Cited by 121Pain Management and Opioid UseOpioid Use Disorder TreatmentPharmaceutical Practices and Patient Outcomes

The Role of Opioid Analgesics in Geriatric Pain Management

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Naples, Jennifer Greene, Gellad, Walid F., Hanlon, Joseph T.·2016·Clinics in Geriatric Medicine

Abstract

When possible, chronic noncancer pain (CNCP) in older adults should be managed by nonpharmacologic modalities in conjunction with nonopioid analgesics. If moderate-to-severe pain persists despite these approaches, however, nonparenteral opioids may be considered as adjunctive therapy. This article reviews the epidemiology of opioid use and their effectiveness for CNCP in older adults and summarizes important age-related changes in opioid pharmacokinetics and pharmacodynamics that increase the risks of adverse effects in the elderly. Finally, to assist clinicians with selecting appropriate therapy, the article concludes with an evidence-based approach to optimize opioid prescribing in older adults with CNCP.

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Crossref · 10.1016/j.cger.2016.06.006

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Authors
Naples, J. G., Gellad, W. F., & Hanlon, J. T.
Affiliations
University of Pittsburgh (US)
Corresponding author
Hanlon, Joseph T.
Venue
Clinics in Geriatric Medicine
Publisher
Elsevier BV
Published
2016-11
Volume
32
Issue
4
Pages
725-735
ISSN
0749-0690 (ISSN-L)
OpenAlex
W2495724511
Cited by
121
References
54
Citations by year
2026: 5 · 2025: 13 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 23 · 2020: 19 · 2019: 18 · 2018: 9 · 2017: 5 · 2016: 1
FWCI
2.06
Type
journal article
Language
en
Open access
Locations
  • Clinics in Geriatric Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (T32-AG021885, R01AG037451, P30AG024827)
  • Health Services Research and Development (1 I01 HX001765, IIR 12-379, I01 HX001765)
  • Agency for Healthcare Research and Quality (R18 HS023779)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
opioid analgesics, geriatric pain management, chronic non-cancer pain, older adults, opioid pharmacokinetics, opioid pharmacodynamics, opioid prescribing, non-pharmacological pain management, non-opioid analgesics, age-related changes
MeSH terms
Aged, Analgesics, Opioid, Dose-Response Relationship, Drug, Humans, Treatment Outcome, Chronic Pain

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