Weight loss and weight regain in usual clinical practice: results from the TARGET-NASH observational cohort
Open accessAbstract
First-line treatment for nonalcoholic fatty liver disease (NAFLD) focuses on weight loss through lifestyle modifications.1,2 Weight loss ≥5% results in reduction of steatosis and weight loss ≥10% has been associated with improvement in hepatic inflammation and fibrosis.3 The incidence and sustainability of weight loss among patients with NAFLD were estimated and associating factors identified.
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A limited proportion of individuals achieve a weight reduction of > -5%.
“However, a limited proportion of individuals achieve a weight reduction of > -5%. 280,281”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [281]
Cites
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Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228 · see citing works
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492 · see citing works
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012 · see citing works
Four-year weight losses in the Look AHEAD study: factors associated with long-term success
Wadden, T. A., Neiberg, R. H., Wing, R. R., Clark, J. M., Delahanty, L. M., Hill, J. O., Krakoff, J., Otto, A., Ryan, D. H., Vitolins, M. Z., et al. (2011) · Obesity · doi:10.1038/oby.2011.230 · Cited by 465 · see citing works
ELEVATED METABOLIC RATES IN OBESITY
James, W. P. T., Bailes, J., Davies, H. L., & Dauncey, M. J. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90300-8 · Cited by 175 · see citing works
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Rinella, M. E., Neuschwander-Tetri, B. A., Siddiqui, M. S., Abdelmalek, M. F., Caldwell, S., Barb, D., Kleiner, D. E., & Loomba, R. (2023) · Hepatology · doi:10.1097/hep.0000000000000323 · Cited by 2,667 · see citing works
Self-citationTacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease
Andreasen, C. R., Andersen, A., & Vilsbøll, T. (2023) · Diabetologia · doi:10.1007/s00125-023-05966-9 · Cited by 44 · see citing works
- Authors
- Malespin, M. H., Barritt, A. S., Watkins, S. E., Schoen, C., Tincopa, M. A., Corbin, K. D., Mospan, A. R., Munoz, B., Trinh, H. N., Weiss, L. M., Reddy, K. R., Loomba, R., Kemmer, N., & Lok, A. S.
- Affiliations
- Tampa General Hospital (US)
- University of North Carolina at Chapel Hill (US)
- Target PharmaSolutions, Inc. (United States) (US)
- University of Michigan (US)
- AdventHealth Orlando (US)
- University of Pennsylvania (US)
- University of California San Diego (US)
- Corresponding author
- Lok, Anna S.
- ORCID
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 20
- Issue
- 10
- Pages
- 2393-2395.e4
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W3122794476
- Cited by
- 75
- References
- 8
- Citations by year
- 2026: 13 · 2025: 26 · 2024: 16 · 2023: 9 · 2022: 6 · 2021: 5
- FWCI
- 6.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Pfizer
- National Science Foundation
- Merck
- National Institutes of Health
- Gilead Sciences
- Boehringer Ingelheim
- Zafgen
- Bristol-Myers Squibb
- Novo Nordisk
- Eli Lilly and Company
- Shire
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- non-alcoholic fatty liver disease, weight loss, weight regain, lifestyle modification, weight loss sustainability, steatosis, liver inflammation, liver fibrosis
- MeSH terms
- Humans, Life Style, Liver, Cohort Studies, Weight Gain, Weight Loss, Non-alcoholic Fatty Liver Disease
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