Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation

Augsornworawat, Punn, Maxwell, Kristina G., Velazco-Cruz, Leonardo, Millman, Jeffrey R.·2020·Cell Reports

DOI 10.1016/j.celrep.2020.108067

Cited by (206)

Items 101–200 of 206

Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
Yushan Li, Mei-Qi Xu, Jia-Li Chen, Jian-Song Huang, Jia-Ying Cao, Huajing Chen, Jiayi Zhang, Yu-Kun Luo, Ya-Zhuo Wang, Jia Sun · 2024 · Stem cell research & therapeutics
SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2
Katarzyna Błaszczyk, Anna P. Jedrzejak, Natalia Ziojla, E. G. Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam et al. · 2025 · Experimental & Molecular Medicine
Controlling Human Stem Cell‐Derived Islet Composition Using Magnetic Sorting
Allison B. Kelley, Mira Shunkarova, Marlie M. Maestas, Sarah E. Gale, Noyonika Mukherjee, Nathaniel J. Hogrebe, Jeffrey R. Millman · 2025 · Biotechnology and Bioengineering
Developing a morphomics framework to optimize implant site-specific design parameters for islet macroencapsulation devices
Barry McDermott, Scott T. Robinson, Sven A. Holcombe, Ruth E. Levey, Peter Dockery, Paul Johnson, Stewart C. Wang, Eimear B. Dolan, Garry P. Duffy · 2021 · Journal of The Royal Society Interface
Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Zhu, Han, Wang, Gaowei, Nguyen-Ngoc, Kim-Vy, Kim, Dongsu, Miller, Michael, Goss, Georgina, Kovsky, Jenna, Harrington, Austin R., Saunders, Diane, Melton, Rebecca et al. · 2022
Engineering islets from stem cells: The optimal solution for the treatment of diabetes
Du, Suya, Li, Yanjiao, Geng, Zhen, Zhang, Qi, Buhler, Leo H., Gonelle-Gispert, Carmen, Wang, Yi · 2022 · Frontiers in Immunology
Human Stem Cell Therapy for the Cure of Type 1 Diabetes Mellitus (T1D): A Hurdle Course between Lights and Shadows
Riccardo Calafiore, Giovanni Luca, Francesco Gaggia, Giuseppe Basta · 2024 · Endocrines
Construction of 3D hierarchical tissue platforms for modeling diabetes
Myungji Kim, Jinah Jang · 2021 · APL Bioengineering
Immunohistochemical Evaluation of Adaptor Protein FAM159B Expression in Normal and Neoplastic Human Tissues
Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Katja Evert, Amelie Lupp · 2021 · International Journal of Molecular Sciences
Opportunities and impediments of human pluripotent stem cell-derived islets in the treatment of diabetes
Nidheesh Dadheech, Nerea Cuesta‐Gomez, Ila Tewari Jasra, Kevin K. Verhoeff, Braulio A. Marfil‐Garza, Omar Mouhammed, Andrew M. James Shapiro · 2022 · Journal of Immunology and Regenerative Medicine
Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an INSULIN and GLUCAGON double reporter human embryonic stem cell line
Samantha Mar, Ekaterina Filatov, Cuilan Nian, Shugo Sasaki, Dahai Zhang, Francis C. Lynn · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
Anne C. Lietzke, Emily M. Walker, Elizabeth J. Bealer, Kelly M. Crumley, Jessica L. King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle A. Henry-Kanarek et al. · 2025 · Nature Communications
Reconstructing the Islets: Advances in 3D Pancreatic Organoid Models for Functional β-Cell Replacement
Muhammad Kamal Hossain, Hyung-Ryong Kim · 2026 · International Journal of Molecular Sciences
Inferring regulators of cell identity in the human adult pancreas
Lotte Vanheer, F. Fantuzzi, San-Kit To, A. Schiavo, Matthias Van Haele, Tessa Ostyn, Tine Haesen, Xiaoyuan Yi, A. Janiszewski, J. Chappell et al. · 2023 · NAR Genomics and Bioinformatics
Protocol for CRISPR-Cas12a genome editing of protein tyrosine phosphatases in human pluripotent stem cells and functional β-like cell generation
Javier Negueruela, Valerie Vandenbempt, Stephanie Talamantes, Francisco Ribeiro-Costa, Mariana Nunes, André Dias, Mayank Bansal, Esteban N. Gurzov · 2024 · STAR Protocols
Sizing up beta cells made from stem cells
Kim-Vy Nguyen-Ngoc, Matthew Wortham, Maike Sander · 2022 · Nature Biotechnology
Single-cell transcriptome lineage tracing of human pancreatic development identifies distinct developmental trajectories of alpha and beta cells
Li Lin, Yufeng Zhang, Weizhou Qian, Yao Liu, Yingkun Zhang, Fanghe Lin, Cenxi Liu, Guangxing Lu, Yanling Song, Jia Tao Song et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulations
Ji Soo Yoon, Shugo Sasaki, Jane Velghe, Katarina Zosel, Michelle Y. Y. Lee, Helena K. Winata, Cuilan Nian, Francis C. Lynn · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production in vitro and in vivo
Jeffrey C Davis, Maria Ryaboshapkina, Jennifer Hyoje-Ryu Kenty, Pınar Ö. Eser, Suraj Menon, Björn Tyrberg, Douglas A. Melton · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis
Daniel Veronese-Paniagua, Jeffrey R. Millman · 2025 · Frontiers in Endocrinology
Efficient control of enterochromaffin versus islet differentiation from human pluripotent stem cell-derived pancreatic progenitors
Paraish S. Misra, Emily C. McGaugh, Haiyang Huang, Alex Cho, Justin Lin, Farida Sarangi, Amanda Oakie, Rangarajan Sambathkumar, Youngmin Song, Valeria Fabriciova et al. · 2026 · Nature Communications
An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines
Siqin Wu, Shivam Chandel, Galyna Bryzgalova, Paschalis Efstathopoulos, Kelly Blust, Cheng Zhao, Eda Erbil, Anna Falk, My Hedhammar, Per‐Olof Berggren et al. · 2026 · Stem Cell Reports
The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice
S. Yabe, Satsuki Fukuda, Junko Nishida, Fujie Takeda, Hitoshi Okochi · 2023 · Heliyon
A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness
A. Tanaka, Minami Kosuda, Midori Yamana, Asami Furukawa, Akiko Nagasawa, M. Fujishiro, Genta Kohno, H. Ishihara · 2023 · Scientific Reports
Therapeutic potential of stem cell‐derived somatic cells to treat metabolic dysfunction‐associated steatotic liver disease and diabetes
Eduardo Hideo Gilglioni, Mayank Bansal, Wadsen St‐Pierre‐Wijckmans, Stephanie Talamantes, Alvile Kasarinaite, David C. Hay, Esteban N. Gurzov · 2025 · Obesity Reviews
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse
Ran Wei, Zhehao Du, Jue Wang, Jinlong Bi, Wencong Lyu, Haochen Wang, Jianuo He, Fanju Meng, Lijun Zhang, Chao Zhang et al. · 2025 · Protein & Cell
Adapting Physiology in Functional Human Islet Organogenesis
Eiji Yoshihara · 2022 · Frontiers in Cell and Developmental Biology
Truncated CD19 as a selection marker for the isolation of stem cell-derived β-cells
Helen Huang, Ruize Gao, Dahai Zhang, Cuilan Nian, Willem Martzke, A. M. James Shapiro, Tatsuya Kin, Yaser Tahamtani, Francis C. Lynn · 2025 · Disease Models & Mechanisms
Predicting the Key Regulators of Cell Identity in Human Adult Pancreas
Lotte Vanheer, F. Fantuzzi, San-Kit To, A. Schiavo, M. Van Haele, Tine Haesen, Xiaoyuan Yi, A. Janiszewski, J. Chappell, Adrien Rihoux et al. · 2020 · bioRxiv
Reviewer #2 (Public Review): Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro · 2024 · eLife
Limitations in PPAR⍺-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
Anne C. Lietzke, Emily M. Walker, Elizabeth J. Bealer, Kelly M. Crumley, Jessica King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle A. Henry-Kanarek et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Integrating Spatial and Single‐Nucleus Transcriptomic Data to Assess the Effects of Intrauterine Hyperglycemia on Fetal Pancreatic Development
Yu Deng, Shuting Wan, Zan Yuan, Huixia Yang · 2025 · Advanced Science
Single-cell RNA sequencing in studies of type 1 diabetes mellitus: modern state-of-the-art and technical peculiarities
Azat Vadimovich Abdullatypov, Olga Valentinovna Glushkova, Ekaterina Sergeevna Petriaikina, Viktor P. Bogdanov, D Tabakov, Vasilii Eduardovich Akimov, Vladimir Sergeevich Yudin, Anton Arturovich Keskinov, Sergey Mikhailovich Yudin, Pavel Volchkov et al. · 2025 · Frontiers in Endocrinology
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction
Xin‐Xin Yu, Xin Wang, Liu Yang, Mao‐Yang He, Xi Wang, Yining Wang, Keran Li, Cheng‐Ran Xu · 2025 · Developmental Cell
DEC1 regulates human β cell functional maturation and circadian rhythm
Sam Preza, Bliss Zheng, Zihan Gao, A. Biju, Mai Liu, Zhihui Cheng, Matthew Choi, Juan R. Alvarez-Dominguez · 2025 · Cell Reports
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation
Nathaniel J. Hogrebe, Mason D. Schmidt, Punn Augsornworawat, Sarah E. Gale, Mira Shunkarova, Jeffrey R. Millman · 2026 · Nature Communications
Generation of a pancreas derived hydrogel for the culture of hiPSC derived pancreatic endocrine cells
Constantin Berger, Markus Glaser, Anna‐Lena Ziegler, Valentina Neukel, Fabiola Walz, Daniela Zdzieblo · 2024 · Scientific Reports
Imeglimin, unlike metformin, does not perturb differentiation of human induced pluripotent stem cells towards pancreatic β‐like cells and rather enhances gain in β cell identity gene sets
Tasuku Imada, Shugo Sasaki, Hiroki Yamaguchi, Ayaka Ueda, Dan Kawamori, Naoto Katakami, Iichiro Shimomura · 2025 · Journal of Diabetes Investigation
Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation
Enrique Eduardo Sanchez-Castro, Matthew Ishahak, Tai Le, Marlie M. Maestas, Diana C. Hernandez-Rincon, Noyonika Mukherjee, Kameron Bradley, James Lu, Sarah E. Gale, Jeffrey R. Millman · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Crosstalk between the aryl hydrocarbon receptor and hypoxia-inducible factor 1α pathways in human islet models
Noa Gang, Kyle A. van Allen, William Glen Willmore, Francis C. Lynn, Jennifer E. Bruin · 2025 · Islets
Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes
Muhammad Usama, Ying Deng, Yiran Chen, Théa Milland, Mohan K. Malleshaiah, Yasaman Aghazadeh · 2025 · Frontiers in Immunology
CD133/CD49a discriminate between human pluripotent stem cell-derived pancreatic beta and alpha cells
Chenglei Tian, Yilin Di, Aisha Muhammad, Henrik Semb · 2026 · Stem Cell Reports
POLK and KCNK17 as novel candidate genes for type 2 diabetes via stress response and ion channel regulation
Yangming Qu, Yan Wang, Yulong Zhang, Hui Wu, Yan Yao · 2026 · Journal of Endocrinological Investigation
Modeling immune responses to autologous and allogeneic human stem cell–derived islet grafts in vivo
Camillo Bechi Genzano, Giorgia Zanetti, Du, Daniel Traum, Deeksha Lahori, Grant M. Downes, Sakshi Bhatele, Xiaolan Ding, Kyle D. Apley, Rebuma Firdessa-Fite et al. · 2026 · JCI Insight
Safety Issues Related to Pluripotent Stem Cell-Based Therapies: Tumour Risk
Sanne Hillenius, Joaquin Montilla‐Rojo, Thomas F. Eleveld, Daniela C. F. Salvatori, Leendert H. J. Looijenga · 2023 · Springer eBooks
In toto biological framework: Modeling interconnectedness during human development
Yosuke Yoneyama, Yunheng Wu, Kensaku Mori, Takanori Takebe · 2025 · Developmental Cell
Co-Expression of Adaptor Protein FAM159B with Different Markers for Neuroendocrine Cells: An Immunocytochemical and Immunohistochemical Study
Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Amelie Lupp · 2022 · International Journal of Molecular Sciences
Генерування інсулін-продукуючих клітин зі стовбурових клітин. Перепрограмування соматичних клітин
Mykola D. Tronko, V.M. Pushkarev, О.I. Kovzun, LIUBOV K. SOKOLOVA, VIKTOR V. PUSHKAREV · 2022 · Endokrynologia
Single Nucleus RNA Sequencing of Human Pancreatic Islets In Vitro and In Vivo Identifies New Gene Sets and Three β-Cell Subpopulations with Different Transcriptional Profile
Randy B. Kang, Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa M. Siddiq, Prashant Rajbhandari, Andrew F. Stewart, Donald K. Scott, Adolfo Garcı́a-Ocaña, Geming Lu · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Single Cell RNA-Seq Analysis of Regenerative Drug-Treated Human Pancreatic Islets Identifies A Cycling Alpha Cell Population As Key Beta Cell Progenitors
Esra Karaköse, Xuedi Wang, Peng Wang, Saul Carcamo, Deniz Demircioğlu, Luca Lambertini, Olivia Wood, Randy B. Kang, Geming Lu, Donald K. Scott et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Intraplacental injection of human iPSC-derived PDX1+ pancreatic progenitors prolongs Pdx1-deficient mice survival
Arata Wakimoto, Zeynab Javanfekr Shahri, Hyojung Jeon, Takuto Hayashi, Ching-Wei Liao, Natalia Gogoleva, Fabian Patrik Suchy, Atsushi Noda, Yuri An, Hiromitsu Nakauchi et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation
Nathaniel J. Hogrebe, Mason D. Schmidt, Punn Augsornworawat, Sarah E. Gale, Mira Shunkarova, Jeffrey R. Millman · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Endocrine-enriched stem cell-derived islets improve long-term safety in vivo
Eunike Sawitning Ayu Setyono, Nicole Katarina Rogers, Katharina Scheibner, Silvia Schirge, Hélène Reich, Michael Sterr, Timucin Öztürk, Sören Franzenburg, Väinö Lithovius, Heiko Lickert · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Modelling of Beta Cell Pathophysiology Using Stem Cell-Derived Islets
Tom Barsby, Hossam Montaser, Väinö Lithovius, Hazem Ibrahim, Eliisa Vähäkangas, Sachin Muralidharan, Vikash Chandra, Jonna Saarimäki‐Vire, Timo Otonkoski · 2023 · Springer eBooks
Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions
Kianna M. Nguyen, Quang Tuan Che, Quoc Huynh Nguyen, Kihak Gwon, Alan M. Gonzalez‐Suarez, Gulnaz Stybayeva, Robert C. Huebert, Quinn P. Peterson, Alexander Revzin · 2025 · Biomaterials Science
RNA-seq at different stages of human pancreatic β cell differentiation reveals proliferation dynamics and SMAD9 in directing β cell fate
Euodia Xi Hui Lim, G. Ong, Daniel Aron Ang, Adrian Kee Keong Teo · 2026 · Cell Death and Disease
Whole-genome CRISPR screening identifies genetic modifiers of stem cell–derived islet transplantation
Marlie M. Maestas, Kameron Bradley, Mira Shunkarova, Noyonika Mukherjee, Matthew Ishahak, James Lu, Jeffrey R. Millman · 2026 · Stem Cells Translational Medicine
Application of human induced pluripotent stem cells for tissue modeling and therapy: are we on track?
Mathew Nickel Maunu, Ingrid Meulenbelt, Y.F. Ramos · 2026 · Stem Cells
Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection
Zi-Fan Li, Yu Kang, Yu-Yu Niu · 2026 · Animal Models and Experimental Medicine
The transcription factors ISL-1 and MAFA, but not NKX6-1 Characterize a Stem-cell Derived Population of Endocrine Pancreatic Cells Capable of Controlling blood Glucose in Rodent Models of Diabetes
Jeremy J. Ratiu, Sheryl M. Southard, William L. Rust · 2023 · Medical Research Archives
Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean McCabe, Daniela Rodriguez, Alex M. Mawla, Travis S. Johnson, Michael A. Kalwat · 2025 · eLife
Greasing the machinery toward maturation of stem cell-derived β cells
Christos Karampelias, Heiko Lickert · 2024 · Cell stem cell
Epigenetic modulation of cell fate during pancreas development.
Shilpak Dilip Bele, Anthony S. Wokasch, MAUREEN A. GANNON · 2023 · PubMed
Retrieval and purification of human β cells from stem cell-derived islet engrafted mice
Jennifer H. R. Kenty, G. C. Pelayo, N. Leite · 2021 · STAR Protocols
Diabetes Mellitus and iPSC-Based Therapy
Dibyashree Chhetri, Rajesh Nanda Amarnath, Sunita Samal, Kanagaraj Palaniyandi, Dhanavathy Gnanasampanthapandian · 2023 · Springer eBooks
AT7867 promotes pancreatic progenitor differentiation of human iPSCs and accelerates diabetes reversal
Nerea Cuesta‐Gomez, Kevin K. Verhoeff, Nidheesh Dadheech, Rena L. Pawlick, Braulio A. Marfil‐Garza, Haide Razavy, Andrew M. James Shapiro · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean McCabe, Daniela Rodriguez, Alex M. Mawla, Travis S. Johnson, Michael A. Kalwat · 2024 · eLife
Multi-modal comparison of primary and stem cell-derived β-cells nominates targets for maturation
Jasmine Maghera, Cara E. Ellis, Aliya F Spigelman, Nancy P. Smith, Shugo Sasaki, Francis C. Lynn, Patrick E. MacDonald · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome
Rie Asada Kitamura, Kristina G. Maxwell, Wenjuan Ye, Kelly Kries, CRIS M. BROWN, Punn Augsornworawat, Yoel Hirsch, Martin M. Johansson, Tzvi Weiden, Joseph Ekstein et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Advances in islet organoids
Tao Yu, XinYi CHEN, Cissy Qing YU, Arial Yi ZENG · 2022 · Scientia Sinica Vitae
Novel MAFA+, ISL1+, NKX6-1-stem cell derived pancreatic cell clusters secrete insulin and control blood glucose in rodent models of diabetes
Jeremy J. Ratiu, S. Southard, Werner Rust · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Mimicking Islet Development with Human Pluripotent Stem Cells
Aubrey L. Faust, Adrian Veres, Douglas A. Melton · 2023 · Springer eBooks
Minimal SC-β-Cell Properties for Transplantation in Diabetic Patients
Veronica A. Cochrane, Yini Xiao, Hasna Maachi, Matthias Hebrok · 2023 · Springer eBooks
Genetic Regulatory Networks Guiding Islet Development
Xin‐Xin Yu, Xin Wang, Wei‐Lin Qiu, Liu Yang, Cheng‐Ran Xu · 2023 · Springer eBooks
Extracellular Matrix to Support Beta Cell Health and Function
Daniel M. Tremmel, Sara Dutton Sackett, Jon S. Odorico · 2023 · Springer eBooks
Expression of FAM159B in Humans, Rats, and Mice: A Cross-species Examination
Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Amelie Lupp · 2024 · Journal of Histochemistry & Cytochemistry
Author response: Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean McCabe, Daniela Rodriguez, Alex M. Mawla, Travis S. Johnson, Michael A. Kalwat · 2024 · eLife
Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean McCabe, Daniela Rodriguez, Alex M. Mawla, Travis S. Johnson, Michael A. Kalwat · 2024 · eLife
Reviewer #1 (Public Review): Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro · 2024 · eLife
eLife Assessment: Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Lori Sussel · 2024 · eLife
Bioengineering and omics approaches for Type 1 diabetes practical research: advancements and constraints
Xi Peng, Ling Li, Yihua Peng, Guangju Zhou, Zhenmei An · 2024 · Annals of Medicine
Exendin-4 enhances insulin-positive phenotype of human pluripotent stem cell-derived β cells during transplantation
Kelly M. Crumley, Elizabeth J. Bealer, Anne C. Lietzke, Scott A. Soleimanpour, Lonnie D. Shea · 2025 · Molecular Therapy
Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean McCabe, Daniela Rodriguez, Alex M. Mawla, Travis S. Johnson, Michael A. Kalwat · 2025 · eLife
Modeling in vivo induction of gastric insulin-secreting cells using transplanted human stomach organoids
Jiaqi Lü, Hyunkee Kim, Jian Zhu, Capucine Martin, Jiaoyue Zhang, Vasumati Polavarapu, Lauretta A. Lacko, Chaiyaboot Ariyachet, Anna Ada Dattoli, Tao Liu et al. · 2025 · Stem Cell Reports
Additional file 1 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 2 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 7 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 3 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 6 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 1 of Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles
Kang, Randy B., Yansui Li, Carolina Rosselot, Tuo Zhang, Mustafa M. Siddiq, Prashant Rajbhandari, Stewart, Andrew F., Donald K. Scott, Adolfo Garcı́a-Ocaña, Geming Lu · 2023 · Figshare
Additional file 5 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Additional file 4 of Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Mason D. Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman · 2024 · Figshare
Protective IFIH1 variant reduces immune-mediated islet stress and dysfunction in a type 1 diabetes genetic background
Daniel Veronese-Paniagua, Cameron E Banks, Kameron Bradley, Noyonika Mukherjee, Sarah E. Gale, Kate E. Hinshaw, Amy M. Meacham, Opeoluwa F Iwaloye, Hubert Ming Tse, Clayton E. Mathews et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
DBSOMA: A Machine Learning Method that Identifies Chemical Modulators of Transcriptional States Uncovers Effectors of Beta-Cell Maturation
Timothy R Kunz, José Rivera-Feliciano · 2026 · bioRxiv
Intramuscular Transplantation of Human Pluripotent Stem Cell-derived Pancreatic Endocrine Cells in Mice
Mario Hernanz, Diego Matas, Mercedes Mirasierra, Gema García, Mario Vallejo, Alberto Bartolomé · 2026 · Journal of Visualized Experiments
Single-Cell Analysis in Studying Animal Models of Metabolic Disorders
Anh-Dao Ngo, Yen-Nhi Khuong, Tien-Dat Pham, Dinh‐Toi Chu · 2026 · Springer eBooks
The Human Pancreas Cell Atlas defines a healthy reference framework for disease contextualization and translational benchmarking
Shrey Parikh, Daniel C. Strobl, Sara Jiménez, Julia Beckmann, Lucas Arnoldt, Eljas Roellin, Valerie Vandenbempt, Michael Sterr, Mandala Aije, Ha T.H. Vu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Stem Cell–Derived Islet Therapy for Type 1 Diabetes
Tom Barsby, Diego Balboa, Timo Otonkoski · 2026 · Elsevier eBooks
Type 2 diabetes mellitus limits the glucose-responsive β-like functionality but not pancreatic lineage commitment of induced human adipose-derived stem cells
Nada A. Mohamed, Amir M.H. Salem, Alaa Mohammed El-Erian, Marwa Mahmoud, Amr E. Ahmed, Walaa Gamal Hozayen, Osama Mahmoud Azmy, Nourhan Abu-Shahba · 2026 · The International Journal of Biochemistry & Cell Biology
Physical and Biochemical Determinants of Endocrine Fate in 3D Suspension Culture Based Stem Cell-Derived β-Cell Differentiation
Roberto Castro-Gutiérrez, Ali H. Shilleh, Jessie M. Barra, Shane P. M. Williams, Balachandar Nedumaran, Taylor M. Triolo, Matthias Hebrok, Holger A. Russ · 2026 · Cells