Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

Chen, Michelle B., Yang, Andrew C., Yousef, Hanadie, Lee, Davis, Chen, Winnie, Schaum, Nicholas, Lehallier, Benoit, Quake, Stephen R. +1 more·2020·Cell Reports

Cited by (238)

Items 101–200 of 238

  1. Tissue-Nonspecific Alkaline Phosphatase in Central Nervous System Health and Disease: A Focus on Brain Microvascular Endothelial Cells
    Divine C. Nwafor, Allison L. Brichacek, A. Ali, Candice M. Brown · 2021 · International Journal of Molecular Sciences
  2. A high-resolution view of the heterogeneous aging endothelium
    Sarah Dobner, Fanni Tóth, Laura P. M. H. de Rooij · 2024 · Angiogenesis
  3. Inhibition of peripheral VEGF signaling rapidly reduces leucocyte obstructions in brain capillaries and increases cortical blood flow in an Alzheimer’s disease mouse model
    Muhammad Adnan Ali, Kaja Falkenhain, Brendah N. Njiru, Muhammad Murtaza-Ali, Nancy E. Ruiz‐Uribe, Mohammad Haft‐Javaherian, Stall Catchers, Nozomi Nishimura, Chris B. Schaffer, Oliver Bracko · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Getting on in Old Age: How the Gut Microbiota Interferes With Brain Innate Immunity
    Omar Mossad, Thomas Blank · 2021 · Frontiers in Cellular Neuroscience
  5. Proteome of the Luminal Surface of the Blood–Brain Barrier
    Jennifer J. Hill, Arsalan S. Haqqani, Danica B Stanimirovic · 2021 · Proteomes
  6. Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
    Steven A. Hill, Isabel Bravo‐Ferrer, Austėja Čiulkinytė, Noelia Pérez Ramos, Ilaria Rossetti, Chiara Colvin, Paula Beltran-Lobo, Carlos Parra-Pérez, Katie Emelianova, Owen Dando et al. · 2025 · Nature Communications
  7. The role of endothelial TRP channels in age-related vascular cognitive impairment and dementia
    Sharon Negri, Madison Sanford, Helen Shi, Stefano Tarantini · 2023 · Frontiers in Aging Neuroscience
  8. Influence of basal media composition on barrier fidelity within human pluripotent stem cell‐derived blood‐brain barrier models
    Emma H. Neal, Ketaki A. Katdare, Yajuan Shi, Nicholas A. Marinelli, Kameron A. Hagerla, Ethan S. Lippmann · 2021 · Journal of Neurochemistry
  9. Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus
    Sonja Fixemer, Mónica Miranda de la Maza, Gaël Paul Hammer, Félicia Jeannelle, Sophie Schreiner, Jean‐Jacques Gérardy, Susana Boluda, Dominique Mirault, Naguib Mechawar, Michel Guy André Mittelbronn et al. · 2025 · Acta Neuropathologica
  10. Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies
    Muhammad Ali, Oihane Uriarte Huarte, Tony Heurtaux, Pierre Garcia, Beatriz Pardo Rodriguez, Kamil Grzyb, Rashi Halder, Alexander Skupin, Manuel Buttini, Enrico Glaab · 2022 · Molecular Neurobiology
  11. Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial
    Patrick J. Smith, Andrew Sherwood, Alan L. Hinderliter, Stephanie Mabe, Lana L. Watkins, Linda Wilcoxon Craighead, Krista Ingle, Crystal C. Tyson, Forgive Avorgbedor, Pao‐Hwa Lin et al. · 2022 · Journal of Hypertension
  12. Molecular atlas of the human brain vasculature at the single-cell level
    Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Shigeki Takada, Hang Zhong, Samuel Suntharalingham, Sandra Vetiska, Daymé Rodrigues Rodrigues, Hubert Rehrauer, Ruilin Wu et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  13. A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer’s Disease
    Pietro Paolo Sanna, Chiara Cabrelle, Tomoya Kawamura, Daniele Mercatelli, Nathan O’Connor, Amanda J. Roberts, Vez Repunte‐Canonigo, Federico Manuel Giorgi · 2023 · eNeuro
  14. Aging and Parkinson’s disease: a complex interplay of vulnerable neurons, the immune system and the blood-brain barrier
    Jonas Bendig, Anika K. Frank, Heinz Reichmann · 2024 · Ageing and Neurodegenerative Diseases
  15. Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: A prospective observational study
    Xiao Li, Wei Cheng, Jiahui Zhang, Dongkai Li, Wang Fei, Na Cui · 2022 · Frontiers in Aging Neuroscience
  16. Molecular hallmarks of heterochronic parabiosis at single cell resolution
    Róbert Pálovics, Andreas Keller, Nicholas Schaum, Weilun Tan, Tobias Fehlmann, Michael Borja, James T. Webber, Aaron McGeever, Liana N. Bonanno, Angela Oliveira Pisco et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  17. Age-dependent transcriptional alterations in cardiac endothelial cells
    Uchenna Emechebe, Jonathan W. Nelson, Nabil J. Alkayed, Sanjiv Kaul, Andrew Adey, Anthony Paul Barnes · 2021 · Physiological Genomics
  18. The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation
    Víctor S. Tapia, Sarah E. Withers, Ran Zhou, Abigail Bennington, Christopher Hoyle, Frances Hedley, Adam El Khouja, Nadim Luka, Marco Massimo, Siobhan Crilly et al. · 2025 · Disease Models & Mechanisms
  19. From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging
    Patricia Jiménez Peinado, A. Urbach · 2023 · Cells
  20. GDF11 and aging biology - controversies resolved and pending
    Laura Ben Driss, John Lian, Ryan G. Walker, James Anthony Howard, Thomas B. Thompson, Lee L. Rubin, Amy J. Wagers, Richard Theodore Lee · 2023 · The Journal of Cardiovascular Aging
  21. Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model
    Shuo Wang, Chuangye Qi, Chetan Singh Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, Sung Hee Hwang, Bruce D. Hammock, Hongjie Li et al. · 2025 · Molecular Neurodegeneration
  22. Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice
    Rachel Britton, Angela Liu, Sanket V. Rege, Julia M. Adams, Lily Akrapongpisak, David Le, Raniel Alcantara‐Lee, Raul Estrada, Rebecca Ray, Sara Ahadi et al. · 2022 · Brain and Behavior
  23. Brain Barriers and brain fluids research in 2020 and the fluids and barriers of the CNS thematic series on advances in in vitro modeling of the blood–brain barrier and neurovascular unit
    Richard F. Keep, Hazel C. Jones, Lester R. Drewes · 2021 · Fluids and Barriers of the CNS
  24. Endothelial Cells and the Cerebral Circulation
    Theresa A. Lansdell, Laura C. Chambers, Anne McLaren Dorrance · 2022 · Comprehensive physiology
  25. Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson’s disease-like neurodegeneration
    Hélèna L. Denis, Aurélie de Rus Jacquet, Melanie Alpaugh, Michel Panisset, Roger A. Barker, Éric Boilard, Francesca Cicchetti · 2025 · Fluids and Barriers of the CNS
  26. Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
    Samantha M Schaeffer, Anthony G. Pacholko, Monica M. Santisteban, Sung Ji Ahn, Gianfranco Racchumi, Gang Wang, Laibaik Park, Giuseppe Faraco, Josef Anrather, Costantino Iadecola · 2025 · Neuron
  27. Strategies for blood–brain barrier rejuvenation and repair
    Peter C. Searson, William A. Banks · 2026 · Nature Reviews Drug Discovery
  28. Endothelial Cells and the Cerebral Circulation
    Theresa A. Lansdell, Laura C. Chambers, Anne McLaren Dorrance · 2022 · Comprehensive physiology
  29. Brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke
    Lidia García‐Bonilla, Ziasmin Shahanoor, Rose K. Sciortino, Omina Nazarzoda, Gianfranco Racchumi, Costantino Iadecola, Josef Anrather · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases
    Natalia Reglero-Real, Loïc Rolas, Sussan Nourshargh · 2025 · The Journal of Experimental Medicine
  31. Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C
    Mohammad Kasim Fatmi, Hao Wang, Lily A. Slotabec, Changhong Wen, Blaise C. Seale, Bi Zhao, Ji Li · 2024 · Aging
  32. Anesthesia/surgery leads to blood-brain barrier disruption via the transcellular and paracellular pathways, and postoperative delirium-like behavior: A comparative study in mice of different ages
    Xudong Hu, Lixia Liu, Xin Da, Si-hui Zhu, Jiawei Wang, Ming Shan, Yinuo Liu, Ziqing He, Guanghong Xu · 2024 · Experimental Neurology
  33. Brain vascular basement membrane: Comparison of human and mouse brain at the transcriptomic and proteomic levels
    Nan Zhao, Alexander F. Pessell, Tracy D. Chung, Peter C. Searson · 2025 · Matrix Biology
  34. Beyond Static Pipes: Mechanisms and In Vitro Models of Vascular Aging
    Martin W. Hetzer, Simone Bersini · 2022 · Cold Spring Harbor Perspectives in Medicine
  35. Unraveling neurovascular mysteries: the role of endothelial glycocalyx dysfunction in Alzheimer’s disease pathogenesis
    Nicholas R. O’Hare, Karina Millican, Eno Essien Ebong · 2024 · Frontiers in Physiology
  36. The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
    Jennifer Stables, Reiss Pal, Barry Matthew Bradford, Dylan Carter‐Cusack, Isis Taylor, Clare Pridans, Nemat Khan, Trent M. Woodruff, Katharine M. Irvine, KIM M. SUMMERS et al. · 2024 · Neurobiology of Disease
  37. Expression of alpha smooth muscle actin decreases with ageing and increases upon lumen obstruction in mouse brain pericytes
    Fanni Győri, Ádám Mészáros, Mónika Krecsmarik, Kinga Molnár, Cornel Baltă, Anca Oana Hermenean, Attila E. Farkas, István Adorján Krizbai, Imola Wilhelm · 2024 · GeroScience
  38. Cellular and signalling mechanisms that regulate the blood–brain barrier
    Joseph Amick, Ludmila Gordon, Chenghua Gu · 2026 · Nature Reviews Molecular Cell Biology
  39. The Provenance, Providence, and Position of Endothelial Cells in Injured Spinal Cord Vascular Pathology
    Manjeet Chopra, Ankita Bhagwani, Hemant Kumar · 2022 · Cellular and Molecular Neurobiology
  40. Pandemic of the aging society — sporadic cerebral small vessel disease
    Alexander Yuk Lun Lau, Bonaventure Yiu Ming Ip, Ho Ko, Bonnie Y. K. Lam, Lin Shi, Karen Ka Yan, Lisa Wing Chi Au, Yannie O. Y. Soo, Thomas Wai Hong Leung, Adrian Wong et al. · 2021 · Chinese Medical Journal
  41. Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice
    María Belén Rabaglino, Masaki Wakabayashi, James T. Pearson, Lars Jørn Jensen · 2021 · Mechanisms of Ageing and Development
  42. Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin
    Hao Wu, Qian Zhang, Pu Xu, Jiepeng Chen, Lili Duan, Feng Xu, Fengjiao Zhang · 2023 · Journal of Agricultural and Food Chemistry
  43. Mapping the transcriptional and epigenetic landscape of organotypic endothelial diversity in the developing and adult mouse
    Manuel E. Cantu Gutierrez, Matthew C. Hill, Gabrielle E. Largoza, William B. Gillespie, James F. Martin, Joshua D. Wythe · 2025 · Nature Cardiovascular Research
  44. Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging
    Livius V. d’Uscio, Zvonimir S. Katušić · 2021 · Aging
  45. A Brain Anti-Senescence Transcriptional Program Triggered by Hypothalamic-Derived Exosomal microRNAs
    Josefa Krarup, Lucas Araya, Felipe Álvarez, Daniel A. Bórquez, Pamela J. Urrutia · 2024 · International Journal of Molecular Sciences
  46. IQGAP2 regulates blood-brain barrier immune dynamics
    Ketaki A. Katdare, Andrew Kjar, Natasha M. O’Brown, Emma H. Neal, Alexander G. Sorets, Alena Shostak, Wilber Romero‐Fernandez, Alexander J. Kwiatkowski, Kate Mlouk, Hyosung Kim et al. · 2025 · iScience
  47. Engineering the Future of Stem Cells in Vascular Reconstruction: A Leap Towards Functional Endothelialized Tissue-Engineered Vascular Conduits
    Haïzam Oubari, Yanis Berkane, Mohamed Maxime Jeljeli, Alexandre G. Lellouch, David M. Smadja · 2025 · Stem Cell Reviews and Reports
  48. The Brain and Spinal Microvasculature in Normal Aging
    Zin Z. Khaing, Abarajithan Chandrasekaran, Anjali Katta, May J. Reed · 2023 · The Journals of Gerontology Series A
  49. Altered Topographic Distribution and Enhanced Neuronal Expression of Adenosine-Metabolizing Enzymes in Rat Hippocampus and Cortex from Early to late Adulthood
    Milorad Dragić, Andjela Stekić, Milica Zeljković, Marina Zarić Kontić, Katarina Mihajlović, Marija Adžić, Ivana Grković, Nadežda Nedeljković · 2022 · Neurochemical Research
  50. Mapping the transcriptomic changes of endothelial compartment in human hippocampus across aging and mild cognitive impairment
    Daniel V. Guebel, Néstor Vicente Torres, Ángel Acebes · 2021 · Biology Open
  51. Process-Programmed Extraction–Structure–Activity Relationships (ESAR) in edible and medicinal mushroom polysaccharides: a mechanistic and application-oriented framework
    Cunchao Zhao, Muhammad Aaqil, Rui He, Muhammad Kamil, Jingchuan Zheng, Yuwei Guo, Zhen Zhang, Taufiq Nawaz, Zhang FengLin Hai-QinCui YuanLi ChengHe Shi-JiangWang Yong-BinXiang Shao-HuaTan Bin, Lijun You et al. · 2025 · Journal of Advanced Research
  52. High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration
    Andrew John Kwok, Jianning Lu, Junzhe Huang, Bonaventure Yiu Ming Ip, Vincent Mok, H. M. Lai, Ho Ko · 2023 · Seminars in Cell and Developmental Biology
  53. Microbial and immune factors regulate brain maintenance and aging
    Laetitia Travier, Roshani Singh, Daniel Sáenz Fernández, Aleksandra Deczkowska · 2022 · Current Opinion in Neurobiology
  54. Single-cell multi-region dissection of brain vasculature in Alzheimer’s Disease
    Na Sun, Leyla Anne Akay, Mitchell H. Murdock, Yongjin Park, Adele Bubnys, Kyriaki Galani, Hansruedi Mathys, Xueqiao Jiang, Ayesha P. Ng, David Alan Bennett et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  55. Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis
    Charlotte R. Wayne, Luca Bremner, Travis E. Faust, Violeta Durán‐Laforet, Nicole Ampatey, Sarah J. Ho, Philip A. Feinberg, Panos Arvanitis, Bogoljub Ćirić, Chun‐Sheng Ruan et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Functional and multi-omic aging rejuvenation with GLP-1R agonism
    Junzhe Huang, Andrew John Kwok, Jason Chak Yan Li, Clement Lek Hin Chiu, Bonaventure Yiu Ming Ip, Lok Yi Tung, Xianyi Zheng, Hoi Tung Chow, Michelle P. S. Lo, Zhongqi Li et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier
    Quinn S. Lee, Wan Ching Chan, Shuangping Zhao, Harry M Hailemeskel, Riya Thomas, Mohsin Zafar, Fozia Mir, Péter T. Tóth, Kamran Avanaki, Leon M. Tai et al. · 2025 · Cell Reports
  58. Research progress on blood therapy for anti-aging
    Shuguang Liu, Shichun Wang, Yibo Dong, Shichao Yang, Chunyan Yao · 2025 · Journal of Advanced Research
  59. Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline
    Rebecca L. Winfree, Kevin Erreger, Jared Phillips, Mabel Seto, Yanling Wang, Julie A. Schneider, David Alan Bennett, Matthew Schrag, Timothy J. Hohman, Heidi E. Hamm · 2024 · Neurobiology of Aging
  60. Vaccine Development and Social Control: A Psychopathology of Impaired Reasoning in the Global Push for Mass Compliance
    Daniel Broudy · 2021
  61. Decreased neuronal and increased endothelial fractalkine expression are associated with neuroinflammation in Parkinson’s disease and related disorders
    Yaping Chu, Ashley S. Harms, Ashley V. Boehringer, Jeffrey H. Kordower · 2025 · Frontiers in Cellular Neuroscience
  62. Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons
    Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian · 2026 · Food Frontiers
  63. Cerebrovascular protective functions of amyloid precursor protein: Progress and therapeutic prospects
    Zvonimir S. Katušić, Livius V. d’Uscio, Tongrong He · 2025 · Pharmacology & Therapeutics
  64. Age-specific impact of type I interferons on cerebral thrombosis and inflammation
    Frederik Denorme, Izabella A. Andrianova, Mark J. Cody, Yasuhiro Kosaka, Robert A. Campbell · 2023 · Blood Advances
  65. hdWGCNA and Cellular Communication Identify Active NK Cell Subtypes in Alzheimer's Disease and Screen for Diagnostic Markers through Machine Learning
    Guobin Song, Haoyang Wu, Haiqing Chen, Shengke Zhang, Qingwen Hu, Haotian Lai, Claire Fuller, Guanhu Yang, Hao Chi · 2024 · Current Alzheimer Research
  66. Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis
    Sarah Dobner, Lisa Kleißl, Fanni Tóth, Robert L. Paxton, Irena Yordanova, Kveta Brazdilova, Cedric Vanluyten, Aleksandra Aizenshtadt, Hanna Toth, Jake Burton et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  67. A Age Related Vascular Senescence: Mystery of Blood-brain Barrier Dysfunction in Neurodegeneration
    Tapan Behl, Karthikeyan Jayabalan, Suhas Ballal, Samir Sahoo, Hanish Singh Jayasingh Chellammal, Monica Gulati, Kushi Anand, Saurabh Kumar Jha, Amin Gasmi · 2026 · Molecular Neurobiology
  68. Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status
    Roger C. McIntosh, Melissa Hidalgo, Judith D. Lobo, Kaitlyn E. Dillon, Angela Szeto, Barry E. Hurwitz · 2022 · Journal of NeuroVirology
  69. β-Estradiol 17-acetate enhances the in vitro vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery
    Sonia Guzzo, Pasquale DE BONIS, Barbara Pavan, Luciano Fadiga · 2022 · Neural Regeneration Research
  70. Optimized protocol for translatome analysis of mouse brain endothelial cells
    Namsuk Kim, Mi-Hee Jun, Jin-Young Jeong, Won‐Jong Oh · 2022 · PLoS ONE
  71. Targeted inCITE-Seq Analysis Identifies the Loss of Nuclear TDP-43 in Endothelium as a Mediator of Blood Brain Barrier Signaling Pathway Dysfunction in Neurodegeneration
    Omar M. Omar, Amy L. Kimble, Cheemala Ashok, Jordan D. Tyburski, Swati Pandey, Qian Wu, Bo Reese, Evan R. Jellison, Yunfeng Li, Bing Hao et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  72. Single-cell transcriptomics of neuroinflammation and cerebrovascular endothelial cells in the aged rat hippocampus
    Fangyan Liu, Huiqun Fu, Zhongjia Li, Yan Wu, Tianlong Wang · 2025 · iScience
  73. Autophagy–exosome crosstalk in neurodegeneration: Mechanisms and therapeutic opportunities
    Samin Sedighi, Teng Guan, Federica Michetti, Marco Cordani, Amir Barzegar Behrooz, Farzaneh Sabouni, Mehdi Eshraghi, Ayesha Saleem, Saeid Ghavami, Mohamad‐Reza Aghanoori · 2026 · Pharmacology & Therapeutics
  74. Nanoparticles as an efficient strategy to eliminate senescent brain endothelial cells
    Inês Tomé, Susana Rosa, David Sanfeliu-Redondo, Francisco José Caramelo, Anis Shahzad Khan, Peio Aristu-Zabalza, Maria Grazia Vizioli, Patrícia R. Pitrez, João Oliveira Malva, Jordi-Gracia Sancho et al. · 2026 · Journal of Controlled Release
  75. Antigen presentation at the blood–brain barrier amplifies neuroinflammation
    Sidar Aydin, Javier R. Pareja, Roland Liblau, Britta Engelhardt · 2026 · Trends in Immunology
  76. The Roads We Take: Cellular Targets and Pathways Leading Biologics Across the Blood–Brain Barrier
    Habib Baghirov · 2022 · Frontiers in Drug Delivery
  77. Aged human serum induces vascular changes in an isogenic co-culture venule model
    Tracy D. Chung, Raleigh M. Linville, Nan Zhao, Linus Wang, Zikai Xia, Peter C. Searson · 2025 · Stem Cell Reports
  78. Metabolomic profiling provides new insights into blood-brain barrier regulation
    Sheng‐Fu Huang, Omolara O. Ogunshola · 2021 · Neural Regeneration Research
  79. Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
    Md Abdul Hakim, Paulo Wagner Pires, Erik J. Behringer · 2022 · Journal of Visualized Experiments
  80. The brain vasculome
    Changhong Xing, Shuzhen Guo, Wenlu Li, Wenjun Deng, MingMing Ning, Josephine M. Lok, Ken Arai, Eng H. Lo · 2022 · Elsevier eBooks
  81. Molecular map of the human blood–brain barrier reveals links to Alzheimer’s disease
    2022 · Nature
  82. Secondary single-cell transcriptomic analysis reveals common molecular signatures of cerebrovascular injury between traumatic brain injury and aging
    Xinying Guo, Bangyan Zhang, Fernando Gómez‐Pinilla, Fan Gao, Zhen Zhao · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  83. Mapping the cellular and molecular organization of mouse cerebral aging by single-cell transcriptome imaging
    William E. Allen, Timothy R. Blosser, Zuri A. Sullivan, Catherine G. Dulac, Xiaowei Zhuang · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  84. Hypertension-Induced Neurovascular and Cognitive Dysfunction at Single-Cell Resolution
    Anthony G. Pacholko, Samantha M Schaeffer, Monica M. Santisteban, Sung Ji Ahn, Gianfranco Racchumi, Gang Wang, Laibaik Park, Giuseppe Faraco, Josef Anrather, Costantino Iadecola · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Characterizing the Microenvironment of Cerebral Arteriovenous Malformations to Test Novel Treatment Modalities
    Kavin Wazhi, Fred C. Lam, Santosh Guru, Yusuke S. Hori, Deyaldeen AbuReesh, Lorelei D. Shoemaker, David Jaehyun Park, Steven Daniel Chang · 2025 · Brain Sciences
  86. Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines
    Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian et al. · 2025 · Advanced Science
  87. Single-cell RNA sequencing reveals disease associated changes in brain endothelial cells in the 5XFAD mouse
    Rebecca Embalabala, Haley Masters, Elaina MaryElizabeth Ziehm, Jamie Pouncey, Hyosung Kim, Ethan S. Lippmann · 2026 · Fluids and Barriers of the CNS
  88. Brain microvascular endothelial cells: Beyond a barrier
    J T Ou, Ketian Hou, Yihan Fu, Yuqi Luo, Qianqian Yu, Ming Shen, Saizhi Jiang, Jianghu Zhu, Yichen Wang, Kaichen Lin et al. · 2026 · Journal of Cerebral Blood Flow & Metabolism
  89. Pericytes as key mediators of microenvironmental signaling crosstalk: implications in vascular diseases and cancer
    Qi Guo, Yujia Yao, Yueying Ding, Lushu Chen, Qiuyang Zhang, Huiying Zhang, Jinsong Xue · 2026 · Frontiers in Cell and Developmental Biology
  90. Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration
    Angélica Vega-García, Leticia Manuel Apolinar, Iris Angélica Feria-Romero, Patricia Campos‐Bedolla, Gutiérrez-García Carlos Alberto, Hiram Luna‐Munguía, Reyes-Huesca Sofía, Sandra Adela Orozco-Suárez · 2026 · Brain Sciences
  91. Angiodiversity—A tale retold by comparative transcriptomics
    Xiaowu Gu, Ondine B. Cleaver · 2022 · Elsevier eBooks
  92. A brand-new clustering method and analysis system designed for revealing the truth of the high-dimension large data deciphered the complex composition structure of human brain endothelial cells from single-cell RNA sequence data
    Boyong Wei · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  93. Engineered 3D Immuno-Glial-Neurovascular Human miBrain Model
    Li‐Huei Tsai, Alice E. Stanton, Adele Bubnys, Emre Agbas, Benjamin T. James, Dong Shin Park, Alan Y. L. Jiang, Rebecca L. Pinals, Liwang Liu, Nhat Truong et al. · 2024 · Research Square
  94. Chronic β3 adrenergic agonist treatment improves brain microvascular endothelial function and cognition in aged mice
    Natarajan Duraipandy, Shoba Ekambaram, Stefano Tarantini, Raghavendra Yelahanka Nagaraja, Andriy Yabluchanskiy, Andria F. Hedrick, Vibhudutta Awasthi, Madhan Subramanian, Anna Csiszár, Priya Balasubramanian · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  95. Ultrastructural Organization of the Honeybee Blood-Brain Barrier and Comparison with Age
    Tyler P. Quigley, Gro Vang Amdam · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  96. Blocking the VLA4/VCAM1 axis prevents infarct-induced neurodegeneration and promotes vascular integrity
    Kristy A. Zera, Karen P. Bradshaw, Li Zhu, Oliver Hahn, Aulden G. Foltz, Todd C. Peterson, Hanadie Yousef, Davis P. Lee, Elizabeth W. Mayne, Nima Aghaeepour et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  97. Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism
    Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Yiu Ming Ip, Yun Kwok Wing, H. M. Lai, Vincent Mok et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  98. Spatiotemporally Dependent Vascularization Regulates Neural Stem and Progenitor Cells
    Ken‐ichi Mizutani · 2021 · YAKUGAKU ZASSHI
  99. Mural Cells in the Brain Capillaries: Pericytes
    Ruihua Sun, Wei Li, Chenhao Gao, Jiewen Zhang, Junkui Shang · 2021 · Current Tissue Microenvironment Reports
  100. Reduction of Pericyte Coverage Leads to Blood-Brain Barrier Dysfunction Via Endothelial Transcytosis Following Chronic Cerebral Hypoperfusion
    Zhengyu Sun, Chenhao Gao, Dandan Gao, Ruihua Sun, Wei Li, Feng‐Yu Wang, Yanliang Wang, Huixia Cao, Guoyu Zhou, Jiewen Zhang et al. · 2021 · Research Square