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Cited by 9Pancreatic function and diabetesPluripotent Stem Cells ResearchDiabetes and associated disorders

Engineering islets from stem cells: The optimal solution for the treatment of diabetes

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Du, Suya, Li, Yanjiao, Geng, Zhen, Zhang, Qi, Buhler, Leo H., Gonelle-Gispert, Carmen, Wang, Yi·2022·Frontiers in Immunology
DOI 10.3389/fimmu.2022.869514PMC PMC9092457
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Abstract

Diabetes is a metabolic disease characterized by insulin deficiency. Bioengineering of stem cells with the aim to restore insulin production and glucose regulation has the potential to cure diabetic patients. In this review, we focus on the recent developments for bioengineering of induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and pancreatic progenitor cells in view of generating insulin producing and glucose regulating cells for β-cell replacement therapies. Recent clinical trials using islet cells derived from stem cells have been initiated for the transplantation into diabetic patients, with crucial bottlenecks of tumorigenesis, post-transplant survival, genetic instability, and immunogenicity that should be further optimized. As a new approach given high expectations, bioengineered islets from stem cells occupies considerable potential for the future clinical application and addressing the treatment dilemma of diabetes.

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  • Transplantation of allogenic MSC-derived insulin-producing cells results in a mild allogeneic response that does not affect the cells' ability to function.

    “Empirical data has demonstrated that the transplantation of allogenic MSC-derived insulin-producing cells results in a mild allogeneic response that does not affect the cells’ ability to function.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [121]

    The ‘MSCs and Islet Co-transplantation for Islet Function Protection’ section (page unavailable) discusses MSCs transplanted alongside islets, not allogeneic transplantation of MSC-derived insulin-producing cells. A search for MSC-derived insulin-producing cells and a mild allogeneic response found no passage assessing whether such a response leaves those cells functional. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Du, S., Li, Y., Geng, Z., Zhang, Q., Buhler, L. H., Gonelle-Gispert, C., & Wang, Y.
Affiliations
University of Electronic Science and Technology of China (CN)
Corresponding author
Wang, Yi
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2022-04-27
Volume
13
Pages
869514-869514
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2022.869514
PMC
PMC9092457
OpenAlex
W4285740945
Cited by
9
References
5
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 2
FWCI
0.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81802504)
  • Chengdu Science and Technology Bureau (2021-YF05-00225-SN)
  • Health Commission of Sichuan Province
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
stem cell-derived islets, diabetes mellitus, beta cell replacement therapy, induced pluripotent stem cells, mesenchymal stem cells, embryonic stem cells, pancreatic progenitor cells, insulin production, glucose regulation, islet transplantation, carcinogenesis, immunogenicity, genomic instability, clinical trials
MeSH terms
Cell Differentiation, Diabetes Mellitus, Glucose, Humans, Insulin, Islets of Langerhans Transplantation, Embryonic Stem Cells

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