The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations
Open accessAbstract
SUMMARY To understand the adaptation of Mycobacterium tuberculosis to the intracellular environment, we used comprehensive metabolite profiling to identify the biochemical pathways utilized during growth on cholesterol, a critical carbon source during chronic infection. Metabolic alterations observed during cholesterol catabolism centered on propionyl-CoA and pyruvate pools. Consequently, growth on this substrate required the transcriptional induction of the propionyl-CoA assimilating methylcitrate cycle (MCC) enzymes, via the Rv1129c regulatory protein. We show that both Rv1129c and the MCC enzymes are required for intracellular growth in macrophages, and the growth defect of MCC mutants is largely attributable to the degradation of host-derived cholesterol. Together, these observations define a coordinated transcriptional and metabolic adaptation that is required for scavenging carbon during intracellular growth.
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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages
Schnappinger, D., Ehrt, S., Voskuil, M. I., Liu, Y., Mangan, J. A., Monahan, I. M., Dolganov, G., Efron, B., Butcher, P. D., Nathan, C., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030846 · Cited by 1,420
Mycobacterial persistence requires the utilization of host cholesterol
Pandey, A. K., & Sassetti, C. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711159105 · Cited by 1,064
Self-citationAnalysis of the Adult Human Plasma Metabolome
Lawton, K. A., Berger, A., Mitchell, M., Milgram, K. E., Evans, A. M., Guo, L., Hanson, R. W., Kalhan, S. C., Ryals, J. A., & Milburn, M. V. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.4.383 · Cited by 490
Cited by
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
York, A. G., Williams, K. J., Argus, J. P., Zhou, Q. D., Brar, G., Vergnes, L., Gray, E. E., Zhen, A., Wu, N. C., Yamada, D. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.045 · Cited by 461
Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress
Lee, W., VanderVen, B. C., Fahey, R. J., & Russell, D. G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445056 · Cited by 424
The Granuloma in Tuberculosis: Dynamics of a Host–Pathogen Collusion
Ehlers, S., & Schaible, U. E. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00411 · Cited by 342
How sisters grow apart: mycobacterial growth and division
Kieser, K. J., & Rubin, E. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3299 · Cited by 268
Rohde, K. H., Veiga, D. F. T., Caldwell, S., Balázsi, G., & Russell, D. G. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002769 · Cited by 265
Metadata
- Authors
- Griffin, J. E., Pandey, A. K., Gilmore, S. A., Mizrahi, V., Mckinney, J. D., Bertozzi, C. R., & Sassetti, C. M.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 19
- Issue
- 2
- Pages
- 218-227
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2140610868
- Cited by
- 292
- References
- 3
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Griffin, J. E., Pandey, A. K., Gilmore, S. A., Mizrahi, V., Mckinney, J. D., Bertozzi, C. R., & Sassetti, C. M. (2012). Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2011.12.016
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