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Cited by 140Liver Disease Diagnosis and TreatmentUltrasound Imaging and ElastographyAdvanced MRI Techniques and Applications

The DOI matches its Crossref record, with a small difference in title or year; 31 of the 31 references it cites were found in a registry or an index.

Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

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Imajo, Kento, Honda, Yasushi, Kobayashi, Takashi, Nagai, Koki, Ozaki, Anna, Iwaki, Michihiro, Kessoku, Takaomi, Ogawa, Yuji, Takahashi, Hirokazu, Saigusa, Yusuke, Yoneda, Masato, Kirikoshi, Hiroyuki, Utsunomiya, Daisuke, Aishima, Shinichi, Saito, Satoru, Nakajima, Atsushi·2022·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2020.12.016
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Abstract

BACKGROUND & AIMS: As alternatives to the expensive liver biopsy for assessing liver fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD), we directly compared the diagnostic abilities of magnetic resonance elastography (MRE), vibration-controlled transient elastography (VCTE), and two-dimensional shear wave elastography (2D-SWE). METHODS: Overall, 231 patients with biopsy-proven NAFLD were included. Intra- and inter-observer reproducibility was analyzed using intraclass correlation coefficient in a sub-group of 70 participants, in whom liver stiffness measurement (LSM) was performed by an elastography expert and an ultrasound expert who was an elastography trainee on the same day. RESULTS: Valid LSMs were obtained for 227, 220, 204, and 201 patients using MRE, VCTE, 2D-SWE, and all three modalities combined, respectively. Although the area under the curve did not differ between the modalities for detecting stage ≥1, ≥2, and ≥3 liver fibrosis, it was higher for MRE than VCTE and 2D-SWE for stage 4. Sex was a significant predictor of discordance between VCTE and liver fibrosis stage. Skin-capsule distance and the ratio of the interquartile range of liver stiffness to the median were significantly associated with discordance between 2D-SWE and liver fibrosis stage. However, no factors were associated with discordance between MRE and liver fibrosis stage. Intra- and inter-observer reproducibility in detecting liver fibrosis was higher for MRE than VCTE and 2D-SWE. CONCLUSIONS: MRE, VCTE, and 2D-SWE demonstrated excellent diagnostic accuracy in detecting liver fibrosis in patients with NAFLD. MRE demonstrated the highest diagnostic accuracy for stage 4 detection and intra- and inter-observer reproducibility. UMIN Clinical Trials Registry No. UMIN000031491.

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Crossref · 10.1016/j.cgh.2020.12.016

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Metadata

Authors
Imajo, K., Honda, Y., Kobayashi, T., Nagai, K., Ozaki, A., Iwaki, M., Kessoku, T., Ogawa, Y., Takahashi, H., Saigusa, Y., Yoneda, M., Kirikoshi, H., Utsunomiya, D., Aishima, S., Saito, S., & Nakajima, A.
Affiliations
  • Yokohama City University (JP)
  • Saga University (JP)
  • Yokohama City University Hospital (JP)
Corresponding author
Nakajima, Atsushi
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2022-04
Volume
20
Issue
4
Pages
908-917.e11
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2020.12.016
OpenAlex
W3110769583
Cited by
140
References
31
Citations by year
2026: 24 · 2025: 27 · 2024: 31 · 2023: 20 · 2022: 29
FWCI
10.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Japan Science and Technology Agency
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
non-alcoholic fatty liver disease, liver fibrosis staging, magnetic resonance elastography, vibration-controlled transient elastography, shear wave elastography, liver stiffness measurement, noninvasive fibrosis assessment, observer reproducibility, diagnostic accuracy
MeSH terms
Female, Humans, Liver, Liver Cirrhosis, Male, Reproducibility of Results, Elasticity Imaging Techniques, Non-alcoholic Fatty Liver Disease

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