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Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

Berghoff, Stefan A., Spieth, Lena, Sun, Ting, Hosang, Leon, Depp, Constanze, Sasmita, Andrew O., Vasileva, Martina H., Scholz, Patricia, Zhao, Yu, Krueger-Burg, Dilja, Wichert, Sven, Brown, Euan R., Michail, Kyriakos, Nave, Klaus-Armin, Bonn, Stefan, Odoardi, Francesca, Rossner, Moritz, Ischebeck, Till, Edgar, Julia M., Saher, Gesine·2021·Cell Reports
DOI 10.1016/j.celrep.2021.109889

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Figure 2 Expression of genes related to cholesterol metabolism in neurons of genetic and experimental myelin disease models (A) Fluorescence-directed laser microdissection of EYFPnuc + CPNs from the primary motor and somatosensory cortex (yellow line) of PLP-KO and CNP-KO mutants (scale bar: 200 m m). Insets show the tissue section before and after laser microdissection and isolated neurons (scale bars: 20 m m).
Figure 2 Expression of genes related to cholesterol metabolism in neurons of genetic and experimental myelin disease models (A) Fluorescence-directed laser microdissection of EYFPnuc + CPNs from the primary motor and somatosensory cortex (yellow line) of PLP-KO and CNP-KO mutants (scale bar: 200 m m). Insets show the tissue section before and after laser microdissection and isolated neurons (scale bars: 20 m m).CC-BY-NC-ND · From the PDF
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Cholesterol synthesis and metabolism gene expression in neurons, oligodendrocytes and astrocytes from human MS snRNA-seq datasets Neurons Oligodendrocytes Astrocytes
Cholesterol synthesis and metabolism gene expression in neurons, oligodendrocytes and astrocytes from human MS snRNA-seq datasets Neurons Oligodendrocytes AstrocytesCC-BY-NC-ND · From the PDF
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Research works printed but not linked: 41

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Metadata

Authors
Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Depp, C., Sasmita, A. O., Vasileva, M. H., Scholz, P., Zhao, Y., Krueger-Burg, D., Wichert, S., Brown, E. R., Michail, K., Nave, K.-A., Bonn, S., Odoardi, F., Rossner, M., Ischebeck, T., Edgar, J. M., & Saher, G.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-10
Volume
37
Issue
4
Pages
109889
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.109889
Cited by
76
References
14
Language
en
Licence
Funders
  • Alzheimer Forschung Initiative e V (19070)
  • Wilhelm Sander Foundation (2019.138.1)
  • Doctor Miriam and Sheldon G Adelson Medical Research Foundation
  • Multiple Sclerosis Society (127)
  • Medical Research Scotland (791-2014)
  • Deutsche Forschungsgemeinschaft (SA 2014/2-1)

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