Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Guttenplan, Kevin A., Stafford, Benjamin K., El-Danaf, Rana N., Adler, Drew I., Münch, Alexandra E., Weigel, Maya K., Huberman, Andrew D., Liddelow, Shane A.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.107776

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  87. Microglial state transitions are constrained by developmental and metabolic checkpoints
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  90. Glaucoma pathology
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  91. Transient ocular hypertension remodels astrocytes through S100B
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  97. Luci e ombre nella nuova disciplina delle aree protette
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