Systematic Analysis of Gut Microbiome Reveals the Role of Bacterial Folate and Homocysteine Metabolism in Parkinson’s Disease
Open accessAbstract
Parkinson's disease (PD) is the most common progressive neurological disorder compromising motor functions. However, nonmotor symptoms, such as gastrointestinal (GI) dysfunction, precede those affecting movement. Evidence of an early involvement of the GI tract and enteric nervous system highlights the need for better understanding of the role of gut microbiota in GI complications in PD. Here, we investigate the gut microbiome of patients with PD using metagenomics and serum metabolomics. We integrate these data using metabolic modeling and construct an integrative correlation network giving insight into key microbial species linked with disease severity, GI dysfunction, and age of patients with PD. Functional analysis reveals an increased microbial capability to degrade mucin and host glycans in PD. Personalized community-level metabolic modeling reveals the microbial contribution to folate deficiency and hyperhomocysteinemia observed in patients with PD. The metabolic modeling approach could be applied to uncover gut microbial metabolic contributions to PD pathophysiology.
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Because of dysbiosis, lipid, amino acid and energy metabolism are often dysregulated in Parkinson's disease patients.
“because of dysbiosis, lipid, amino acid and energy metabolism are often dysregulated in PD patients [96,97,98,99,100]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [99]
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- Authors
- Rosario, D., Bidkhori, G., Lee, S., Bedarf, J., Hildebrand, F., Le Chatelier, E., Uhlen, M., Ehrlich, S. D., Proctor, G., Wüllner, U., Mardinoglu, A., & Shoaie, S.
- Affiliations
- King's College London (GB)
- Norwich Research Park (GB)
- Université Paris-Saclay (FR)
- University Hospital Bonn (DE)
- Corresponding author
- Shoaie, Saeed
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 34
- Issue
- 9
- Pages
- 108807
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W3133979860
- Cited by
- 167
- References
- 75
- Citations by year
- 2026: 16 · 2025: 36 · 2024: 45 · 2023: 33 · 2022: 34 · 2021: 3
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion, other-oa)
- DZNE Pub (submittedVersion, cc-by)
- Funders
- SciLifeLab
- Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- Parkinson's disease, gut microbiota, folate metabolism, homocysteine metabolism, hyperhomocysteinemia, folate deficiency, gastrointestinal dysfunction, mucin degradation, glycans, correlation networks, non-motor symptoms, disease severity
- MeSH terms
- Gastrointestinal Microbiome, Aged, Bacteria, Folic Acid, Folic Acid Deficiency, Homocysteine, Humans, Intestines, Male, Middle Aged, Mucins, Parkinson Disease, Polysaccharides, Severity of Illness Index, Case-Control Studies, Hyperhomocysteinemia, Databases, Genetic, Metagenome, Metabolomics, Metabolome, Metagenomics, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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