The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Oral Bisacodyl Is Effective and Well-Tolerated in Patients With Chronic Constipation
Open accessAbstract
Background & aims Although stimulant laxatives have been used for many years to treat patients with constipation, their clinical value has been questioned, and there have been few high-quality trials to assess their efficacy. We tested the efficacy and safety of 4 weeks of treatment with oral bisacodyl tablets in patients with chronic constipation, defined by Rome III criteria.Methods This randomized, double-blind, placebo-controlled, parallel-group study was conducted in 27 centers in the United Kingdom. After a 2-week baseline period without study medication, patients were randomly assigned, in a 2:1 ratio, to groups that were given 10 mg bisacodyl (n = 247) or placebo (n = 121), once daily, for 4 weeks. Patients used an electronic diary each day to record information relating to their constipation.Results The mean (± standard error of the mean [SEM]) number of complete spontaneous bowel movements (CSBMs) per week during the treatment period increased from 1.1 ± 0.1 in both groups to 5.2 ± 0.3 in the bisacodyl group and 1.9 ± 0.3 in the placebo group (P < .0001). All secondary end points (number of complete spontaneous bowel movements for each single week, number of spontaneous bowel movement (SBMs), and constipation-associated symptoms) differed significantly between groups, demonstrating efficacy for bisacodyl (P < .0001). Compared with baseline, there was a statistically significant improvement in the overall Patient Assessment of Constipation quality of life (PAC-QOL) score and all subscales (satisfaction, physical discomfort, psychosocial discomfort, worries and concerns) in the bisacodyl-treated patients, compared with those that received placebo (P ≤ .0070). Treatment with bisacodyl was well-tolerated.Conclusions Oral bisacodyl is an effective and well-tolerated treatment for patients with chronic constipation. It improves bowel function, constipation-related symptoms, and disease-related QOL.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Based on meta-analyzed data from 2 studies, SPS likely leads to a large increase in CSBMs per week (MD 2.54, 95% CI 1.07-4.01) and SBMs per week (MD 4.04, 95% CI 2.37-5.71) and improved the consistency of stool on the Bristol Stool Form Scale 53 (MD 2.4 points higher, 95% CI 2.07-2.73) and PAC-QOL scores (MD 0.65, 95% CI 0.50-0.80) compared with placebo.”
From American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation (2023) · cites this paper as [51]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For bisacodyl at the initial starting dose of 10 mg compared with placebo, diarrhea occurred in 53.4% vs 1.7%, respectively, while abdominal pain occurred in 24.7% vs 2.5%, respectively. 51”
From American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation (2023) · cites this paper as [51]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Stool form scale as a useful guide to intestinal transit time
Lewis, S. J., & Heaton, K. W. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709011203 · Cited by 3,244
Myths and Misconceptions About Chronic Constipation
Müller-Lissner, S. A., Kamm, M. A., Scarpignato, C., & Wald, A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40885.x · Cited by 616
Self-citationEfficacy and Safety of Traditional Medical Therapies for Chronic Constipation: Systematic Review
Ramkumar, D. P., & Rao, S. S. C. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40925.x · Cited by 497
Systematic Review on the Management of Chronic Constipation in North America
Brandt, L. J., Prather, C. M., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.50613_2.x · Cited by 344
An Evidence-Based Approach to the Management of Chronic Constipation in North America
American College of Gastroenterology Chronic Constipation Task Force (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.50613_1.x · Cited by 247
Mueller-Lissner, S., Kamm, M. A., Wald, A., Hinkel, U., Koehler, U., Richter, E., & Bubeck, J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.41 · Cited by 218
Self-citationKamm, M. A., Müller-Lissner, S. A., Talley, N. J., Tack, J. F., Boeckxstaens, G. E., Minushkin, O. N., Калинин, А. А., Dzieniszewski, J., van der Haeck, P. W. E., Fordham, F., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40749.x · Cited by 193
Self-citationLactulose syrup assessed in a double-blind study of elderly constipated patients
SANDERS, J. F. (1978) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1978.tb01967.x · Cited by 109
Kienzle-Horn, S., VIX, J. ‐., Schuijt, C., Peil, H., Jordan, C., & Kamm, M. A. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02903.x · Cited by 91
Self-citationEffects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers
Manabe, N., Cremonini, F., Camilleri, M., Sandborn, W. J., & Burton, D. D. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04118.x · Cited by 89
Clinical trial guidelines for pharmacological treatment of irritable bowel syndrome
Corazziari, E., Bytzer, P., Delvaux, M., Holtmann, G., Malagelada, J. R., Morris, J., Muller‐Lissner, S., Spiller, R. C., Tack, J., & Whorwell, P. J. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01709.x · Cited by 80
Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation
Kienzle-Horn, S., Vix, J.-M., Schuijt, C., Peil, H., Jordan, C., & Kamm, M. A. (2007) · Current Medical Research and Opinion · doi:10.1185/030079907x178865 · Cited by 65
Self-citationSystematic Review on the Management of Chronic Constipation in North America
Brandt, L. J., Prather, C. M., Quigley, E. M. M., Schiller, L. R., Schoenfeld, P., & Talley, N. J. (2005) · The American Journal of Gastroenterology · doi:10.14309/00000434-200507001-00002 · Cited by 63
Ewe, K., & H�lker, B. (1974) · Journal of Molecular Medicine · doi:10.1007/bf01468863 · Cited by 50
Jauch, R., Hankwitz, R., Beschke, K., & Pelzer, H. (1975) · PubMed · Cited by 47
Gulseth, M. P., Sobieszczyk, P. S., Fanikos, J. R., & Seifert, R. D. (2008) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2008.14.s6-a.1 · Cited by 29
Roth, W., & Beschke, K. (1988) · PubMed · Cited by 23
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Eoff, 2008, Optimal treatment of chronic constipation in managed care: review and round table discussion, J Manag Care Pharm, 14, 1
- Friedrich, 2009, Measurements of bisacodyl and sodium picosulfate in breast milk of healthy postpartum women, Gut, 58, A330
Cited by
Sorted by citations
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866
Irritable bowel syndrome: a clinical review.
Chey, W., Kurlander, J. E., & Eswaran, S. (2015) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2015.0954 · Cited by 748
Mechanisms, evaluation, and management of chronic constipation
Bharucha, A. E., & Lacy, B. E. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.034 · Cited by 655
Ford, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E., Spiegel, B. M. R., & Quigley, E. M. M. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.187 · Cited by 664
An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation
Aziz, I., Whitehead, W. E., Palsson, O. S., Törnblom, H., & Simrén, M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1708718 · Cited by 413
Metadata
- Authors
- Kamm, M. A., Mueller–Lissner, S., Wald, A., Richter, E., Swallow, R., & Gessner, U.
- Affiliations
- The University of Melbourne (AU)
- University of Wisconsin–Madison (US)
- Boehringer Ingelheim (Germany) (DE)
- Boehringer Ingelheim (United Kingdom) (GB)
- Corresponding author
- Gessner, Ulrika
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 9
- Issue
- 7
- Pages
- 577-583
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W2138857851
- Cited by
- 257
- References
- 19
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 14 · 2023: 21 · 2022: 10 · 2021: 29 · 2020: 77 · 2019: 11 · 2018: 15 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 7
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- bisacodyl, chronic constipation, stimulant laxatives, stool frequency, quality of life, drug tolerability, Rome III criteria
- MeSH terms
- Administration, Oral, Adult, Aged, Bisacodyl, Cathartics, Chronic Disease, Constipation, Double-Blind Method, Female, United Kingdom, Humans, Male, Middle Aged, Placebos, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
