Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Melo, Helen M., Seixas da Silva, Gisele da S., Sant’Ana, Marcella Ramos, Teixeira, Camila Vieira Ligo, Clarke, Julia R., Miya Coreixas, Vivian S., de Melo, Bruno C., Fortuna, Juliana T.S. +13 more·2020·Cell Reports

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  1. Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity
    Danbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Song · 2024 · Clinical Nutrition Research
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    Krittika Srisuksai, Kongphop Parunyakul, Pitchaya Santativongchai, Sumate Ampawong, Phitsanu Tulayakul, Wirasak Fungfuang · 2023 · Sains Malaysiana
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    Sivaraman Kuppuswamy, Kripa Patel, Wenbo Zhi, Vijay Chaitanya Ganta · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
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  13. Decreased brain entropy in the left pallidum is associated with memory impairment in obese individuals: Evidence from resting-state fMRI
    Kunpeng Cheng, Jia Ming Hu, Liangping Ni, Qi Xue, Dai Zhang, Ye Zhang, Huang Chunxia, Longsheng Wang · 2025 · Brain Research
  14. Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain
    Meenakshi Chakraborty, Sophia M. Shi, Imani E. Porter, Daniel J. Richard, Georgi K. Marinov, Mukundh N. Murthy, Ashley A. Moore, Jenna Lynn Elizabeth Blum, Aravind Natarajan, James W.S. Jahng et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. CNS-PENETRANT NLRP3 INHIBITOR ACHIEVES DURABLE WEIGHT LOSS AND REVERSES HYPOTHALAMIC INFLAMMATION IN DIET-INDUCED OBESITY
    Jing Guo, Tomás P. Bachor, Ryan Takahashi, Micah Steffek, Gabriel A. Fitzgerald, Benjamin J. Huffman, Dylan Braun, Suk Ji Han, Thomas Sandmann, Connie Ha et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Gaining Quadruple Points
    Gilbert Chin · 2005 · Science
  17. Análisis proteómico de la respuesta protectora mediada por el esteroide sintético Tibolona frente a un insulto lipotóxico en astrocitos humanos
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    Suset Rodriguez, Ramakrishnan Thiruchelvi, Arokiasamy Justin Thenmozhi, Daniela S. Cosio, Nagarajarao Shamaladevi, Hussain Hussain, Sampath Natarajan, Michael John Paidas, Arumugam Radhakrishnan Jayakumar · 2023 · Nutritional neurosciences
  19. Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolism
    Gabriela Cristina de Paula, Blanca I. Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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    Felipe Corrêa‐da‐Silva, Chun‐Xia Yi · 2025 · Handbook of clinical neurology
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    Xianyi Ding, Wenhong Wang, Jiabin Wu, Ke Li, Haoyang Gao, Mingyu Wu, Lvhao Dong, Weihua Xiao · 2025 · Biochemical Pharmacology
  23. Additional file 1 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  24. Additional file 5 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  25. Additional file 7 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  26. Additional file 1 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
    Yun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
  27. Additional file 5 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  28. Additional file 2 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
    Yun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
  29. Additional file 2 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  30. Additional file 4 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  31. Additional file 3 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  32. Additional file 6 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  33. Additional file 2 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  34. Additional file 3 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
    Yun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
  35. Additional file 4 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
    Aimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
  36. Additional file 3 of Extracellular vesicles released from microglia after palmitate exposure impact brain function
    Gabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
  37. Additional file 4 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
    Yun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
  38. Role of Cell Surface Receptors in Palmitic Acid-Induced Expression of IL-1β in Microglial Cells
    Viren Jadeja, Shiyu Ma, Heping Zhou · 2026 · Lipidology
  39. Polygala oligosaccharide esters improve memory disorder by restoring gut microbiota homeostasis through the regulation of the “gut-brain” axis
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  41. AMPK Activator MK ‐8722 Improves Spatial Memory Deficit and Alters Metabolome in APP / PS1 AD Mouse Model
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  42. Study on the global and national burden of Alzheimer's disease attributable to dietary fatty acids from 1990 to 2018: A combined analysis based on the global burden of disease and global dietary database
    Liuhui Zhu, Jie Liu, Jianzhun Chen, Longfeng Yang, Shimei Li, Xinglong Yang · 2026 · Journal of Alzheimer s Disease
  43. Syringic acid improves cognitive impairment in palmitic acid-induced obesity model: an in vitro and in vivo study
    Amina Khatun, Jayasree Saha, Priti Garai, Susovan Chowdhury, Surendra Patra, Ritobrata Goswami, Shrabani Pradhan, Kuntal Ghosh, Sudipta Chakrabarti · 2026 · Nutritional Neuroscience