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Prevalence of Eosinophilic Esophagitis in the United States

Open access
Dellon, Evan S., Jensen, Elizabeth T., Martin, Christopher F., Shaheen, Nicholas J., Kappelman, Michael D.·2014·Clinical Gastroenterology and Hepatology

Abstract

Background & Aims Eosinophilic esophagitis (EoE) has become a major cause of upper gastrointestinal morbidity in children and adults. However, there are few data on the nationwide prevalence of EoE. We aimed to estimate the prevalence of EoE in the United States (US). Methods We collected health insurance claims from a large database that represented the US commercially insured population. We analyzed data from 2008 through 2011, identifying cases of EoE using a previously validated definition, and calculated a period prevalence using data from 2009 through 2011. EoE was defined as any instance of the ICD-9 code 530.13. We calculated the prevalence of the code in the database and standardized the estimate to the US population. Results Of 35,575,388 individuals in this database, 16,405 had at least 1 code for EoE. The mean age was 33.5 y, 65% were male, 55.8% had dysphagia, and 52.8% had a diagnostic code for at least 1 allergic condition. Among 11,569,217 individuals with continuous insurance coverage between mid-2009 and mid-2011, 6513 had at least one code for EoE. When standardized to the US population, the estimated period prevalence of EoE was 56.7/100,000 persons, translating to approximately 152,152 cases in the US. Prevalence peaked in men 35–39 y old, with a rate of 114.6/100,000 persons. Conclusions Despite its relatively recent description, EoE is frequently diagnosed in the US, with an estimated prevalence of 56.7/100,000 persons. This estimate depends on the accuracy of the ICD-9 code, but could be an underestimate, given that knowledge of the code and recognition of EoE are increasing.

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Metadata

Authors
Dellon, E. S., Jensen, E. T., Martin, C. F., Shaheen, N. J., & Kappelman, M. D.
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2014-04
Volume
12
Issue
4
Pages
589-596.e1
ISSN
1542-3565 (ISSN-L)
OpenAlex
W2068699438
Cited by
444
References
28
FWCI
36.22
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Prevalence of Eosinophilic Esophagitis in the United States. https://app.cochat.ai/papers/10.1016/j.cgh.2013.09.008
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Dellon, E. S., Jensen, E. T., Martin, C. F., Shaheen, N. J., & Kappelman, M. D. (2014). Prevalence of Eosinophilic Esophagitis in the United States. Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2013.09.008

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