The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues
Open accessAbstract
Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene regulatory networks in 29 human healthy tissues using 8,279 whole-genome expression profiles from the Genotype-Tissue Expression (GTEx) project. We find sex-biased regulatory network structures in each tissue. Even though most transcription factors (TFs) are not differentially expressed between males and females, many have sex-biased regulatory targeting patterns. In each tissue, genes that are differentially targeted by TFs between the sexes are enriched for tissue-related functions and diseases. In brain tissue, for example, genes associated with Parkinson's disease and Alzheimer's disease are targeted by different sets of TFs in each sex. Our systems-based analysis identifies a repertoire of TFs that play important roles in sex-specific architecture of gene regulatory networks, and it underlines sex-specific regulatory processes in both health and disease.
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Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts
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Sex differences in brain protein expression and disease
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Metadata
- Authors
- Lopes-Ramos, C. M., Chen, C.-Y., Kuijjer, M. L., Paulson, J. N., Sonawane, A. R., Fagny, M., Platig, J., Glass, K., Quackenbush, J., & DeMeo, D. L.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 31
- Issue
- 12
- Pages
- 107795
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3037120109
- Cited by
- 445
- References
- 51
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1 d)
- Funders
- National Institute of Allergy and Infectious Diseases (5R01AI099204)
- National Cancer Institute (1R35CA220523, 1U01CA190234, 5P30CA006516, 1R35CA197449, 5P50CA127003)
- Universitetet i Oslo
- Norges Forskningsråd
- National Institutes of Health
- National Heart, Lung, and Blood Institute (K25HL133599, 5R01HL111759, 5P01HL114501, 5P01HL105339, K25HL140186)
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- Lopes-Ramos, C. M., Chen, C.-Y., Kuijjer, M. L., Paulson, J. N., Sonawane, A. R., Fagny, M., Platig, J., Glass, K., Quackenbush, J., & DeMeo, D. L. (2020). Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues. Cell Reports. https://doi.org/10.1016/j.celrep.2020.107795
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
