Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α
Melo, Helen M., Seixas da Silva, Gisele da S., Sant’Ana, Marcella Ramos, Teixeira, Camila Vieira Ligo, Clarke, Julia R., Miya Coreixas, Vivian S., de Melo, Bruno C., Fortuna, Juliana T.S. +13 more·2020·Cell Reports
Cited by (143)
Items 101–143 of 143
- Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced NeurotoxicityDanbi Jo, Seo Yeon Ahn, Seo Yoon Choi, Yoonjoo Choi, Dong Hoon Lee, Juhyun Song · 2024 · Clinical Nutrition Research
- Reducing PTP1B in the Hippocampus Protects Against Cognitive Decline in PrediabetesMenglu Zhou, Xiaoying Yang, Xing Ge, Jiajia Chen, Weifeng Wu, Mingxuan Zheng, Xiaoying Cui, Xiaocheng Zhu, Renxian Tang, Kuiyang Zheng et al. · 2025 · Diabetes
- Chronic Fatty Acid Exposure Disrupts SH-SY5Y and Neuronal Differentiation and Is a Potential Link Between Type-2 Diabetes and Alzheimer’s DiseaseImogen L. Targett, Kate Pring, Ana I. Martinez Valiente, David Qualtrough, Myra E. Conway, Lucy Crompton, Tim J. Craig · 2025 · Molecular Neurobiology
- Mesenchymal stromal cells can block palmitate training of macrophages via cyclooxygenase-2 and interleukin-1 receptor antagonistL. Bitterlich, Courteney Tunstead, Andrew E. Hogan, James A. Ankrum, Karen English · 2024 · Cytotherapy
- Understanding the neurobiological mechanisms of LPS‑induced memory impairmentAhmad Golkar, Mohammad Dalfardi, Mahdiyeh Hedayati‐Moghadam, Hedyeh Askarpour, Mahmoud Hosseini, Yousef Baghcheghi · 2025 · Acta Neurobiologiae Experimentalis
- Avocado Oil: Recent Advances in Its Anti-diabetic PotentialDorji Drakpa, Taniya Paul, Sukriti Chakrabarty, Karma Jigdrel, Prasun Mukherjee, Jeena Gupta · 2025 · Current Medical Science
- Effect of Crocodile Oil (Crocodylus siamensis) on Brain Mitochondrial Protein Expression and Cognition in Male RatsKrittika Srisuksai, Kongphop Parunyakul, Pitchaya Santativongchai, Sumate Ampawong, Phitsanu Tulayakul, Wirasak Fungfuang · 2023 · Sains Malaysiana
- The Pro-vs. Anti-Angiogenic Capacity of Short Chain Fatty Acids is Dependent on the Bioavailability of FFAR3 in Peripheral Artery DiseaseSivaraman Kuppuswamy, Kripa Patel, Wenbo Zhi, Vijay Chaitanya Ganta · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Role of CTRP9 in obesity-associated microglial dysregulation: Promoting lipophagy via the PI3K/AKT/FOXO1 signaling pathwayPeng-quan Chen, Ya-Dong Wei, Zheng Xp, Quan-Tong Xu, Songlin Xu, Shuai He, Meng-Jie Xu, Jin‐Fang Ge · 2026 · Cellular Signalling
- Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and cognitive decline in miceXinyi Xia, Fangfang Yi, Ruihang Zhang, Ruicong Wu, Xinyou Zhang, Yu Zhang, Jiaxin Liu, Haoyu Qin, Bingqin He, Yifan Duan et al. · 2026 · Experimental Neurology
- The Interaction Between Insulin Resistance and Neuroinflammation in the Brain and Its Impact on Diabetic EncephalopathyYue Wang, Hanyu Li, Xiaoxu Yang, Mei Yang, Wei Hu, Xihua Cheng, Yancheng Zhong · 2026 · Biology
- Mitochondrial dysfunction and metabolic syndromeAritri Bir, Arindam Ghosh, Walter E. Müller, Anirban Ganguly · 2024 · Elsevier eBooks
- Decreased brain entropy in the left pallidum is associated with memory impairment in obese individuals: Evidence from resting-state fMRIKunpeng Cheng, Jia Ming Hu, Liangping Ni, Qi Xue, Dai Zhang, Ye Zhang, Huang Chunxia, Longsheng Wang · 2025 · Brain Research
- Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainMeenakshi Chakraborty, Sophia M. Shi, Imani E. Porter, Daniel J. Richard, Georgi K. Marinov, Mukundh N. Murthy, Ashley A. Moore, Jenna Lynn Elizabeth Blum, Aravind Natarajan, James W.S. Jahng et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- CNS-PENETRANT NLRP3 INHIBITOR ACHIEVES DURABLE WEIGHT LOSS AND REVERSES HYPOTHALAMIC INFLAMMATION IN DIET-INDUCED OBESITYJing Guo, Tomás P. Bachor, Ryan Takahashi, Micah Steffek, Gabriel A. Fitzgerald, Benjamin J. Huffman, Dylan Braun, Suk Ji Han, Thomas Sandmann, Connie Ha et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Gaining Quadruple PointsGilbert Chin · 2005 · Science
- Análisis proteómico de la respuesta protectora mediada por el esteroide sintético Tibolona frente a un insulto lipotóxico en astrocitos humanosDiego Julián Vesga-Jiménez · 2021
- Fat and Alzheimer’s DiseaseSuset Rodriguez, Ramakrishnan Thiruchelvi, Arokiasamy Justin Thenmozhi, Daniela S. Cosio, Nagarajarao Shamaladevi, Hussain Hussain, Sampath Natarajan, Michael John Paidas, Arumugam Radhakrishnan Jayakumar · 2023 · Nutritional neurosciences
- Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolismGabriela Cristina de Paula, Blanca I. Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- An acute microglial metabolic response controls metabolism and improves memoryAnne Drougard, Eric H. Ma, Vanessa Wegert, Ryan D. Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens et al. · 2024 · eLife
- Neuroglia in eating disorders (obesity, Prader-Willi syndrome and anorexia nervosa)Felipe Corrêa‐da‐Silva, Chun‐Xia Yi · 2025 · Handbook of clinical neurology
- Stimulator of interferon genes: A potential target for treating type 2 diabetes mellitusXianyi Ding, Wenhong Wang, Jiabin Wu, Ke Li, Haoyang Gao, Mingyu Wu, Lvhao Dong, Weihua Xiao · 2025 · Biochemical Pharmacology
- Additional file 1 of Extracellular vesicles released from microglia after palmitate exposure impact brain functionGabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
- Additional file 5 of Extracellular vesicles released from microglia after palmitate exposure impact brain functionGabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
- Additional file 7 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 1 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cellsYun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
- Additional file 5 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 2 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cellsYun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
- Additional file 2 of Extracellular vesicles released from microglia after palmitate exposure impact brain functionGabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
- Additional file 4 of Extracellular vesicles released from microglia after palmitate exposure impact brain functionGabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
- Additional file 3 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 6 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 2 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 3 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cellsYun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
- Additional file 4 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brainAimée Parker, Stefano Romano, Rebecca Ansorge, Aboelnour, Asmaa, Le Gall, Gwenaelle, George M. Savva, Matthew G. Pontifex, Andrea Telatin, Baker, David, Emily J. Jones et al. · 2022 · Figshare
- Additional file 3 of Extracellular vesicles released from microglia after palmitate exposure impact brain functionGabriela Cristina de Paula, Blanca Aldana, Roberta Battistella, Rosalía Fernández‐Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João M. N. Duarte · 2024 · Figshare
- Additional file 4 of Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cellsYun Lim, Seolsong Kim, Kim, Eun-Kyoung · 2021 · Figshare
- Role of Cell Surface Receptors in Palmitic Acid-Induced Expression of IL-1β in Microglial CellsViren Jadeja, Shiyu Ma, Heping Zhou · 2026 · Lipidology
- Polygala oligosaccharide esters improve memory disorder by restoring gut microbiota homeostasis through the regulation of the “gut-brain” axisYan Wang, Chaoyun Ren, Wenkai Dong, Qiule Li, Fanying Deng, Fuxia Zhao, Yangang Cheng, Peng Sun, Huifang Li, Yingli Wang · 2026 · Chinese Medicine
- High-fat diet–induced obesity is associated with hyperinsulinemia and ovarian lipid remodeling without overt inflammationT.S. Rios, Susana Castelo Branco Ramos Nakandakari, R.F.L. Vieira, C.O. Ramos, G.R. Gonçalves, Érika Pereira Zambalde, Fernando Moreira Simabuco, A.S.R. Silva, L.P. Moura, E.R. Ropelle et al. · 2026 · The Journal of Nutritional Physiology
- AMPK Activator MK ‐8722 Improves Spatial Memory Deficit and Alters Metabolome in APP / PS1 AD Mouse ModelNoelle Isabella Nicol, Tian Li, Qiang Su, Amelia Suhocki, Erin Dunlap, 周雪艳, Hannah M. Jester, Nathaniel A. Swift, Ethan B. Underwood, Jingyun Lee et al. · 2026 · Journal of Neurochemistry
- Study on the global and national burden of Alzheimer's disease attributable to dietary fatty acids from 1990 to 2018: A combined analysis based on the global burden of disease and global dietary databaseLiuhui Zhu, Jie Liu, Jianzhun Chen, Longfeng Yang, Shimei Li, Xinglong Yang · 2026 · Journal of Alzheimer s Disease
- Syringic acid improves cognitive impairment in palmitic acid-induced obesity model: an in vitro and in vivo studyAmina Khatun, Jayasree Saha, Priti Garai, Susovan Chowdhury, Surendra Patra, Ritobrata Goswami, Shrabani Pradhan, Kuntal Ghosh, Sudipta Chakrabarti · 2026 · Nutritional Neuroscience