Do Not Assume Symptoms Indicate Failure of Anti–Tumor Necrosis Factor Therapy in Crohn's Disease
Abstract
It is a challenge to monitor patients with Crohn's disease who remain symptomatic despite anti-tumor necrosis factor therapy. Clinicians must use a systematic approach for each patient and obtain objective evidence about disease activity and response to therapy. Alternate etiologies for symptoms should be sought and treated, if found. Active Crohn's disease despite therapy requires reassessment and adjustments to management plans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many patients and providers do not want further escalation of inflammatory bowel disease-specific therapy when minimal inflammatory disease is observed.
“many patients and providers do not want further escalation of IBD-specific therapy if minimal inflammatory disease is observed.5”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [5]
A functional etiology is an explanatory mechanism for residual symptoms in inflammatory bowel disease patients who respond to tricyclic antidepressants.
“A functional etiology is an explanatory mechanism for residual symptoms in IBD patients responsive to TCAs.5”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [5]
Occult inflammation represents another mechanistic explanation for residual symptoms in inflammatory bowel disease patients without structural abnormalities.
“Occult inflammation represents another mechanistic explanation for residual symptoms in IBD patients without structural abnormalities.5”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [5]
Cites
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
Hanauer, S. B., Feagan, B. G., Lichtenstein, G. R., Mayer, L., Schreiber, S., Colombel, J., Rachmilewitz, D., Wolf, D. C., Olson, A. D., Bao, W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08512-4 · Cited by 4,164 · see citing works
Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease
Colombel, J., Sandborn, W. J., Reinisch, W., Mantzaris, G. J., Kornbluth, A. A., Rachmilewitz, D., Lichtiger, S., D’Haens, G., Diamond, R. H., Broussard, D. L., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0904492 · Cited by 3,140 · see citing works
Self-citationInfluence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease
Baert, F., Noman, M., Vermeire, S., Assche, G. V., Haens, G. D., Carbonez, A., & Rutgeerts, P. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020888 · Cited by 2,012 · see citing works
Long-Term Evolution of Disease Behavior of Crohn's Disease
Cosnes, J., Cattan, S., Blain, A., Beaugerie, L., Carbonnel, F., Parc, R., & Gendre, J. (2002) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200207000-00002 · Cited by 1,345 · see citing works
Risk Factors for Opportunistic Infections in Patients With Inflammatory Bowel Disease
Törüner, M., Loftus, E. V., Harmsen, W. S., Zinsmeister, A. R., Orenstein, R., Sandborn, W. J., Colombel, J., & Egan, L. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.012 · Cited by 1,014 · see citing works
Self-citationAdalimumab Induction Therapy for Crohn Disease Previously Treated with Infliximab
Sandborn, W. J., Rutgeerts, P. J., Enns, R., Hanauer, S. B., Colombel, J., Panaccione, R., D’Haens, G., Li, J., Rosenfeld, M. R., Kent, J. D., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00159 · Cited by 961 · see citing works
Self-citationComparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease
Rutgeerts, P. J., Feagan, B. G., Lichtenstein, G. R., Mayer, L., Schreiber, S., Colombel, J., Rachmilewitz, D., Wolf, D. C., Olson, A. D., Bao, W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.014 · Cited by 942 · see citing works
Thia, K. T. J., Sandborn, W. J., Harmsen, W. S., Zinsmeister, A. R., & Loftus, E. V. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.070 · Cited by 793 · see citing works
Self-citationClinical, biological, and endoscopic picture of attacks of Crohn's disease
Modigliani, R., Mary, J.-Y., Simon, J.-F., Cortot, A., Soule, J.-C., Gendre, J.-P., & Rene, E. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90002-i · Cited by 699 · see citing works
Maser, E. A., Villela, R., Silverberg, M. S., & Greenberg, G. R. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.06.025 · Cited by 613 · see citing works
Infliximab Prevents Crohn's Disease Recurrence After Ileal Resection
Regueiro, M. D., Schraut, W. H., Baidoo, L., Kip, K. E., Sepulveda, A. R., Pesci, M., Harrison, J., & Plevy, S. E. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.051 · Cited by 598 · see citing works
Impact of Clostridium difficile on Inflammatory Bowel Disease
Issa, M., Vijayapal, A., Graham, M. B., Beaulieu, D. B., Otterson, M. F., Lundeen, S. J., Skaros, S., Weber, L. R., KOMOROWSKI, R. A., Knox, J. F., et al. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.028 · Cited by 570 · see citing works
Rutgeerts, P. J., Diamond, R. H., BALA, M. M., Olson, A. D., Lichtenstein, G. R., Bao, W., Patel, K., Wolf, D. C., Safdi, M. A., Colombel, J., et al. (2006) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.08.011 · Cited by 547 · see citing works
Afif, W., Loftus, E. V., Faubion, W. A., et al. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.9 · Cited by 486 · see citing works
Hanauer, S. B., Korelitz, B. I., Rutgeerts, P. J., Peppercorn, M. A., Thisted, R. A., Cohen, R. D., & Present, D. H. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.002 · Cited by 458 · see citing works
Jones, J., Loftus, E. V., Panaccione, R., Chen, L., Peterson, S. E., McConnell, J. P., Baudhuin, L. M., Hanson, K., Feagan, B. G., Harmsen, S. W., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.06.010 · Cited by 414 · see citing works
Self-citationFeagan, B. G., Panaccione, R., Sandborn, W. J., D’Haens, G., Schreiber, S., Rutgeerts, P. J., Loftus, E. V., Lomax, K. G., Yu, A. P., Wu, E. Q., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.069 · Cited by 372 · see citing works
Self-citationThe Risk of Retention of the Capsule Endoscope in Patients with Known or Suspected Crohn's Disease
Cheifetz, A. S., Kornbluth, A. A., Legnani, P. E., Schmelkin, I. J., Brown, A., Lichtiger, S., & Lewis, B. S. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00761.x · Cited by 365 · see citing works
PERSOONS, P., VERMEIRE, S., DEMYTTENAERE, K., FISCHLER, B., VANDENBERGHE, J., VAN OUDENHOVE, L., PIERIK, M., HLAVATY, T., VAN ASSCHE, G., NOMAN, M., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02535.x · Cited by 253 · see citing works
Minderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243 · see citing works
Sandborn, W. J., Abreu, M. T., D’Haens, G., et al. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.04.021 · Cited by 152 · see citing works
Self-citationCytomegalovirus infection in patients with inflammatory bowel disease
Vega, R. (1999) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00068-4 · Cited by 146 · see citing works
Bruining, D. H., Siddiki, H. A., Fletcher, J. G., et al. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20529 · Cited by 138 · see citing works
Self-citationAntibiotic treatment of small bowel bacterial overgrowth in patients with Crohn's disease
Castiglione, F., Rispo, A., Girolamo, E. D., Cozzolino, A., Manguso, F., Grassia, R., & Mazzacca, G. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01800.x · Cited by 119 · see citing works
Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease
Kim, J. J., Simpson, N., Klipfel, N. E., et al. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1126-4 · Cited by 119 · see citing works
Allez, M., Vermeire, S. A. R. A., Mozziconacci, N., et al. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04130.x · Cited by 113 · see citing works
Use of the Given® Patency System for the screening of patients at high risk for capsule retention
Signorelli, C., Rondonotti, E., Villa, F., et al. (2006) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.01.010 · Cited by 99 · see citing works
Colombel, J., Sandborn, W. J., Rutgeerts, P. J., Kamm, M. A., Yu, A. P., Wu, E. Q., Pollack, P. F., Lomax, K. G., Chao, J., & Mulani, P. M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.59 · Cited by 92 · see citing works
Self-citationConsequences of immunogenicity to the therapeutic monoclonal antibodies ReoPro and Remicade.
Wagner, C. L., Schantz, A., Barnathan, E. S., et al. (2003) · PubMed · Cited by 85 · see citing works
Sandborn, W. J., Colombel, J., Schreiber, S., Plevy, S. E., Pollack, P. F., Robinson, A. M., Chao, J., & Mulani, P. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21328 · Cited by 80 · see citing works
Self-citationUsing CT Enterography to Monitor Crohn's Disease Activity: A Preliminary Study
Hara, A. K., Alam, S., Heigh, R. I., et al. (2008) · American Journal of Roentgenology · doi:10.2214/ajr.07.2877 · Cited by 74 · see citing works
Sandborn, W. J., Schreiber, S., Hanauer, S. B., et al. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.03.024 · Cited by 65 · see citing works
Self-citationClassification of the sequelae of bowel resection for Crohn's disease
Cosnes, J., de Parades, V., Carbonnel, F., et al. (1994) · British journal of surgery · doi:10.1002/bjs.1800811122 · Cited by 41 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Converging goals of treatment of inflammatory bowel disease from clinical trials and practice
Levesque, B. G., Sandborn, W. J., Ruel, J., Feagan, B. G., Sands, B. E., & Colombel, J.-F. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.08.003 · Cited by 217 · see citing works
Self-citationTricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
- Authors
- Bruining, D. H., & Sandborn, W. J.
- Affiliations
- Mayo Clinic (US)
- University of California San Diego (US)
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 9
- Issue
- 5
- Pages
- 395-399
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2105797118
- Cited by
- 20
- References
- 33
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, anti-tumor necrosis factor therapy, treatment failure, disease activity monitoring, treatment reassessment, inflammatory bowel disease management
- MeSH terms
- Crohn Disease, Humans, Immunologic Factors, Tumor Necrosis Factor-alpha, Treatment Outcome, Drug Monitoring
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
