Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease

Rosario, Dorines, Bidkhori, Gholamreza, Lee, Sunjae, Bedarf, Janis, Hildebrand, Falk, Le Chatelier, Emmanuelle, Uhlen, Mathias, Ehrlich, Stanislav Dusko, Proctor, Gordon, Wüllner, Ullrich, Mardinoglu, Adil, Shoaie, Saeed·2021·Cell Reports

Cited by (168)

Items 101–168 of 168

  1. Deciphering the causal link between gut microbiota and membranous nephropathy: insights into potential inflammatory mechanisms
    Jianbo Qing, Changqun Li, Nan Jiao · 2025 · Renal Failure
  2. Homocysteine induced N6-methyldeoxyadenosine modification perturbation elicits mitochondria dysfunction contributes to the impairment of learning and memory ability caused by early life stress in rats
    Ling Zhang, Fang Xi Xie, Xue Wang, Zhaowei Sun, Yuhan Wu, Zhaoxin Sun, Shijia Zhang, Xiaobing Chen, Yun Zhao, Lingjia Qian · 2025 · Redox Biology
  3. Prophylactic effects of sialylated glycopeptides from edible bird’s nest on neuroinflammation in lipopolysaccharide-treated mice via the gut-brain axis
    Xiang‐Rong Cheng, Chenxi Zhang, Xiaoyi Zhao, Qiushi Li, Song Yu, Lan Zhang, Jiahui Ma, Yuyao Chen, Man Yuan, Dongliang Wang · 2024 · Food Science and Human Wellness
  4. Effects of dietary fiber on the composition, function, and symbiotic interactions of intestinal microbiota in pre-weaned calves
    Wentao Lu, Yi Xia, YuHan Ge, Xinyue Zhang, Kaidi Shen, Haohua Zhuang, Zhaoju Deng, Dengke Liu, Jie Cao, Chong Ma · 2025 · Frontiers in Microbiology
  5. Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study
    Po-Chun Liu, Shao-Ying Cheng, Chih-Chi Li, Yu-Ke Wang, Yufeng Jane Tseng, Ming‐Che Kuo · 2025 · Frontiers in Neuroscience
  6. Microbial diversity in drug-naïve Parkinson’s disease patients
    Eliša Papić, Valentino Rački, Mario Hero, Ana Nyasha Zimani, Mojca Čižek Sajko, Gloria Rožmarić, Nada Starčević Čizmarević, Saša Ostojić, Miljenko Kapović, Goran Hauser et al. · 2025 · PLoS ONE
  7. The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision
    Yibin Wang, Labapuchi Labapuchi, Meiqing Liu, Linxi Chen · 2025 · Journal of Advanced Research
  8. Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives
    Ruoxi Wang, Ali Afzal, Xiao-Yuan Jing, Yu Zhou, Jin-xing Feng, Zuxin Chen, Dezhi Cao, Xin‐an Liu · 2026 · Acta Pharmacologica Sinica
  9. A Proanthocyanidins-Rich Cili (Rosa roxburghii) Fruit Extract Protects CCl4-Induced Mouse Hepatic Fibrosis via Modulation of Ferroptosis and Gut Microbiota
    Yang Liu, Jingzhong Zheng, Xin Zheng, Dan Zhou, Hang Ma, Xue Zhou, Fahuan Ge · 2025 · Nutrients
  10. Genetic homocysteine risk shapes cardiocerebral structure and multimorbidity through age- and sex-specific mechanisms: a UK Biobank study
    Chenjie Feng, Yupeng Ma, Tian Zhang, Peng Zhang, Yu Xia Zhao · 2025 · Frontiers in Nutrition
  11. Arabinoxylan ameliorates memory deficits and amyloid pathology in male 5 × FAD mice via modulation of gut microbiota structure
    Kai Hu, C. Li, Yuxiang Liu, Changxu Pan, Peijun Xie, Lu Wen, Haotian Xu, Yue Tang, Peng Zheng, Yu Huang · 2025 · Neuroscience
  12. Integrated multi-cohort analysis of the Parkinson’s disease gut metagenome
    Joseph C. Boktor, Gil Sharon, Leo Verhagen Metman, Deborah A. Hall, Phillip A. Engen, Zoe J. Zreloff, Daniel Hakim, John W. Bostick, James A. Ousey, Danielle Lange et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis
    Joshua D. Elford, Elise Jasmijn Heesbeen, Nienke A. van der Plaats, Johan Garssen, Aletta D. Kraneveld, Lucianne Groenink, Paula Perez‐Pardo · 2026 · npj Parkinson s Disease
  14. Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development
    Shoulong Xu, Yanjiao Huang, Chenyue Hu, Wenli Ding, Zhenwei Pu, Qiang Li, Zhiliang Xu · 2026 · Comprehensive physiology
  15. A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications
    Raunak Khanduja, Richard E. Frye · 2026 · International Journal of Molecular Sciences
  16. Mechanisms of multi-organ damage in Wilson disease from the gut-liver-brain axis perspective: copper metabolism, gut microbiota, and metabolite communication
    Xue-Qiao Wang, Yanxin Wang, Zhao-Hao Ye, Zhilin Zhang, Si-Fan Cen · 2026 · Frontiers in Microbiology
  17. Immunology and microbiome: Implications for motor systems
    Yasamin Mahjoub, Davide Martino · 2023 · Handbook of clinical neurology
  18. A Mendelian Randomization Study: Roles of Gut Microbiota in Sepsis – Who is the Angle?
    Yeping Bian, Jian Xu, Xiaojing Deng, Suming Zhou · 2024 · Polish Journal of Microbiology
  19. High salt diet alleviates disease severity in native experimental autoimmune uveitis
    Naomi Derluyn, Vincent Foucart, Marko Verce, Rami Abdo, Louis Vaudoisey, Deborah A. Lipski, Véronique Flamand, Amandine Everard, Catherine Bruyns, François Willermain · 2024 · Frontiers in Ophthalmology
  20. Interspecific variation in gut microbiome diversity across the Etosha National Park herbivore community
    Rylee Jensen, Erin A. McKenney, James C. Beasley, Claudine C. Cloete, Madeline H. Melton, Diana J. R. Lafferty · 2025 · PLoS ONE
  21. Metabolomic Changes in Idiopathic and GBA1 Parkinson’s Disease
    Caitlin Walton‐Doyle, Elisa Menozzi, Anthony H.V. Schapira, Perdita E. Barran · 2025 · medRxiv
  22. Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
    Т. А. Короленко, Alexander B. Pupyshev, В. М. Беличенко, Maria A. Tikhonova, Tamara G. Amstislavskaya · 2023 · Neurochemical Journal
  23. Probiotic Lactiplantibacillus plantarum Probio87 Improves Gut Microbial Profiles in HPV‐Positive Women: A Randomized, Placebo‐Controlled and Double‐Blind Study
    Pei Xu, Mageswaran Uma Mageswary, Azka Ainun Nisaa, Sarah Binti Samsudin, Nurul Izza Binti Mohamed Rusdi, Abigail Rembui Jerip, Chern Ein Oon, Salina Binti Sany, Cheng Siang Tan, Zhenhua Zhu et al. · 2025 · Molecular Nutrition & Food Research
  24. Could sleep deprivation and changes in maternal microbiota during early pregnancy raise the risk of neural tube and heart malformations?
    Vanessa Cavalcante‐Silva, Marise Samama, Allan Chiaratti de Oliveira, Vânia D’Almeida, Frida Entezami, Sérgio Tufik, Mônica L. Andersen · 2025 · Medical Hypotheses
  25. Bile Acid Dysregulation in Parkinson’s Disease: Longitudinal Changes and Altered Metabolic Interactions
    Andrea Izarik Verespejova, Marián Grendár, Martin Kertys, Natalia Hunarova, Li Sheng Chien, Milan Grofik, Michaela Škorvanová, Jakub Šofránko, Nela Žideková, Egon Kurča et al. · 2026 · Biomolecules
  26. Zusammenhänge zwischen Mikrobiom und Neurodegeneration
    Corinna Bang, Sebastian Heinzel · 2023 · Der Nervenarzt
  27. The Intake of Dietary Lipids Improves Glucose Tolerance via Modulating Gut Microbiota
    Yuri Haneishi, Saya WATANABE, Ayana OKADA, Hitoshi Takemae, Deborah Bastoni, Lucia Treppiccione, Anella Saggese, Tetsuya Mizutani, Mauro Rossi, Junki Miyamoto · 2024 · Journal of Nutritional Science and Vitaminology
  28. Multi-omics analysis highlights the link of aging-related cognitive decline with systemic inflammation and alterations of tissue-maintenance
    Stefano Flor, Thomas Dost, Madlen Haase, Rowena Simon, Simone Ederer, A. Samer Kadibalban, Jan Taubenheim, Maja Olecka, Alesia Walker, Johannes Zimmermann et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Transient Colonising Microbes Promote Gut Dysbiosis and Disease Pathology
    Sunjae Lee, Victoria Meslier, Gholamreza Bidkhori, Lucie Etienne‐Mesmin, Junseok Park, Florian Plaza Oñate, Haizhuang Cai, Emmanuelle Le Chatelier, Nicolas Pons, Doheon Lee et al. · 2022 · SSRN Electronic Journal
  30. A genome-scale metabolic model of Drosophila melanogaster for integrative analysis of brain diseases
    Müberra Fatma Cesur, Kiran Raosaheb Patil, Tunahan Çakır · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  31. The gut microbiome modulates the transformation of microglial subtypes
    Peng Xie, Yu Ting Huang, Jing Wu, Hanping Zhang, Yifan Li, Lu Wen, Xun Tan, Ke Cheng, Yiyun Liu, Juncai Pu et al. · 2022 · Research Square
  32. Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization
    Jack Jansma, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles P. van Wezel, Pieter Van den Abbeele, Saskia van Hemert, Sahar El Aidy · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Microbiote et mode d’action du méthotrexate dans la polyarthrite rhumatoïde
    Jean‐Marie Berthelot, Frédéric Lioté, Jean Sibilia · 2023 · Revue du Rhumatisme
  34. Microbiota as a ‘black swan’: The extrange case of bacterial amyloids and neurodegeneration
    Rafael Giraldo · 2024 · Anales de la Real Academia Nacional de Farmacia
  35. Some Advanced Biomarkers of Neurodegenerative Disorders: Focus on Cystatin C
    Т. А. Короленко, Alexander B. Pupyshev, В. М. Беличенко, Maria A. Tikhonova, Tamara G. Amstislavskaya · 2023 · Нейрохимия
  36. La transplantation de microbiote fécal dans la maladie de Parkinson
    Mathilde d'Esneval, Mayté Castro Jiménez, Ines Debove, Selma Aybek, Vanessa Fleury · 2024 · Forum Médical Suisse ‒ Swiss Medical Forum
  37. Fäkale Mikrobiota-Transplantation bei Morbus Parkinson
    Mathilde d'Esneval, Mayté Castro Jiménez, Ines Debove, Selma Aybek, Vanessa Fleury · 2024 · Swiss Medical Forum ‒ Schweizerisches Medizin-Forum
  38. Dietary fibre supplementation promotes symbiotic interactions among the intestinal microbiota in preweaning calves
    Wentao Lu, Yi Xia, YuHan Ge, Xinyue Zhang, Kaidi Shen, Haohua Zhuang, Zhaoju Deng, Dengke Liu, Jie Cao, Chong Ma · 2024 · Research Square
  39. Biomarkers in Parkinson’s Disease
    Hao Deng, Tianbai Li, Xinyao Liu, Yaping Shao, Zhaofei Yang, Song Li, Weidong Le · 2025 · Cambridge University Press eBooks
  40. Meta-analysis of postbiotics on evaluating health benefits and mechanisms
    Kaliyan Barathikannan, Ramachandran Chelliah, Host Antony David, Edvina Princy Kulandairaj, Selvakumar Vijayalakshmi, Momna Rubab, Deog-Hwan Oh · 2025 · Elsevier eBooks
  41. Homocysteine Induced N6-Methyldeoxyadenosine Modification Perturbation Elicits Mitochondria Dysfunction Contributes to the Impairment of Learning and Memory Ability Caused by Early Life Stress in Rats
    Yun Fu Zhao, Ling Zhang, Fang Xi Xie, Xue Wang, Zhaowei Sun, Yuhan Wu, Zhaoxin Sun, Shijia Zhang, Xiaobing Chen, Lingjia Qian · 2025 · SSRN Electronic Journal
  42. Gut Microbiota-Mediated Modulation of Neurodevelopmental Behavior in CLCN4- Deficient Mice
    Yura Choi, Shambhunath Bose, Jihong Oh, Eun‐Ji Song, Young‐Do Nam, Songhee Jeon, Hojun Kim · 2025 · Research Square
  43. Leveraging the salivary microbiome profile to stratify REM sleep behavior disorder and synucleinopathies
    Daisuke Hisamatsu, Hiroaki Masuoka, Haruka Takeshige‐Amano, Taku Hatano, Takashi Ogawa, Kazuo Yamashiro, Rina Kurokawa, Yo Mabuchi, Yuna Naraoka, Takashi Asada et al. · 2026 · npj Biofilms and Microbiomes
  44. Additional file 3 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  45. Additional file 2 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  46. Additional file 4 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  47. The Gut-Brain Axis: The effect of dysbiosis on mood disorders like anxiety and depression
    Mirra Sangal · 2022 · Journal of High School Science
  48. Additional file 3 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  49. Additional file 1 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  50. Additional file 4 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  51. Additional file 8 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, Liangliang He, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  52. Additional file 5 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  53. Additional file 6 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  54. Additional file 2 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  55. Additional file 7 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, Liangliang He, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  56. Additional file 5 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, He, Liangliang, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  57. Additional file 1 of Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations
    Palni Kundra, Annelies Geirnaert, Pugin, Benoit, Serafina Plüss, Susanna Kariluoto, Christophe Lacroix, Anna Greppi · 2024 · Figshare
  58. Additional file 6 of Gut dysbiosis induces the development of depression-like behavior through abnormal synapse pruning in microglia-mediated by complement C3
    Wenzhi Hao, Ma, Qingyu, Wang, Lu, Naijun Yuan, Hua Tian Gan, Liangliang He, Li, Xiaojuan, Huang, Junqing, Jiaxu Chen · 2024 · Figshare
  59. Étude du neurodéveloppement et de l'infertilité masculine chez différents modèles murins de Trisomie 21
    Rodolphe Dard · 2024 · theses.fr (ABES)
  60. Isolation of folate-producing probiotics and its regulatory effects on homocysteine metabolism and gut microbiota composition
    Mingfang Pan, Changming YE, Yun Song, Minqing Tian, Runming Wang, Ping Chen · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Gut Microbiome Changing Foods and Nutrition
    Raja Shekhar Nunavath, Krishnaveni Nagappan, Bhadram Kalyan Chekraverthy · 2026 · Springer eBooks
  62. Integrative multi-omics analysis reveals host–microbiome metabolic alterations and candidate biomarkers in Parkinson’s disease
    Qiang Zhao, ShuJia Zuo, Sufang Liu, Juan Wang, Jie Tang, Xuanxuan Zou, Yahui Leng, Xianhong Li, Min Zhou, Jing Tian et al. · 2026 · BMC Microbiology
  63. Association of probiotic medication use with incident Parkinson disease and alzheimer disease: a nationwide nested case–control study
    Yasutaka Ihara, Noriyuki Miyaue, Miho Ihara, Tomohisa Kurata, Masahiro Nagai · 2026 · Journal of Neurology
  64. Omics research in Parkinson’s disease: evolution, integrated analysis, pathogenic mechanisms, biomarkers, and therapeutic targets
    Ruizhe Cao, Xue Bai, Huan Zhong · 2026 · Frontiers in Molecular Neuroscience
  65. Gut Microbiome in Depression with and without REM Sleep Behavior Disorder
    Yuhua Yang, Ningning Li, Li Zhou, Siyi Gong, Zhixuan He, Shi Tang, Jianzhang Ni, Yaping Liu, Joey Wing Yan Chan, Brian P. N. Or et al. · 2026 · Molecular Psychiatry
  66. Perillaldehyde alleviates Parkinson's disease via the gut microbiota-5-methyltetrahydrofolate–homocysteine methylation axis
    Xiyu Gao, Aohan Yan, Yifei Wang, Juxiong Liu, Dianfeng Liu, Giuqiu Hu, Haolong Zhang, Shoupeng Fu, Dewei He · 2026 · Phytomedicine
  67. Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling
    Dan Wang, Dong Zhou, Jianguo Gu, Chao Huang, Wenting Zhang · 2026 · Gut Microbes
  68. Deciphering the heterogeneity of prodromal α-synucleinopathy: linking brain biotyping and gut dysbiosis in isolated REM sleep behaviour disorder
    Shi Tang, Yuhua Yang, Yanlin Wang, Siyi Gong, Ningning Li, Zhixuan He, Jianzhang Ni, Jing Wang, Yaping Liu, Joey Wing Yan Chan et al. · 2026 · EBioMedicine