The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Psychotherapy for Alcohol Use Disorder Is Associated With Reduced Risk of Incident Alcohol-Associated Liver Disease
Open accessAbstract
Background & aims Alcohol-associated liver disease (ALD) is a devastating complication of alcohol use disorder (AUD). Once it develops, ALD is exceedingly difficult to treat; it therefore is critical to identify ways to prevent ALD. By treating the causes of increased alcohol consumption, psychotherapy may offer prophylactic benefit against the development of ALD for patients with AUD.Methods In this retrospective cohort study, we used International Classification of Diseases, 9th and 10th revision, codes to identify 9635 patients with AUD in the Mass General Brigham Biobank. The mean follow-up period from AUD diagnosis was 9.2 years. We used Cox regression models to generate hazard ratios (HR) for the development of ALD given the receipt or nonreceipt of psychotherapy, adjusting for a range of other contributors including the receipt of medication-assisted treatment.Results In our cohort, 60.4% of patients were men, 83.5% of patients were white, the median age was 57.0 years, and 3544 patients (36.8%) received psychotherapy. ALD developed in 1135 patients (11.8%). In multivariable analysis, psychotherapy was associated with a reduced rate of ALD (HR, 0.59; 95% CI, 0.50-0.71; P < .001). This association held for both individual psychotherapy (HR, 0.70; 95% CI, 0.56-0.86; P < .001) and group psychotherapy (HR, 0.76; 95% CI, 0.61-0.94; P = .01). Among patients with cirrhosis, psychotherapy was associated with a lower rate of hepatic decompensation (HR, 0.68; 95% CI, 0.48-0.95; P = .03).Conclusions The receipt of psychotherapy in the setting of AUD is associated with reduced incidence and progression of ALD. Given the safety and potential benefit of psychotherapy, clinicians should consider using it to prevent the development of ALD.
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“The treatment of alcohol-associated liver disease should be mainly focused on addressing the underlying etiology, the alcohol use disorder, hence psychotherapy is the backbone of such conditions20”
From Management of depression/anxiety in patients with chronic liver disease (2024) · cites this paper as [20]
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Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study
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Alcohol Consumption in Response to the COVID-19 Pandemic in the United States
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Network support for drinking, Alcoholics Anonymous and long‐term matching effects
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Impact of Alcohol Use Disorder Treatment on Clinical Outcomes Among Patients With Cirrhosis
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Bataller, R., Arab, J. P., & Shah, V. H. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2207599 · Cited by 259
Management of depression/anxiety in patients with chronic liver disease
Garcia-Altieri, M., Carrera-Mejias, K., & Hernaez, R. (2024) · Clinical Liver Disease · doi:10.1097/cld.0000000000000179 · Cited by 11
Metadata
- Authors
- Vannier, A. G. L., Przybyszewski, E. M., Shay, J., Patel, S. J., Schaefer, E., Goodman, R. P., & Luther, J.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Luther, Jay
- ORCID
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 21
- Issue
- 6
- Pages
- 1571-1580.e7
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC9918606
- OpenAlex
- W4294496105
- Cited by
- 38
- References
- 30
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 11 · 2023: 7
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Gastroenterology and Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5T32DK007191-48)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- alcoholism, alcoholic liver disease, psychotherapy, individual psychotherapy, group therapy, alcohol-related liver cirrhosis, hepatic decompensation, medication-assisted treatment, alcohol consumption
- MeSH terms
- Alcohol Drinking, Alcoholism, Female, Humans, Liver Diseases, Alcoholic, Male, Middle Aged, Psychotherapy, Retrospective Studies
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