The Role of Opioid Analgesics in Geriatric Pain Management
Open accessAbstract
When possible, chronic noncancer pain (CNCP) in older adults should be managed by nonpharmacologic modalities in conjunction with nonopioid analgesics. If moderate-to-severe pain persists despite these approaches, however, nonparenteral opioids may be considered as adjunctive therapy. This article reviews the epidemiology of opioid use and their effectiveness for CNCP in older adults and summarizes important age-related changes in opioid pharmacokinetics and pharmacodynamics that increase the risks of adverse effects in the elderly. Finally, to assist clinicians with selecting appropriate therapy, the article concludes with an evidence-based approach to optimize opioid prescribing in older adults with CNCP.
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Aging can decrease the clearance of pain medications from the body and increase the risk of adverse drug events, especially in older adults undergoing polypharmacy.
“Aging can decrease the clearance of pain medications from the body and increase the risk of adverse drug events, especially in older adults undergoing polypharmacy [8].”
From Voice Assistant Reminders and the Latency of Scheduled Medication Use in Older Adults With Pain: Descriptive Feasibility Study (2021) · cites this paper as [8]
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- Authors
- Naples, J. G., Gellad, W. F., & Hanlon, J. T.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Hanlon, Joseph T.
- Venue
- Clinics in Geriatric Medicine
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 32
- Issue
- 4
- Pages
- 725-735
- ISSN
- 0749-0690 (ISSN-L)
- PMC
- PMC5139620
- OpenAlex
- W2495724511
- Cited by
- 121
- References
- 54
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 9 · 2023: 9 · 2022: 10 · 2021: 23 · 2020: 19 · 2019: 18 · 2018: 9 · 2017: 5 · 2016: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinics in Geriatric Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (T32-AG021885, R01AG037451, P30AG024827)
- Health Services Research and Development (1 I01 HX001765, IIR 12-379, I01 HX001765)
- Agency for Healthcare Research and Quality (R18 HS023779)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- opioid analgesics, geriatric pain management, chronic non-cancer pain, older adults, opioid pharmacokinetics, opioid pharmacodynamics, opioid prescribing, non-pharmacological pain management, non-opioid analgesics, age-related changes
- MeSH terms
- Aged, Analgesics, Opioid, Dose-Response Relationship, Drug, Humans, Treatment Outcome, Chronic Pain
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