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Cited by 42Hypothalamic control of reproductive hormonesSexual Differentiation and DisordersEstrogen and related hormone effects

Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior

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Parikh, Roma, Sorek, Eschar, Parikh, Shivang, Michael, Keren, Bikovski, Lior, Tshori, Sagi, Shefer, Galit, Mingelgreen, Shira +25 more·2021·Cell Reports
DOI 10.1016/j.celrep.2021.109579PMC PMC8411113
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Abstract

Ultraviolet (UV) light affects endocrinological and behavioral aspects of sexuality via an unknown mechanism. Here we discover that ultraviolet B (UVB) exposure enhances the levels of sex-steroid hormones and sexual behavior, which are mediated by the skin. In female mice, UVB exposure increases hypothalamus-pituitary-gonadal axis hormone levels, resulting in larger ovaries; extends estrus days; and increases anti-Mullerian hormone (AMH) expression. UVB exposure also enhances the sexual responsiveness and attractiveness of females and male-female interactions. Conditional knockout of p53 specifically in skin keratinocytes abolishes the effects of UVB. Thus, UVB triggers a skin-brain-gonadal axis through skin p53 activation. In humans, solar exposure enhances romantic passion in both genders and aggressiveness in men, as seen in analysis of individual questionaries, and positively correlates with testosterone level. Our findings suggest opportunities for treatment of sex-steroid-related dysfunctions.

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  • Several studies showed improved self-reported sexual satisfaction and PLS scale scores after light therapy with ultraviolet B radiation exposure.

    “Nevertheless, several studies showed improved self-reported sexual satisfaction and PLS scale scores after light therapy with ultraviolet B radiation exposure, suggesting benefits for libido and sexual well-being.[35][36]”

    From A systematic appraisal of emerging alternative therapies in men’s health and wellness (2025) · cites this paper as [35]

    The Results section ('UVB treatment induces romantic passion in humans') reports higher scores on some Passionate Love Scale items after UVB phototherapy, though attraction declined in male participants. The Discussion explicitly says the questionnaire measured romantic rather than physiological or sexual passion; this study does not establish improved self-reported sexual satisfaction. (LLM, conf=0.90)

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Authors
Parikh, R., Sorek, E., Parikh, S., Michael, K., Bikovski, L., Tshori, S., Shefer, G., Mingelgreen, S., Zornitzki, T., Knobler, H., Chodick, G., Mardamshina, M., Boonman, A., Kronfeld-Schor, N., Bar-Joseph, H., Ben-Yosef, D., Amir, H., Pavlovsky, M., Matz, H., Ben-Dov, T., Golan, T., Nizri, E., Liber, D., Liel, Y., Brenner, R., Gepner, Y., Karnieli-Miller, O., Hemi, R., Shalgi, R., Kimchi, T., Percik, R., Weller, A., & Levy, C.
Affiliations
  • Tel Aviv University (IL)
  • The Max Stern Yezreel Valley College (IL)
  • Hebrew University of Jerusalem (IL)
  • Kaplan Medical Center (IL)
  • Sheba Medical Center (IL)
  • Tel Aviv Sourasky Medical Center (IL)
  • Ono Academic College (IL)
  • Ben-Gurion University of the Negev (IL)
  • Wolfson Medical Center (IL)
  • Weizmann Institute of Science (IL)
  • Bar-Ilan University (IL)
Corresponding author
Levy, Carmit
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-08
Volume
36
Issue
8
Pages
109579
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2021.109579
PMC
PMC8411113
OpenAlex
W3194558202
Cited by
42
References
8
Citations by year
2026: 7 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 6
FWCI
5.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Hebrew University of Jerusalem
  • Israel Science Foundation (1781/16, 2017/20)
  • Tel Aviv University
  • Horizon 2020 Framework Programme
  • Ministry of Science and Technology, Israel (3-13608, 84/19)
  • Horizon 2020
  • European Research Council (726225)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
UVB exposure, sexual behavior, sex hormones, hypothalamic-pituitary-gonadal axis, p53, keratinocytes, anti-Müllerian hormone, estrus, romantic passion, testosterone, sun exposure
MeSH terms
Animals, Estrus, Female, Hypothalamo-Hypophyseal System, Male, Ovary, Sexual Behavior, Skin, Testosterone, Ultraviolet Rays, Keratinocytes, Mice, Anti-Mullerian Hormone, Gene Knockout Techniques

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