CoChat
Sign Up
Cited by 202Venous Thromboembolism Diagnosis and ManagementAbdominal vascular conditions and treatmentsLiver Disease and Transplantation

The DOI matches its Crossref record; 21 of the 23 references it cites were found in a registry or an index.

Survival and Recurrence in Patients With Splanchnic Vein Thromboses

Open access
Thatipelli, Mallikarjun R., McBane, Robert D., Hodge, David O., Wysokinski, Waldemar E.·2010·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2009.09.019
Open this paper in CoChat — free accountOpen PDF

Abstract

Background & aims Hepatic, splenic, portal, and mesenteric veins are confluent elements within the splanchnic system. It is therefore unclear whether thromboses of isolated segments represent unique entities. We compared etiologies, recurrence, and survival of patients with thromboses of different splanchnic venous segments. Methods An inception cohort of individuals was identified with first lifetime incident of splanchnic vein thrombosis between 1980 and 2000. We performed a case-controlled comparison of recurrent thrombosis and survival data with those of patients with deep venous thrombosis (DVT). Results The study (832 patients; mean age, 53 +/- 17 years; 42% women) included patients with isolated portal (n = 329), mesenteric (n = 76), splenic (n = 62), and hepatic (n = 45) vein thrombosis and patients with multisegment involvement (n = 320). Malignancy (27%) and cirrhosis (24%) were the most common etiologies. Recurrence-free survival 10 years after splanchnic vein thrombosis (76%) was comparable with that after DVT (68%) and not improved by anticoagulant therapy. Hormone therapy was the only independent predictor of recurrence (hazard ratio [HR], 2.2; 95% confidence interval [CI], 1.09-4.45; P = .03). Major bleeding was 6.9/100 patient-years. Gastroesophageal varices (HR, 2.63; 95% CI, 1.72-4.03; P < .001) and warfarin therapy (HR, 1.91, 95% CI, 1.25-2.92; P = .003) were independent predictors of bleeding. The 10-year survival rate of patients with splanchnic vein thrombosis (60%) was lower than that of patients with DVT (68%, P < .05). Older age (HR, 1.03; 95% CI, 1.02-1.03), active cancer (HR, 2.23; 95% CI, 1.78-2.78), and myeloproliferative disorder (HR, 1.92; 95% CI, 1.41-2.61) were independent determinants of mortality (P < .001). Conclusions Splanchnic vein thrombosis depends on the pathology of the organ supplied. On the basis of the low rate of recurrence and substantial rate of major hemorrhage, prolonged anticoagulant therapy does not appear to be justified.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2009.09.019

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 23 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Thatipelli, M. R., McBane, R. D., Hodge, D. O., & Wysokinski, W. E.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2010-02
Volume
8
Issue
2
Pages
200-205
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2009.09.019
OpenAlex
W2031156548
Cited by
201
References
23
Citations by year
2026: 8 · 2025: 9 · 2024: 15 · 2023: 16 · 2022: 13 · 2021: 11 · 2020: 17 · 2019: 5 · 2018: 15 · 2017: 16 · 2016: 13 · 2015: 16 · 2014: 16 · 2013: 15 · 2012: 7
FWCI
4.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords
splanchnic vein thrombosis, portal vein thrombosis, mesenteric vein thrombosis, splenic vein thrombosis, hepatic vein thrombosis, recurrent thrombosis, survival, deep vein thrombosis, hormone therapy, major bleeding, gastroesophageal varices, warfarin, anticoagulation, myeloproliferative neoplasms
MeSH terms
Adult, Aged, Anticoagulants, Female, Hepatic Veins, Humans, Male, Mesenteric Veins, Middle Aged, Portal Vein, Recurrence, Splenic Vein, Thrombosis, Survival Analysis, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review