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The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

York, Autumn G., Williams, Kevin J., Argus, Joseph P., Zhou, Quan D., Brar, Gurpreet, Vergnes, Laurent, Gray, Elizabeth E., Zhen, Anjie, Wu, Nicholas C., Yamada, Douglas H., Cunningham, Cameron R., Tarling, Elizabeth J., Wilks, Moses Q., Casero, David, Gray, David H., Yu, Amy K., Wang, Eric S., Brooks, David G., Sun, Ren, Kitchen, Scott G., Wu, Ting-Ting, Reue, Karen, Stetson, Daniel B., Bensinger, Steven J.·2015·Cell
DOI 10.1016/j.cell.2015.11.045PMC PMC4783382
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  • In previous preclinical studies, inhibition of mTOR or a target downstream of mTOR protected mice from viral RTIs and upregulated IFN-induced antiviral immune responses.

    “In previous preclinical studies, inhibition of mechanistic target of rapamycin (mTOR) or a target downstream of mTOR protected mice from viral RTIs and upregulated IFN-induced antiviral immune responses.8, 9”

    From Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials (2021) · cites this paper as [8]

    The Results section, “Loss of SCAP protects from viral inflection” (page unavailable), reports that macrophage-specific SCAP deletion reduced lung viral load by over 90% after mice were challenged intranasally with MHV-68. “Induction of a type I IFN signature segregates with loss of SREBP2” reports heightened interferon-stimulated genes and antiviral resistance in deficient cells. Our copy does not establish that SCAP or SREBP2 is downstream of mTOR or report protection from direct mTOR inhibition; it also does not describe the mouse challenge specifically as a respiratory tract infection. (LLM, conf=0.84)

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Research works printed but not linked: 40

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Metadata

Authors
York, A. G., Williams, K. J., Argus, J. P., Zhou, Q. D., Brar, G., Vergnes, L., Gray, E. E., Zhen, A., Wu, N. C., Yamada, D. H., Cunningham, C. R., Tarling, E. J., Wilks, M. Q., Casero, D., Gray, D. H., Yu, A. K., Wang, E. S., Brooks, D. G., Sun, R., Kitchen, S. G., Wu, T.-T., Reue, K., Stetson, D. B., & Bensinger, S. J.
Venue
Cell
Publisher
Elsevier BV
Published
2015-12
Volume
163
Issue
7
Pages
1716-1729
ISSN
0092-8674
DOI
10.1016/j.cell.2015.11.045
PMC
PMC4783382
Cited by
461
References
8
Language
en
Licence

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