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Cited by 9Fish biology, ecology, and behaviorNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Neural readout of a latency code in the active electrosensory system

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Perks, Krista E., Sawtell, Nathaniel B.·2022·Cell Reports
DOI 10.1016/j.celrep.2022.110605PMC PMC9045710

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Abstract

The latency of spikes relative to a stimulus conveys sensory information across modalities. However, in most cases, it remains unclear whether and how such latency codes are utilized by postsynaptic neurons. In the active electrosensory system of mormyrid fish, a latency code for stimulus amplitude in electroreceptor afferent nerve fibers (EAs) is hypothesized to be read out by a central reference provided by motor corollary discharge (CD). Here, we demonstrate that CD enhances sensory responses in postsynaptic granular cells of the electrosensory lobe but is not required for reading out EA input. Instead, diverse latency and spike count tuning across the EA population give rise to graded information about stimulus amplitude that can be read out by standard integration of converging excitatory synaptic inputs. Inhibitory control over the temporal window of integration renders two granular cell subclasses differentially sensitive to information derived from relative spike latency versus spike count.

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  • The amplitude of the first negative peak of the LFP was used as a proxy for the activity of individual electroreceptor afferent nerve fibers.

    “Based on previous results, we used the amplitude of the first negative peak of the LFP (henceforth called the LFP amplitude) as a proxy for the activity of individual electroreceptor afferent nerve fibers [18, 19, 20].”

    From An end-to-end model of active electrosensation (2024) · cites this paper as [18]

    The Results section, “Comparing ELL zones,” says the early negative field-potential component reflects excitation evoked by electroreceptor afferents and discusses its amplitude. It explains amplitude grading as summed input from a local population of afferents, however, not as a proxy for the activity of individual fibers. No page number is provided in our copy. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Perks, K. E., & Sawtell, N. B.
Affiliations
  • Wesleyan University (US)
  • Mortimer B. Zuckerman Mind Brain Behavior Institute (US)
Corresponding author
Sawtell, Nathaniel B.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2022-03
Volume
38
Issue
13
Pages
110605
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2022.110605
PMC
PMC9045710
OpenAlex
W4220804731
Cited by
9
References
3
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2
FWCI
1.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by-nc-nd)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
Funders
  • National Institute of Neurological Disorders and Stroke (NS075023, NS118448)
  • National Science Foundation Division of Integrative Organismal Systems (IOS-1656354)
  • National Science Foundation
  • Irma T. Hirschl Trust
  • National Institutes of Health
Topics
  • Physical Sciences › Environmental Science › Nature and Landscape Conservation › Fish biology, ecology, and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
spike latency, spike number, mormyrid fish, electroreceptors, granular cells
MeSH terms
Animals, Electric Fish, Electric Organ, Synaptic Transmission, Neurons

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