Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α
Open accessAbstract
Obesity has been associated with cognitive decline, atrophy of brain regions related to learning and memory, and higher risk of developing dementia. However, the molecular mechanisms underlying these neurological alterations are still largely unknown. Here, we investigate the effects of palmitate, a saturated fatty acid present at high amounts in fat-rich diets, in the brain. Palmitate is increased in the cerebrospinal fluid (CSF) of overweight and obese patients with amnestic mild cognitive impairment. In mice, intracerebroventricular infusion of palmitate impairs synaptic plasticity and memory. Palmitate induces astroglial and microglial activation in the mouse hippocampus, and its deleterious impact is mediated by microglia-derived tumor necrosis factor alpha (TNF-α) signaling. Our results establish that obesity is associated with increases in CSF palmitate. By defining a pro-inflammatory mechanism by which abnormal levels of palmitate in the brain impair memory, the results further suggest that anti-inflammatory strategies may attenuate memory impairment in obesity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Palmitate has anti-inflammatory effects in microglial cells.
“has anti-inflammatory effects in microglial cells [58, 80, 119].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [80]
Cites
1 retracted
Marwarha, G., Claycombe, K., Schommer, J., Collins, D., & Ghribi, O. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.08.012 · Cited by 56 · see citing works
RetractedFiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S., & Marks, J. S. (2003) · JAMA · doi:10.1001/jama.289.1.76 · Cited by 5,866 · see citing works
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works
Guh, D. P., Zhang, W., Bansback, N., Amarsi, Z., Birmingham, C. L., & Anis, A. H. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-88 · Cited by 3,855 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Diet, lifestyle, and the risk of type 2 diabetes mellitus in women.
Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010492 · Cited by 2,901 · see citing works
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570 · see citing works
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914 · see citing works
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works
Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men
Chan, J. M., Rimm, E. B., Colditz, G. A., Stampfer, M. J., & Willett, W. C. (1994) · Diabetes Care · doi:10.2337/diacare.17.9.961 · Cited by 1,808 · see citing works
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677 · see citing works
Innate immune activation in neurodegenerative disease
Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437 · see citing works
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,344 · see citing works
Lipidomics reveals a remarkable diversity of lipids in human plasma
Quehenberger, O., Armando, A. M., Brown, A., Milne, S. B., Myers, D. S., Merrill, A. H., Bandyopadhyay, S., Jones, K. N., Kelly, S. L., Shaner, R. L., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009449 · Cited by 1,322 · see citing works
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291 · see citing works
Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates
Paxinos, G., & Franklin, K. B. J. (2012) · Cited by 1,267 · see citing works
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M. L., Anhe, G., Amaral, M. E., Takahashi, H. K., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2760-08.2009 · Cited by 1,125 · see citing works
Self-citationVessby, B., Uusitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nälsén, C., Berglund, L., Louheranta, A., Rasmussen, B. M., et al. (2001) · Diabetologia · doi:10.1007/s001250051620 · Cited by 1,119 · see citing works
Body Mass Index, Waist Circumference, and Health Risk
Janssen, I., Katzmarzyk, P. T., & Ross, R. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.18.2074 · Cited by 958 · see citing works
McCoy, M. K., & Tansey, M. G. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-45 · Cited by 843 · see citing works
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
Jankowsky, J. L., Slunt, H. H., Ratovitski, T., Jenkins, N. A., Copeland, N. G., & Borchelt, D. (2001) · Biomolecular Engineering · doi:10.1016/s1389-0344(01)00067-3 · Cited by 819 · see citing works
Central obesity and increased risk of dementia more than three decades later
Whitmer, R. A., Gustafson, D. R., Barrett-Connor, E., Haan, M. N., Gunderson, E. P., & Yaffe, K. (2008) · Neurology · doi:10.1212/01.wnl.0000306313.89165.ef · Cited by 803 · see citing works
The role of TNFα and TNF receptors in obesity and insulin resistance
Hotamisligil, G. S. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00490.x · Cited by 780 · see citing works
A network diffusion model of disease progression in dementia
Raj, A., Kuceyeski, A., & Weiner, M. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.040 · Cited by 723 · see citing works
Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
Elias, M. F., Elias, P. K., SULLIVAN, L. M., Wolf, P. A., & D’Agostino, R. B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.802225 · Cited by 691 · see citing works
Association of diabetes mellitus and dementia, the Rotterdam study
Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. B. (1996) · Diabetologia · doi:10.1007/s001250050588 · Cited by 677 · see citing works
De Felice, F. G., Vieira, M. N. N., Bomfim, T. R., Decker, H., Velasco, P. T., Lambert, M. P., Viola, K. L., Zhao, W.-Q., Ferreira, S. T., & Klein, W. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809158106 · Cited by 657 · see citing works
Self-citationValdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629 · see citing works
Dietary Fats and the Risk of Incident Alzheimer Disease
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C., Bennett, D. A., Aggarwal, N. T., Schneider, J. S., & Wilson, R. S. (2003) · Archives of Neurology · doi:10.1001/archneur.60.2.194 · Cited by 530 · see citing works
Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
Kalmijn, S., van Boxtel, M. P. J., Ocké, M., Verschuren, W. M. M., Kromhout, D., & Launer, L. J. (2004) · Neurology · doi:10.1212/01.wnl.0000103860.75218.a5 · Cited by 524 · see citing works
Takeda, S., Sato, N., Uchio‐Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., & Morishita, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000645107 · Cited by 506 · see citing works
Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice
Gruart, A., Muñoz, M.-D., & Delgado-Garcia, J. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2834-05.2006 · Cited by 460 · see citing works
Self-citationIsolation and culture of adult rat hippocampal neurons
Brewer, G. J. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(96)00136-7 · Cited by 447 · see citing works
Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901488200 · Cited by 426 · see citing works
Chiu, S.-L., Chen, C.-M., & Cline, H. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.014 · Cited by 425 · see citing works
Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 415 · see citing works
Self-citationIntracerebroventricular injections in mice
Laursen, S. E., & Belknap, J. K. (1986) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(86)90038-0 · Cited by 393 · see citing works
Jeon, B. T., Jeong, E. A., Shin, H. J., Lee, Y., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., & Roh, G. S. (2012) · Diabetes · doi:10.2337/db11-1498 · Cited by 352 · see citing works
Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works
Ajuwon, K. M., & Spurlock, M. E. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.8.1841 · Cited by 343 · see citing works
A 24-year follow-up of body mass index and cerebral atrophy
Gustafson, D., Lissner, L., Bengtsson, C., Björkelund, C., & Skoog, I. G. (2004) · Neurology · doi:10.1212/01.wnl.0000141850.47773.5f · Cited by 339 · see citing works
Arnold, S., Lucki, I., Brookshire, B. R., Carlson, G., Browne, C., Kazi, H., Bang, S., Choi, B.-R., Chen, Y., McMullen, M. F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.011 · Cited by 309 · see citing works
Yuzefovych, L., Wilson, G., & Rachek, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2010 · Cited by 280 · see citing works
Adiposity indices and dementia
Gustafson, D. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70526-9 · Cited by 237 · see citing works
Knight, E. M., Martins, I. V. A., Gümüsgöz, S., Allan, S. M., & Lawrence, C. B. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.010 · Cited by 232 · see citing works
Mayer, C., & Belsham, D. D. (2009) · Endocrinology · doi:10.1210/en.2009-1122 · Cited by 232 · see citing works
Lee, C.-C., Huang, C., & Hsu, K. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.003 · Cited by 227 · see citing works
Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214 · see citing works
Self-citationParker, D., Weiss, S. T., Troisi, R. J., Cassano, P. A., Vokonas, P., & Landsberg, L. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.2.129 · Cited by 212 · see citing works
Association of type 2 diabetes with brain atrophy and cognitive impairment
Roberts, R. O., Knopman, D. S., Przybelski, S. A., Mielke, M. M., Kantarci, K., Preboske, G. M., Senjem, M. L., Pankratz, V. S., Geda, Y. E., Boeve, B. F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000269 · Cited by 211 · see citing works
Spinelli, M., Fusco, S., Mainardi, M., Scala, F., Natale, F., Lapenta, R., Mattera, A., Rinaudo, M., Puma, D. D. L., Ripoli, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02221-9 · Cited by 208 · see citing works
Obesity is linked with lower brain volume in 700 AD and MCI patients
Ho, A. J., Raji, C. A., Becker, J. T., López, O. L., Kuller, L. H., Hua, X., Lee, S., Hibar, D. P., Dinov, I. D., Stein, J. L., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.006 · Cited by 204 · see citing works
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 204 · see citing works
Arruda, A. P., Milanski, M., Coope, A., Torsoni, A. S., Ropelle, E. R., de Carvalho, D. P., Carvalheira, J. B. C., & Velloso, L. A. (2011) · Endocrinology · doi:10.1210/en.2010-0659 · Cited by 203 · see citing works
Self-citationBarnes maze, a useful task to assess spatial reference memory in the mice
Sunyer, B., Patil, S. S., Höger, H., & Luber, G. (2007) · Protocol Exchange · doi:10.1038/nprot.2007.390 · Cited by 201 · see citing works
Insulin resistance, inflammation, and serum fatty acid composition
Fernández-Real, J.-M., Broch, M., Vendrell, J., & Ricart, W. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1362 · Cited by 197 · see citing works
Figueiredo, C. P., Clarke, J. R., Ledo, J. H., Ribeiro, F. C., Costa, C., Melo, H. M., Mota-Sales, A. P., Saraiva, L. M., Klein, W. L., Sebollela, A. S., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0482-13.2013 · Cited by 181 · see citing works
Self-citationJové, M., Planavila, A., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez-Carrera, M. (2006) · Endocrinology · doi:10.1210/en.2005-0440 · Cited by 172 · see citing works
Insulin regulation of regional free fatty acid metabolism.
Meek, S., Nair, K. S., & Jensen, M. D. (1999) · Diabetes · doi:10.2337/diabetes.48.1.10 · Cited by 170 · see citing works
Takechi, R., Lam, V., Brook, E., Giles, C., Fimognari, N., Mooranian, A., Al‐Salami, H., Coulson, S., Nesbit, M., & Mamo, J. C. L. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00399 · Cited by 169 · see citing works
Postprandial Free Fatty Acid Kinetics Are Abnormal in Upper Body Obesity
Roust, L. R., & Jensen, M. D. (1993) · Diabetes · doi:10.2337/diab.42.11.1567 · Cited by 164 · see citing works
Usual Dietary Fat Intake and Insulin Concentrations in Healthy Women Twins
Mayer, E. J., Newman, B. M., Quesenberry, C. P., & Selby, J. V. (1993) · Diabetes Care · doi:10.2337/diacare.16.11.1459 · Cited by 161 · see citing works
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice
Ledo, J. H., Azevedo, E. P., Clarke, J. R., Ribeiro, F. C., Figueiredo, C. P., Foguel, D., Felice, F. G. D., & Ferreira, S. T. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.168 · Cited by 156 · see citing works
Self-citationLedo, J. H., Azevedo, E. P., Beckman, D., Ribeiro, F. C., Santos, L. E., Razolli, D. S., Kincheski, G. C., Melo, H. M., Bellio, M., Teixeira, A. L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1269-16.2016 · Cited by 137 · see citing works
Self-citationDirect methylation from mouse plasma and from liver and brain homogenates
Shirai, N., Suzuki, H., & Wada, S. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.037 · Cited by 95 · see citing works
Cheng, L., Yu, Y., Szabo, A., Wu, Y., Wang, H., Camer, D., & Huang, X. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.12.011 · Cited by 80 · see citing works
Liu, L., Martin, R., & Chan, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.017 · Cited by 72 · see citing works
Azevedo, E. P., Ledo, J. H., Barbosa, G., Sobrinho, M., Diniz, L. P., da Fonseca, A. C. C., Gomes, F. C. A., Romão, L. F., Lima, F. R. S., Palhano, F. L., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.325 · Cited by 64 · see citing works
Self-citationMadroñal, N., Delgado-Garcia, J. M., & Gruart, A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3397-07.2007 · Cited by 53 · see citing works
Self-citationMagalhães, T. N. C., Weiler, M., Teixeira, C. V. L., Hayata, T., Moraes, A. S., Boldrini, V. D. O., dos Santos, L. M., de Campos, B. M., de Rezende, T. J. R., Joaquim, H. P. G., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0795-9 · Cited by 51 · see citing works
Self-citationTeixeira, C. V. L., de Rezende, T. J. R., Weiler, M., Magalhães, T. N. C., Carletti‐Cassani, A. F. M. K., Quinaglia, T., Joaquim, H. P. G., Talib, L. L., Forlenza, O. V., Franco, M. P., et al. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.02.003 · Cited by 43 · see citing works
Self-citationQuantification of Free Fatty Acids in Human Cerebrospinal Fluid
Pilitsis, J. G., Diaz, F. G., Wellwood, J. M., O’Regan, M. H., Fairfax, M. R., Phillis, J. W., & Coplin, W. M. (2001) · Neurochemical Research · doi:10.1023/a:1014227231130 · Cited by 40 · see citing works
Razolli, D. S., Moraes, J. C., Morari, J., de Moura, R. F., Vinolo, M. A. R., & Velloso, L. A. (2014) · Endocrinology · doi:10.1210/en.2014-1552 · Cited by 40 · see citing works
Self-citationZhao, W., Wu, X., Xie, H., Ke, Y., & Yung, W. (2010) · Neurosignals · doi:10.1159/000324040 · Cited by 27 · see citing works
Weiler, M., de Campos, B. M., Teixeira, C. V. L., Casseb, R. F., Carletti‐Cassani, A. F. M. K., Vicentini, J. E., Magalhães, T. N. C., Talib, L. L., Forlenza, O. V., & Balthazar, M. L. F. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160190 · Cited by 27 · see citing works
Self-citationOverweight and Obesity as Determinants of Cardiovascular Risk: The Framingham Experience
Wilson, P. W. F., D'Agostino, R. B., Sullivan, L., Parise, H., & Kannel, W. B. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.16.1867 · Cited by 22 · see citing works
Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly
Teixeira, C. V. L., de Rezende, T. J. R., Weiler, M., Nogueira, M. H., de Campos, B. M., Pegoraro, L., Vicentini, J. E., Braz, G. S., Cendes, F., & Balthazar, M. L. F. (2016) · AGE · doi:10.1007/s11357-016-9912-3 · Cited by 21 · see citing works
Self-citationRabelo, A. G. B., Teixeira, C. V., Magalhães, T. N. C., Carletti‐Cassani, A. F. M. K., Filho, A. C. A., Joaquim, H. P. G., Talib, L. L., Forlenza, O. V., Ribeiro, P. A. O., Secolin, R., et al. (2017) · The Neuroradiology Journal · doi:10.1177/1971400917720465 · Cited by 13 · see citing works
Self-citationGinneken, V., Verheij, E. R., Hekman, M., & van der Greef, J. (2017) · Integrative Molecular Medicine · doi:10.15761/imm.1000278 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yin, F. (2023) · The FEBS Journal · doi:10.1111/febs.16344 · Cited by 441 · see citing works
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works
Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications
Si, Z.-Z., Zou, C.-J., Mei, X., Mei, X., Luo, H., Shen, Y., Hu, J., Li, X.-X., Wu, L., & Liu, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.353484 · Cited by 192 · see citing works
Lu, S., Zhao, Q., Yu, G., Sun, Z., Li, W., Guo, S., & Zhang, A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117207 · Cited by 182 · see citing works
The role of innate immunity in Alzheimer's disease
Ennerfelt, H. E., & Lukens, J. R. (2020) · Immunological Reviews · doi:10.1111/imr.12896 · Cited by 121 · see citing works
Vinuesa, Á., Pomilio, C. J., Gregosa, A., Bentivegna, M., Presa, J., Bellotto, M., Saravia, F., & Beauquis, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.653651 · Cited by 111 · see citing works
Dierssen, M., Fructuoso, M., de Lagrán, M. M., Marzia Perluigi, A., & Barone, E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00670 · Cited by 101 · see citing works
Vesga-Jiménez, D. J., Martin, C., Barreto, G. E., Aristizábal-Pachón, A. F., Pinzón, A. M., & González, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052577 · Cited by 100 · see citing works
Song, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114647 · Cited by 84 · see citing works
Hypothalamic inflammation in metabolic disorders and aging
Bhusal, A., Rahman, M. H., & Suk, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04019-x · Cited by 79 · see citing works
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions
Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 76 · see citing works
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
Alexaki, V. I. (2021) · Cells · doi:10.3390/cells10071584 · Cited by 83 · see citing works
Thornton, P., Reader, V., Digby, Z., Smolak, P. J., Lindsay, N. A., Harrison, D., Clarke, N., & Watt, A. P. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.002013 · Cited by 76 · see citing works
Bóbbo, V. C. D., Engel, D. F., Jara, C. P., Mendes, N. F., Haddad-Tóvolli, R., do Prado, T. P., Sidarta-Oliveira, D., Morari, J., Velloso, L. A., & ARAUJO, E. P. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02242-8 · Cited by 69 · see citing works
Self-citationde Almeida, V. M., Engel, D. F., Ricci, M. F., Cruz, C. S., Lopes, Í. S., Alves, D. A., Auriol, M. D., Magalhães, J., Machado, E. C., Rocha, V. M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2249146 · Cited by 67 · see citing works
Cao, Y., Zhao, L., Chen, Z., & Li, S. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1430465 · Cited by 58 · see citing works
Hammerschmidt, P., Steculorum, S. M., Bandet, C. L., Río-Martín, A. D., Steuernagel, L., Kohlhaas, V., Feldmann, M., Varela, L., Majcher, A., Correia, M. Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42595-7 · Cited by 60 · see citing works
Asimakidou, E., Saipuljumri, E. N., Lo, C. H., & Zeng, J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01770 · Cited by 60 · see citing works
Ferreira, S. T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12959 · Cited by 59 · see citing works
Self-citationGupta, P., Sharma, G., Lahiri, A., & Barthwal, M. K. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0620-348rr · Cited by 55 · see citing works
Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids
Urso, C. J., & Zhou, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169093 · Cited by 54 · see citing works
Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease
Mejido, D. C. P., Peny, J. A., Vieira, M. N. N., Ferreira, S. T., & Felice, F. G. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108115 · Cited by 53 · see citing works
Self-citationSánchez‐Alegría, K., & Arias, C. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.386 · Cited by 48 · see citing works
Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis
Folick, A., Koliwad, S. K., & Valdearcos, M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668396 · Cited by 45 · see citing works
Ghosh, P., Singh, R. B., Ganeshpurkar, A., Pokle, A. V., Singh, R. B., Singh, S. K., & Kumar, A. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105212 · Cited by 44 · see citing works
Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome
Corrêa‐da‐Silva, F., Fliers, E., Swaab, D. F., & Yi, C. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12994 · Cited by 39 · see citing works
S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
Buszka, A., Pytyś, A., Colvin, D., Włodarczyk, J., & Wójtowicz, T. (2023) · Cells · doi:10.3390/cells12030387 · Cited by 40 · see citing works
Sánchez‐Alegría, K., Bastián‐Eugenio, C. E., Vaca, L. A., & Arias, C. (2021) · The FASEB Journal · doi:10.1096/fj.202100243r · Cited by 40 · see citing works
Beaulieu, J., Costa, G., Renaud, J., Moitié, A., Glémet, H., Sergi, D., & Martinoli, M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02328-7 · Cited by 37 · see citing works
Vilas‐Boas, E. A., Nalbach, L., Ampofo, E., Lucena, C. F., Naudet, L., Ortis, F., Carpinelli, Â. R., Morgan, B., & Roma, L. P. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.023 · Cited by 33 · see citing works
Pharmacological Strategies to Improve Dendritic Spines in Alzheimer’s Disease
Ettcheto, M., Busquets, O., Cano, A. C., Sánchez‐López, E., Manzine, P. R., Espinosa-Jiménez, T., Verdaguer, E., Sureda, F. X., Olloquequi, J., Castro-Torres, R. D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201106 · Cited by 25 · see citing works
Kumari, P., Sood, A., Fernandes, V., Khan, I., Khatri, D. K., & Singh, S. B. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03933-y · Cited by 24 · see citing works
Boonyarattanasoonthorn, T., Kongratanapasert, T., Maiuthed, A., Hamlin, R. L., Kijtawornrat, A., & Khemawoot, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-24935-7 · Cited by 22 · see citing works
Role of Myeloid Cell-Specific TLR9 in Mitochondrial DNA-Induced Lung Inflammation in Mice
Dimasuay, K. G., Berg, B., Schaunaman, N., & Chu, H. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020939 · Cited by 20 · see citing works
Yang, Y., Hao, X., Zhang, J., Gao, T., Huo, M., Liu, W., Hu, T., Ma, T., Yuan, B., Zhang, M., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217157 · Cited by 20 · see citing works
An acute microglial metabolic response controls metabolism and improves memoryPreprint
Drougard, A., Ma, E. H., Wegert, V., Sheldon, R. D., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., et al. (2023) · eLife · doi:10.7554/elife.87120 · Cited by 19 · see citing works
Sood, A., Fernandes, V., Preeti, K., Rajan, S., Khatri, D. K., & Singh, S. B. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111278 · Cited by 19 · see citing works
Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity
Henn, R. E., Guo, K., Elzinga, S. E., Noureldein, M. H., Mendelson, F. E., Hayes, J. M., Rigan, D. M., Savelieff, M. G., Hur, J., & Feldman, E. L. (2023) · iScience · doi:10.1016/j.isci.2023.106164 · Cited by 18 · see citing works
Ramírez, A. E., Gil‐Jaramillo, N., Tapias, M. A., González‐Giraldo, Y., Pinzón, A. M., Rozo, P. J. P., Aristizábal-Pachón, A. F., & González, J. (2022) · Life · doi:10.3390/life12091439 · Cited by 18 · see citing works
Wang, Y., Rong, X., Guan, H., Ouyang, F., Zhou, X., Li, F., Tan, X., & Li, D. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200767 · Cited by 18 · see citing works
Palmitate Compromises C6 Astrocytic Cell Viability and Mitochondrial Function
Schmitt, L. O., Blanco, A., Lima, S. V., Mancini, G., Mendes, N. F., Latini, A., & Gaspar, J. M. (2024) · Metabolites · doi:10.3390/metabo14030161 · Cited by 18 · see citing works
Wu, Z.-S., Huang, S., & Wang, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010080 · Cited by 17 · see citing works
Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons
Michael, N. J., & Watt, M. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.045 · Cited by 16 · see citing works
Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells
Lim, Y., Kim, S., & Kim, E. (2021) · Molecular Brain · doi:10.1186/s13041-021-00777-8 · Cited by 17 · see citing works
Saipuljumri, E. N., Zeng, J., & Lo, C. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00432 · Cited by 16 · see citing works
Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons
He, W., Tran, A., Chen, C. T., Loganathan, N., Bazinet, R. P., & Belsham, D. D. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111753 · Cited by 15 · see citing works
dos Reis, L. M., Berçot, M. R., Castelucci, B. G., Martins, A. J. E., Castro, G., & Moraes‐Vieira, P. M. (2023) · Viruses · doi:10.3390/v15020525 · Cited by 15 · see citing works
Kumari, P., Fernandes, V., Sood, A., Khan, I., Khatri, D. K., & Singh, S. B. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01185-8 · Cited by 16 · see citing works
Mehboodi, M., Namdari, M. P., Abdollahi, Z., Mobarezi, Z., Kiani, M., Chamani, F., Khanbabaie, H., Rabiei, S., Maleki, M. H., Sanati, H., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107905 · Cited by 14 · see citing works
Wardelmann, K., Rath, M., Castro, J. P., Blümel, S., Schell, M., Hauffe, R., Schumacher, F., Flore, T., Ritter, K., Wernitz, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10050711 · Cited by 14 · see citing works
García-Cruz, V. M., & Arias, C. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03886-8 · Cited by 16 · see citing works
Sandri, B. J., Kim, J., Lubach, G. R., Lock, E. F., Guerrero, C. R., Higgins, L., Markowski, T. W., Kling, P. J., Georgieff, M., Coe, C. L., et al. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00235.2021 · Cited by 14 · see citing works
Cimini, F. A., Marzia Perluigi, A., Barchetta, I., Cavallo, M. G., & Barone, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105574 · Cited by 14 · see citing works
Ectopic fat accumulation in human astrocytes impairs insulin action
Heni, M., Eckstein, S. S., Schittenhelm, J., Böhm, A., Hogrefe, N., Irmler, M., Beckers, J., de Angelis, M. H., Häring, H., Fritsche, A., et al. (2020) · Royal Society Open Science · doi:10.1098/rsos.200701 · Cited by 11 · see citing works
Dierssen, M., & Barone, E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.730378 · Cited by 14 · see citing works
Vesga-Jiménez, D. J., Martín-Jiménez, C., Grismaldo, A., Aristizábal-Pachón, A. F., Pinzón, A. M., Barreto, G. E., Ramírez, D., & González, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126454 · Cited by 13 · see citing works
Extracellular vesicles released from microglia after palmitate exposure impact brain function
de Paula, G. C., Aldana, B. I., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03168-7 · Cited by 13 · see citing works
Ribeiro, R., Silva, E. G., Moreira, F., Gomes, G. F., Cussat, G. R., Silva, B. R. C., da Silva, M. C. M., Fernandes, H. D. B., Oliveira, C. D. S., Guarnieri, L. D. O., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-42955-9 · Cited by 10 · see citing works
He, W., Loganathan, N., Tran, A., & Belsham, D. D. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112179 · Cited by 12 · see citing works
Flores‐León, M., Alcaraz, N., Pérez‐Domínguez, M., Torres‐Arciga, K., Rebollar‐Vega, R., Rosa-Velázquez, I. A. D. L., Arriaga-Canon, C., Herrera, L. A., Arias, C., & González‐Barrios, R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02434-6 · Cited by 12 · see citing works
Tran, A., He, W., Chen, J. T. C., Wellhauser, L., Hopperton, K. E., Bazinet, R. P., & Belsham, D. D. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15504 · Cited by 12 · see citing works
Mechanisms Driving Palmitate-Mediated Neuronal Dysregulation in the Hypothalamus
Lieu, C. V., Loganathan, N., & Belsham, D. D. (2021) · Cells · doi:10.3390/cells10113120 · Cited by 12 · see citing works
Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy
Abdelrahman, A. A., Bunch, K. L., Sandow, P. V., Cheng, P. N.-M., Caldwell, R. B., & Caldwell, R. W. (2022) · Cells · doi:10.3390/cells11182890 · Cited by 12 · see citing works
Kim, D., Jo, Y. S., Jo, H.-S., Bae, S., Kwon, Y. W., Oh, Y., & Yoon, J. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23021006 · Cited by 11 · see citing works
Vecchiarelli, H. A., Lopes, L. T., Paolicelli, R. C., Stevens, B., Wake, H., & Tremblay, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_11 · Cited by 10 · see citing works
Lo, C. H., & Zeng, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102891 · Cited by 10 · see citing works
Blockage of Fc Gamma Receptors Alleviates Neuronal and Microglial Toxicity Induced by Palmitic Acid
Phitthayaphong, P., Kumfu, S., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210417 · Cited by 10 · see citing works
Albornoz, N., Álvarez‐Indo, J., de la Peña, A., Arias‐Muñoz, E., Coca, A., Segovia‐Miranda, F., Kerr, B., Budini, M., Criollo, A., García, M. D. L. Á., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03154-z · Cited by 9 · see citing works
Palmitic acid-induced defects in cell cycle progression and cytokinesis in Neuro-2a cells
Urso, C. J., & Zhou, H. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2040769 · Cited by 8 · see citing works
Palmitoleic acid protects microglia from palmitate-induced neurotoxicity in vitro
Yu, Q., Yang, Y., Xu, T., Cai, Y., Yang, Z., & Yuan, F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297031 · Cited by 9 · see citing works
Meta-analysis of the effects of palmitic acid on microglia activation and neurodegeneration
Zhou, H., & Chang, S. L. (2022) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2022-0008 · Cited by 9 · see citing works
Seliga, A. K., Zabłocki, K., & Bandorowicz‐Pikuła, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010254 · Cited by 8 · see citing works
McIlwraith, E. K., & Belsham, D. D. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13271 · Cited by 8 · see citing works
Heterochronic Fecal Microbiota Transfer Reverses Hallmarks of the Aging Murine Gut, Eye and BrainPreprint
Parker, A., Romano, S., Ansorge, R., Aboelnoer, A., Gall, G. L., Savva, G. M., Telatin, A., Jones, E. J., Baker, D., Rudder, S. J., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3811833 · Cited by 8 · see citing works
Role of saturated fatty acid metabolism in posttranslational modifications of the Tau protein
García-Cruz, V. M., Coria, R., & Arias, C. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05275-2 · Cited by 7 · see citing works
Gil‐Jaramillo, N., Aristizábal-Pachón, A. F., Aleman, M. A. L., Gómez, V. G., Hurtado, H. D. E., Pinto, L. C. G., Camacho, J. S. J., Rojas-Cruz, A. F., González‐Giraldo, Y., Pinzón, A. M., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1195840 · Cited by 7 · see citing works
Jäntti, M. H., Jackson, S. N., Kuhn, J. F., Parkkinen, I., Sree, S., Hinkle, J. J., Jokitalo, E., Deterding, L. J., & Harvey, B. K. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159219 · Cited by 7 · see citing works
Griffin, H., Sullivan, S. C., Barger, S. W., Phelan, K. D., & Baldini, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010629 · Cited by 7 · see citing works
Toward the Decipherment of Molecular Interactions in the Diabetic Brain
Chomová, M. (2022) · Biomedicines · doi:10.3390/biomedicines10010115 · Cited by 7 · see citing works
Molecular mechanisms underlying obesity-induced memory dysfunction: a comprehensive narrative review
Golkar, A., Razazpour, F., Dalfardi, M., & Baghcheghi, Y. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115119 · Cited by 7 · see citing works
Prenatal programing of motivated behaviors: can innate immunity prime behavior?
Montalvo-Martínez, L., Cruz-Carrillo, G., Maldonado‐Ruiz, R., Trujillo-Villarreal, L. A., Trujillo-Villarreal, L. A., & Camacho‐Morales, A. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346475 · Cited by 7 · see citing works
Antioxidant Activity of Crocodile Oil (Crocodylus siamensis) on Cognitive Function in Rats
Srisuksai, K., Parunyakul, K., Santativongchai, P., Phaonakrop, N., Roytrakul, S., Tulayakul, P., & Fungfuang, W. (2023) · Foods · doi:10.3390/foods12040791 · Cited by 6 · see citing works
An acute microglial metabolic response controls metabolism and improves memory
Drougard, A., Ma, E. H., Wegert, V., Sheldon, R. D., Panzeri, I., Vatsa, N., Apostle, S., Fagnocchi, L., Schaf, J., Gossens, K., et al. (2024) · eLife · doi:10.1101/2023.04.03.535373 · Cited by 8 · see citing works
Wang, S., Tang, C., Chen, J., Tang, H., Zhang, L., & Tang, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16513 · Cited by 6 · see citing works
RetractedFlorance, I., & Seenivasan, R. (2024) · Immunogenetics · doi:10.1007/s00251-024-01334-y · Cited by 6 · see citing works
Role of Necroptosis and Neuroinflammation in CSVD ‐Associated Cognitive Decline in db/db Mice
Wang, D., Wang, L., Zhao, P., Gu, Y., Xia, X., Li, T., An, N., & Li, X. (2025) · The FASEB Journal · doi:10.1096/fj.202500772r · Cited by 5 · see citing works
Firdous, S. M., Chakrabortty, S., Undale, V., Mallik, S., & Gouda, M. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02169-7 · Cited by 6 · see citing works
Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential
Mak, K. W. Y., Mustafa, A. F., & Belsham, D. D. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00409-5 · Cited by 5 · see citing works
de França, N. A. G., Díaz, G., Lengelé, L., Soriano, G., Caspar‐Bauguil, S., Saint‐Aubert, L., Payoux, P., Rouch, L., Vellas, B. J., Barreto, P. D. S., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad248 · Cited by 5 · see citing works
Krzystyniak, A., Głuchowska, A., Pytyś, A., Dudkowska, M., Wójtowicz, T., Targońska, A., Janiszewska, D., Sikora, E., & Mosieniak, G. (2024) · Aging · doi:10.18632/aging.206080 · Cited by 5 · see citing works
McIlwraith, E. K., & Belsham, D. D. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148367 · Cited by 5 · see citing works
Grijaldo-Alvarez, S. J. B., Alvarez, M. R., Schindler, R. L., Oloumi, A., Hernandez, N., Seales, T., Angeles, J. G. C., Nacario, R. C., Completo, G. C. J., Zivkovic, A. M., et al. (2024) · Food & Function · doi:10.1039/d4fo01598c · Cited by 5 · see citing works
Association between overweight and central interleukin‐6 in a nonclinical adult population
Enokida, T., Hattori, K., Maeda, C., 富澤, 貴., & Kunugi, H. (2024) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12488 · Cited by 5 · see citing works
Elmas, O., Cenik, P., Şirinyıldız, F., ELMAS, S., Sirin, F., & Cesur, G. (2022) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/152027/2022 · Cited by 4 · see citing works
Urrego-Morales, O., Gil-Lievana, E., Ramírez-Mejía, G., Rodríguez-Durán, L. F., Escobar, M. L., Delint-Ramírez, I., & Bermúdez-Rattoni, F. (2023) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2023.107733 · Cited by 3 · see citing works
Mustafa, A. F., He, W., & Belsham, D. D. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112411 · Cited by 3 · see citing works
The Liver-brain Axis: A Three-stage Model Linking MASLD to Cognitive Impairment and Dementia
Nie, L., Zhao, Y., Liu, W., Zhou, X., & Xia, Q. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02525-w · Cited by 3 · see citing works
Targett, I. L., Hancock, J. T., & Craig, T. J. (2026) · Biomedicines · doi:10.3390/biomedicines14051089 · Cited by 4 · see citing works
Vilela, W. R., Platt, N., Bechara, L. R. G., de Paula, G. C., Ferreira, J. C. B., de Oliveira, J., Duarte, J. M. N., & Bem, A. F. D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05455-7 · Cited by 4 · see citing works
Zhao, X., Xue, Q., Dong, L., Chu, Z., Wang, Y., Chen, C., Hu, X., Zhang, Y., & Huang, C. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06319-y · Cited by 3 · see citing works
- Authors
- Melo, H. M., Seixas da Silva, G. D. S., Sant’Ana, M. R., Teixeira, C. V. L., Clarke, J. R., Miya Coreixas, V. S., de Melo, B. C., Fortuna, J. T. S., Forny-Germano, L., Ledo, J. H., Oliveira, M. S., Figueiredo, C. P., Pardossi-Piquard, R., Checler, F., Delgado-García, J. M., Gruart, A., Velloso, L. A., Balthazar, M. L. F., Cintra, D. E., Ferreira, S. T., & De Felice, F. G.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Centre National de la Recherche Scientifique (FR)
- Universidad Pablo de Olavide (ES)
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 30
- Issue
- 7
- Pages
- 2180-2194.e8
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3007137838
- Cited by
- 140
- References
- 90
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 26 · 2023: 22 · 2022: 28 · 2021: 26 · 2020: 8
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institute for Translational Neuroscience
- Human Frontier Science Program
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Labex
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- John Simon Guggenheim Memorial Foundation
- Universidade Federal do Rio de Janeiro
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- palmitate, obesity, cerebrospinal fluid, memory impairment, TNF-α, neuroinflammation, microglial activation, astroglial activation, hippocampus, synaptic plasticity, amnestic mild cognitive impairment, intracerebroventricular infusion, anti-inflammatory therapy
- MeSH terms
- Animals, Humans, Memory Disorders, Obesity, Palmitates, Tumor Necrosis Factor-alpha, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review