Mechanisms, evaluation, and management of chronic constipation

Bowel Disorders

Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866 · see citing works

Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018

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Epidemiology of constipation in children and adults: A systematic review

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Simplified assessment of segmental colonic transit

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American Gastroenterological Association Technical Review on Constipation

Bharucha, A. E., Pembérton, J. H., & Locke, G. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.028 · Cited by 914 · see citing works

Functional anorectal disorders.

Bharucha, A., Wald, A., Enck, P., & Rao, S. S. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.064 · Cited by 770 · see citing works

Defecography in normal volunteers: results and implications.

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Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis

Ford, A. C., Quigley, E. M. M., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E. E., Spiegel, B. M. R., & Moayyedi, P. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.202 · Cited by 747 · see citing works

Myths and Misconceptions About Chronic Constipation

Müller-Lissner, S. A., Kamm, M. A., Scarpignato, C., & Wald, A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40885.x · Cited by 616 · see citing works

Sphincter denervation in anorectal incontinence and rectal prolapse.

Parks, A. G., Swash, M., & Urich, H. (1977) · Gut · doi:10.1136/gut.18.8.656 · Cited by 552 · see citing works

Biofeedback Is Superior to Laxatives for Normal Transit Constipation Due to Pelvic Floor Dyssynergia

Chiarioni, G., Whitehead, W. E., Pezza, V., Morelli, A., & Bassotti, G. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.014 · Cited by 460 · see citing works

An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking

Paré, P., Ferrazzi, S., Thompson, W., Irvine, E. J., & Rance, L. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.05259.x · Cited by 445 · see citing works

Anismus in chronic constipation

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Decreased interstitial cell of Cajal volume in patients with slow-transit constipation

He, C., Burgart, L. J., Wang, L., Pembérton, J. H., Young‐Fadok, T. M., Szurszewski, J. H., & Farrugia, G. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70409-4 · Cited by 407 · see citing works

Severe chronic constipation of young women: 'idiopathic slow transit constipation'.

Preston, D. M., & Lennard‐Jones, J. E. (1986) · Gut · doi:10.1136/gut.27.1.41 · Cited by 402 · see citing works

Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation

Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396 · see citing works

Randomized Controlled Trial of Biofeedback, Sham Feedback, and Standard Therapy for Dyssynergic Defecation

Rao, S. S. C., Seaton, K. K., Miller, M. J., Brown, K., Nygaard, I., Stumbo, P., Zimmerman, B., & Schulze, K. S. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.12.023 · Cited by 387 · see citing works

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

Rao, S. S. C., Lembo, A. J., Shiff, S. J., Lavins, B. J., Currie, M. G., Jia, X. D., Shi, K., MacDougall, J. E., Shao, J. Z., Eng, P., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.255 · Cited by 383 · see citing works

Interstitial cells of Cajal in health and disease

Farrugia, G. (2008) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2008.01109.x · Cited by 380 · see citing works

Biofeedback Benefits Only Patients With Outlet Dysfunction, Not Patients With Isolated Slow Transit Constipation

Chiarioni, G., Salandini, L., & Whitehead, W. E. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.015 · Cited by 378 · see citing works

Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis

Ford, A. C., & Suares, N. C. (2011) · Gut · doi:10.1136/gut.2010.227132 · Cited by 378 · see citing works

Childhood constipation: longitudinal follow-up beyond puberty

van Ginkel, R., Reitsma, J. B., Büller, H. A., van Wijk, M. P., Taminiau, J. A. J. M., & Benninga, M. A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00888-6 · Cited by 377 · see citing works

The burden of constipation on quality of life: results of a multinational survey

Wald, A. M., Scarpignato, C., Kamm, M. A., Mueller‐Lissner, S., HELFRICH, I., Schuijt, C., Bubeck, J., Limoni, C., & Petrini, O. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03376.x · Cited by 374 · see citing works

Two randomized trials of linaclotide for chronic constipation

Lembo, A. J., Schneier, H. A., Shiff, S. J., Kurtz, C. B., MacDougall, J. E., Jia, X. D., Shao, J. Z., Lavins, B. J., Currie, M. G., Fitch, D. A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1010863 · Cited by 373 · see citing works

ACG Clinical Guideline: Management of Benign Anorectal Disorders

Wald, A. M., Bharucha, A. E., Cosman, B. C., & Whitehead, W. E. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.190 · Cited by 365 · see citing works

Obstructive Defecation: A Failure of Rectoanal Coordination

Rao, S. S. C., Welcher, K., & Leistikow, J. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00326.x · Cited by 364 · see citing works

Anorectal Disorders

Rao, S. S. C., Bharucha, A., Chiarioni, G., Felt-Bersma, R., Knowles, C., Malcolm, A., & Wald, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.009 · Cited by 364 · see citing works

Investigation of Colonic and Whole-Gut Transit With Wireless Motility Capsule and Radiopaque Markers in Constipation

Rao, S. S. C., Kuo, B., McCallum, R. W., Chey, W. D., DiBaise, J. K., Hasler, W. L., Koch, K. L., Lackner, J. M., Miller, C., Saad, R. J., et al. (2009) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2009.01.017 · Cited by 345 · see citing works

The pelvic floor musculature in the descending perineum syndrome

Henry, M. M., Parks, A. G., & Swash, M. (1982) · British journal of surgery · doi:10.1002/bjs.1800690813 · Cited by 328 · see citing works

Lactulose versus Polyethylene Glycol for Chronic Constipation

Lee‐Robichaud, H., Thomas, K., Morgan, J. L., & Nelson, R. L. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007570.pub2 · Cited by 325 · see citing works

Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome

Bijkerk, C. J., Muris, J. W. M., Knottnerus, J. A., Hoes, A. W., & de Wit, N. J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.0269-2813.2004.01862.x · Cited by 325 · see citing works

Randomized, Controlled Trial Shows Biofeedback to be Superior to Alternative Treatments for Patients with Pelvic Floor Dyssynergia-Type Constipation

Heymen, S., Scarlett, Y. V., Jones, K., Ringel, Y., Drossman, D. A., & Whitehead, W. E. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0814-9 · Cited by 321 · see citing works

AGA technical review on constipation

Locke, G., Pemberton, J. H., & Phillips, S. F. (2000) · Gastroenterology · doi:10.1053/gast.2000.20392 · Cited by 320 · see citing works

Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial

Bijkerk, C. J., de Wit, N. J., Muris, J. W. M., Whorwell, P. J., Knottnerus, J. A., & Hoes, A. W. (2009) · BMJ · doi:10.1136/bmj.b3154 · Cited by 312 · see citing works

Manometric Tests of Anorectal Function in Healthy Adults

Rao, S. S. C., Hatfield, R., Soffer, E., Rao, S., Beaty, J. S., & Conklin, J. L. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00950.x · Cited by 307 · see citing works

Untitled work

(1997) · PubMed · Cited by 296 · see citing works

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

Castro, J., Harrington, A. M., Hughes, P. A., Martin, C. M., Ge, P., Shea, C. M., Jin, H., Jacobson, S., Hannig, G., Mann, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.017 · Cited by 295 · see citing works

Predictive value of the balloon expulsion test for excluding the diagnosis of pelvic floor dyssynergia in constipation

Mínguez, M., Herreros, B., Sánchiz, V., Hernández, V., Almela, P., Añón, R., Mora, F., & Benages, A. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.044 · Cited by 285 · see citing works

Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus)

Rao, S. S. C., Mudipalli, R. S., Stessman, M., & Zimmerman, B. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00526.x · Cited by 265 · see citing works

Systematic review: the effects of fibre in the management of chronic idiopathic constipation

Suares, N. C., & Ford, A. C. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04602.x · Cited by 259 · see citing works

Oral bisacodyl is effective and well-tolerated in patients with chronic constipation

Kamm, M. A., Mueller–Lissner, S., Wald, A., Richter, E., Swallow, R., & Gessner, U. (2011) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.03.026 · Cited by 257 · see citing works

American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice

Camilleri, M., Bharucha, A. E., Lorenzo, C. D., Hasler, W. L., Prather, C. M., Rao, S. S. C., & Wald, A. M. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01230.x · Cited by 255 · see citing works

Digital Rectal Examination Is a Useful Tool for Identifying Patients With Dyssynergia

Tantiphlachiva, K., Rao, P., Attaluri, A., & Rao, S. S. C. (2010) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2010.06.031 · Cited by 254 · see citing works

Overlap of gastrointestional symptom complexes in a US community

Locke, G., Zinsmeister, A., Fett, S., Melton, L., & Talley, N. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00581.x · Cited by 254 · see citing works

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253 · see citing works

Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity

Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248 · see citing works

American Gastroenterological Association medical position statement on anorectal testing techniques

Barnett, J. L., Hasler, W. L., & Camilleri, M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70194-0 · Cited by 246 · see citing works

Do Stool Form and Frequency Correlate With Whole-Gut and Colonic Transit? Results From a Multicenter Study in Constipated Individuals and Healthy Controls

Saad, R. J., Rao, S. S. C., Koch, K. L., Kuo, B., Parkman, H. P., McCallum, R. W., Sitrin, M. D., Wilding, G. E., Semler, J. R., & Chey, W. D. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.612 · Cited by 242 · see citing works

Chronic constipation

Bharucha, A. E., & Wald, A. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.031 · Cited by 238 · see citing works

Efficacy of Linaclotide for Patients With Chronic Constipation

Lembo, A. J., Kurtz, C. B., MacDougall, J. E., Lavins, B. J., Currie, M. G., Fitch, D. A., Jeglinski, B. I., & Johnston, J. M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.050 · Cited by 234 · see citing works

Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility

Ge, X., Zhao, W., Ding, C., Tian, H., Xu, L., Wang, H., Ni, L., Jiang, J., Gong, J., Zhu, W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00612-y · Cited by 232 · see citing works

Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double‐blind, placebo‐controlled, dose‐ranging study to evaluate efficacy and safety

Johanson, J. F., & Ueno, R. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03320.x · Cited by 230 · see citing works

Evacuation proctography: An investigation of rectal expulsion in 20 subjects without defecatory disturbance

Bartram, C. I., Turnbull, G. K., & Lennard-Jones, J. E. (1988) · Abdominal Imaging · doi:10.1007/bf01889028 · Cited by 225 · see citing works

Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation

Mueller-Lissner, S., Kamm, M. A., Wald, A., Hinkel, U., Koehler, U., Richter, E., & Bubeck, J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.41 · Cited by 218 · see citing works

A randomized, multicenter, placebo-controlled trial of polyethylene glycol laxative for chronic treatment of chronic constipation

DiPalma, J. A., Cleveland, M. V., McGowan, J., & Herrera, J. L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01199.x · Cited by 217 · see citing works

Biofeedback provides long term benefit for patients with intractable, slow and normal transit constipation

Chiotakakou-Faliakou, E., Kamm, M. A., Roy, A. J., Storrie, J. B., & Turner, I. C. (1998) · Gut · doi:10.1136/gut.42.4.517 · Cited by 209 · see citing works

Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation

Grossi, U., Carrington, E. V., Bharucha, A. E., Horrocks, E. J., Scott, S. M., & Knowles, C. H. (2015) · Gut · doi:10.1136/gutjnl-2014-308835 · Cited by 205 · see citing works

Inability of the Rome III Criteria to Distinguish Functional Constipation From Constipation-Subtype Irritable Bowel Syndrome

Wong, R. K., Palsson, O. S., Turner, M. J., Levy, R. L., Feld, A. D., von Korff, M., & Whitehead, W. E. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.200 · Cited by 204 · see citing works

How well does stool form reflect colonic transit?

Degen, L., & Phillips, S. (1996) · Gut · doi:10.1136/gut.39.1.109 · Cited by 201 · see citing works

Psyllium is superior to docusate sodium for treatment of chronic constipation

Mcrorie, Daggy, Morel, Diersing, Miner, & Robinson (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00336.x · Cited by 200 · see citing works

The Physiology of Human Defecation

Palit, S., Lunniss, P. J., & Scott, S. M. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2071-1 · Cited by 193 · see citing works

Phenotypic Identification and Classification of Functional Defecatory Disorders Using High-Resolution Anorectal Manometry

Ratuapli, S. K., Bharucha, A. E., Noelting, J., Harvey, D. M., & Zinsmeister, A. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.10.049 · Cited by 189 · see citing works

Sacral nerve stimulation induces pan‐colonic propagating pressure waves and increases defecation frequency in patients with slow‐transit constipation

Dinning, P. G., Fuentealba, S. E., Kennedy, M. L., Lubowski, D. Z., & Cook, I. J. (2006) · Colorectal Disease · doi:10.1111/j.1463-1318.2006.01096.x · Cited by 186 · see citing works

How to Perform and Interpret a High-resolution Anorectal Manometry Test

Lee, T. H., & Bharucha, A. E. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15168 · Cited by 186 · see citing works

Efficacy of a Chinese Herbal Proprietary Medicine (Hemp Seed Pill) for Functional Constipation

Cheng, C. W., Bian, Z., Zhu, L.-X., Wu, J. C., & Sung, J. J. �. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.305 · Cited by 174 · see citing works

Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation

Attaluri, A., Donahoe, R., Valestin, J., Brown, K., & Rao, S. S. C. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04594.x · Cited by 174 · see citing works

Review article: anthranoid laxatives and their potential carcinogenic effects

van Gorkom, B. A. P., de Vries, E. G. E., Karrenbeld, & KLEIBEUKER (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00468.x · Cited by 172 · see citing works

Defecography and proctography

Agachan, F., Pfeifer, J., & Wexner, S. D. (1996) · Diseases of the Colon & Rectum · doi:10.1007/bf02053989 · Cited by 171 · see citing works

Efficacy of Secretagogues in Patients With Irritable Bowel Syndrome With Constipation: Systematic Review and Network Meta-analysis

Black, C. J., Burr, N. E., Quigley, E. M. M., Moayyedi, P., Houghton, L. A., & Ford, A. C. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.021 · Cited by 166 · see citing works

Cost-effective treatment of constipation in the elderly: a randomized double-blind comparison of sorbitol and lactulose

Lederle, F. A., Busch, D. L., Mattox, K. M., West, M. J., & Aske, D. M. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90177-f · Cited by 163 · see citing works

Validation of the Balloon Evacuation Test: Reproducibility and Agreement With Findings From Anorectal Manometry and Electromyography

Chiarioni, G., Kim, S. M., Vantini, I., & Whitehead, W. E. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.03.013 · Cited by 161 · see citing works

Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review

Adelstein, B., Macaskill, P., Chan, S. F., Katelaris, P., & Irwig, L. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-65 · Cited by 161 · see citing works

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P. G., Lorenzo, C. D., Huizinga, J. D., Jiménez, M., Rao, S. S. C., et al. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0167-1 · Cited by 161 · see citing works

Comparison of efficacy of pharmacological treatments for chronic idiopathic constipation: a systematic review and network meta-analysis

Nelson, A. D., Camilleri, M., Chirapongsathorn, S., Vijayvargiya, P., Valentin, N., Shin, A., Erwin, P. J., Wang, Z., & Murad, M. H. (2016) · Gut · doi:10.1136/gutjnl-2016-311835 · Cited by 159 · see citing works

Physiology of Refractory Chronic Constipation

Mertz, H., Naliboff, B. D., & Mayer, E. A. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.922_a.x · Cited by 154 · see citing works

Biofeedback Is Superior to Electrogalvanic Stimulation and Massage for Treatment of Levator Ani Syndrome

Chiarioni, G., Nardo, A., Vantini, I., Romito, A., & Whitehead, W. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.040 · Cited by 154 · see citing works

Update of Tests of Colon and Rectal Structure and Function

Bharucha, A. E. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000196190.42296.a9 · Cited by 148 · see citing works

Phenotypic Variation in Functional Disorders of Defecation

Bharucha, A. E., Fletcher, J. G., Seide, B., Riederer, S. J., & Zinsmeister, A. R. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.021 · Cited by 147 · see citing works

Rectal Hyposensitivity

Gladman, M. A., Lunniss, P. J., Scott, S. M., & Swash, M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00604.x · Cited by 144 · see citing works

Constipation

Wald, A. M. (2016) · JAMA · doi:10.1001/jama.2015.16994 · Cited by 143 · see citing works

Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort

manabe, N., wong, B. S., camilleri, M., burton, D., mckinzie, S., & zinsmeister, A. R. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01442.x · Cited by 142 · see citing works

A randomized phase III clinical trial of plecanatide, a uroguanylin analog, in patients with chronic idiopathic constipation

Miner, P. B., Koltun, W. D., Wiener, G. J., De La Portilla, M., Prieto, B., Shailubhai, K., Layton, M. B., Barrow, L., Magnus, L., & Griffin, P. H. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.611 · Cited by 141 · see citing works

Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis

Luthra, P., Camilleri, M., Burr, N. E., Quigley, E. M. M., Black, C. J., & Ford, A. C. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30246-8 · Cited by 140 · see citing works

Treatment of chronic constipation with lactulose syrup: Results of a double-blind study

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Treatment Efficacy of Sacral Nerve Stimulation in Slow Transit Constipation: A Two-Phase, Double-Blind Randomized Controlled Crossover Study

Dinning, P. G., Hunt, L., Patton, V. E., Zhang, T. G., Szczesniak, M. M., Gebski, V., Jones, M., Stewart, P., Lubowski, D. Z., & Cook, I. J. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.101 · Cited by 129 · see citing works

SOLITARY-ULCER SYNDROME OF THE RECTUM ITS ASSOCIATION WITH OCCULT RECTAL PROLAPSE

Schweiger, M., & Alexander-Williams, J. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91766-4 · Cited by 121 · see citing works

Symptoms and Physiology in Severe Chronic Constipation

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