The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Poly (β-amino ester) s promote cellular uptake of heparin and cancer cell death
Open accessAbstract
Heparin/heparan sulfate-like glycosaminoglycans (HSGAGs) are involved in diverse cellular processes in the extracellular matrix (ECM). The biological effect of HSGAGs depends on disaccharide content and physiological location within the ECM. HSGAGs are also brought into cells during membrane transcytosis and growth factor signaling while protein bound. We sought to probe the impact of free HSGAGs within the cell by using heparin as a model HSGAG. A library of poly(beta-amino ester)s, which internalize DNA, was examined for the capacity of its members to internalize heparin. Fourteen polymers enabled heparin internalization. The most efficacious polymer reduced murine melanoma cell growth by 73%. No glycosaminoglycan was as efficacious as highly sulfated, full-length heparin. Internalized heparin likely interferes with transcription factor function and subsequently induces apoptotic cell death. Therefore, internalized heparin is a novel mechanism for inducing apoptosis of cancer cells.
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“Glycosaminoglycans are sulfated internally and thus induced murine melanoma cell apoptosis by altering transcription [174].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [174]
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Cites
Panyam, J., Zhou, W., Prabha, S., Sahoo, S. K., & Labhasetwar, V. D. (2002) · The FASEB Journal · doi:10.1096/fj.02-0088com · Cited by 1,044
Molecular diversity of heparan sulfate
Esko, J. D., & Lindahl, U. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113530 · Cited by 978
Degradable poly (β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA
Lynn, D. M., & Langer, R. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0015388 · Cited by 924
Self-citationSpecificities of heparan sulphate proteoglycans in developmental processes
Perrimon, N., & Bernfield, M. R. (2000) · Nature · doi:10.1038/35008000 · Cited by 713
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
Pellegrini, L., Burke, D. F., von Delft, F., Mulloy, B., & Blundell, T. L. (2000) · Nature · doi:10.1038/35039551 · Cited by 704
Spivak-Kroizman, T. R., Lemmon, M. A., Đikić, I., Ladbury, J. E., Pinchasi, D., Huang, J., Jaye, M., Crumley, G., Schlessinger, J., & Lax, I. (1994) · Cell · doi:10.1016/0092-8674(94)90032-9 · Cited by 658
Roles of heparan-sulphate glycosaminoglycans in cancer
Sasisekharan, R., Shriver, Z. H., Venkataraman, G., & Narayanasami, U. (2002) · Nature reviews. Cancer · doi:10.1038/nrc842 · Cited by 621
Self-citation(1998) · Elsevier eBooks · doi:10.1016/b978-0-12-186060-8.x5000-1 · Cited by 504
DNA Complexes with Polycations for the Delivery of Genetic Material into Cells
Kabanov, A. V., & Kabanov, V. A. (1995) · Bioconjugate Chemistry · doi:10.1021/bc00031a002 · Cited by 481
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Self-citation
Research works printed but not linked: 1
- Piepkorn, 1983, Heparin effect on DNA synthesis in a murine fibrosarcoma cell line, J. Natl. Cancer Inst., 71, 615
Cited by
Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555
Anticancer Drugs from Marine Flora: An Overview
Boopathy, N. S., & Kathiresan, K. (2010) · Journal of Oncology · doi:10.1155/2010/214186 · Cited by 417
“Internalized sulfated glycosaminoglycans interfere with transcription function and subsequently induce apoptosis of murine melanoma cells [150].”
BackgroundGLYCOMICS APPROACH TO STRUCTURE-FUNCTION RELATIONSHIPS OF GLYCOSAMINOGLYCANS
Sasisekharan, R., Raman, R., & Prabhakar, V. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095745 · Cited by 296
Self-citationPolyketal Nanoparticles: A New pH-Sensitive Biodegradable Drug Delivery Vehicle
Heffernan, M. J., & Murthy, N. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050176w · Cited by 257
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8343-0 · Cited by 246
Self-citation
Metadata
- Authors
- Berry, D., Lynn, D. M., Sasisekharan, R., & Langer, R.
- Affiliations
- Harvard University (US)
- Massachusetts Institute of Technology (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 11
- Issue
- 4
- Pages
- 487-498
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2052116394
- Cited by
- 56
- References
- 42
- Citations by year
- 2023: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL59966, R01HL059966)
- National Cancer Institute (CA52857)
- National Institute of General Medical Sciences (R01GM026698, GM 26698)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- poly(β-amino ester), heparin, cellular uptake, polymer-drug conjugates, melanoma, apoptosis, transcription factor function, extracellular matrix, cancer cell death
- MeSH terms
- Animals, Biological Transport, Cell Division, Cell Line, DNA, Extracellular Matrix, Glycosaminoglycans, Heparin, Humans, Melanoma, Experimental, Polyesters, Time Factors, Molecular Structure, Cell Death, Heparan Sulfate Proteoglycans, Mice
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- Berry, D., Lynn, D. M., Sasisekharan, R., & Langer, R. (2004). Poly (β-amino ester) s promote cellular uptake of heparin and cancer cell death. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2004.03.023
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
