- W2765562046
- Cited by
- 301
- References
- 82
- Citations by year
- 2026: 26 · 2025: 31 · 2024: 53 · 2023: 39 · 2022: 35 · 2021: 40 · 2020: 38 · 2019: 18 · 2018: 20 · 2017: 1
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R21DCO14333, R01MH086920, R01MH105368, R01DC013561)
- Brown University: BIBS Innovation Award
- OVPR Salomon and Seed Awards
- Pew Charitable Trus
- Suna & İnan Kıraç Foundation
- BIBS
- Karen T. Romer UTRA (DGE1058262)
- National Science Foundation Graduate Research Fellowship Program
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- gustatory system, Drosophila, site-specific proteolysis, tethered ligand, projection neurons, neuromodulation, olfactory system, neural circuit mapping
- MeSH terms
- Animals, Drosophila, Neural Pathways, Neurons, Olfactory Pathways, Animals, Genetically Modified, Taste Perception, Neuroanatomical Tract-Tracing Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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