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Cited by 257Gastrointestinal motility and disordersPelvic floor disorders treatmentsCongenital gastrointestinal and neural anomalies

The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.

Oral Bisacodyl Is Effective and Well-Tolerated in Patients With Chronic Constipation

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Kamm, Michael A., Mueller–Lissner, Stefan, Wald, Arnold, Richter, Erika, Swallow, Ros, Gessner, Ulrika·2011·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2011.03.026
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Abstract

Background & aims Although stimulant laxatives have been used for many years to treat patients with constipation, their clinical value has been questioned, and there have been few high-quality trials to assess their efficacy. We tested the efficacy and safety of 4 weeks of treatment with oral bisacodyl tablets in patients with chronic constipation, defined by Rome III criteria.Methods This randomized, double-blind, placebo-controlled, parallel-group study was conducted in 27 centers in the United Kingdom. After a 2-week baseline period without study medication, patients were randomly assigned, in a 2:1 ratio, to groups that were given 10 mg bisacodyl (n = 247) or placebo (n = 121), once daily, for 4 weeks. Patients used an electronic diary each day to record information relating to their constipation.Results The mean (± standard error of the mean [SEM]) number of complete spontaneous bowel movements (CSBMs) per week during the treatment period increased from 1.1 ± 0.1 in both groups to 5.2 ± 0.3 in the bisacodyl group and 1.9 ± 0.3 in the placebo group (P < .0001). All secondary end points (number of complete spontaneous bowel movements for each single week, number of spontaneous bowel movement (SBMs), and constipation-associated symptoms) differed significantly between groups, demonstrating efficacy for bisacodyl (P < .0001). Compared with baseline, there was a statistically significant improvement in the overall Patient Assessment of Constipation quality of life (PAC-QOL) score and all subscales (satisfaction, physical discomfort, psychosocial discomfort, worries and concerns) in the bisacodyl-treated patients, compared with those that received placebo (P ≤ .0070). Treatment with bisacodyl was well-tolerated.Conclusions Oral bisacodyl is an effective and well-tolerated treatment for patients with chronic constipation. It improves bowel function, constipation-related symptoms, and disease-related QOL.

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  1. Eoff, 2008, Optimal treatment of chronic constipation in managed care: review and round table discussion, J Manag Care Pharm, 14, 1
  2. Friedrich, 2009, Measurements of bisacodyl and sodium picosulfate in breast milk of healthy postpartum women, Gut, 58, A330

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Metadata

Authors
Kamm, M. A., Mueller–Lissner, S., Wald, A., Richter, E., Swallow, R., & Gessner, U.
Affiliations
  • The University of Melbourne (AU)
  • University of Wisconsin–Madison (US)
  • Boehringer Ingelheim (Germany) (DE)
  • Boehringer Ingelheim (United Kingdom) (GB)
Corresponding author
Gessner, Ulrika
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2011-07
Volume
9
Issue
7
Pages
577-583
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2011.03.026
OpenAlex
W2138857851
Cited by
257
References
19
Citations by year
2026: 4 · 2025: 1 · 2024: 14 · 2023: 21 · 2022: 10 · 2021: 29 · 2020: 77 · 2019: 11 · 2018: 15 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 7
FWCI
10.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords
bisacodyl, chronic constipation, stimulant laxatives, stool frequency, quality of life, drug tolerability, Rome III criteria
MeSH terms
Administration, Oral, Adult, Aged, Bisacodyl, Cathartics, Chronic Disease, Constipation, Double-Blind Method, Female, United Kingdom, Humans, Male, Middle Aged, Placebos, Treatment Outcome

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