The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern
Open accessAbstract
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. It is activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that increase cellular ADP:ATP and/or AMP:ATP ratios. Once activated, it switches on catabolic pathways that generate ATP, while switching off biosynthetic pathways and cell cycle progress. These effects suggest that AMPK activators might be useful for treatment and/or prevention of type 2 diabetes and cancer. Indeed, AMPK is activated by the drugs metformin and salicylate, the latter being the major breakdown product of aspirin. Metformin is widely used to treat diabetes, while there is epidemiological evidence that both metformin and aspirin provide protection against cancer. We review the mechanisms of AMPK activation by these and other drugs, and by natural products derived from traditional herbal medicines.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Self-citationResveratrol improves health and survival of mice on a high-calorie diet
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
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Cited by
Konno, H., Konno, K., & Barber, G. N. (2013) · Cell · doi:10.1016/j.cell.2013.09.049 · Cited by 687
Structural basis of AMPK regulation by small molecule activators
Xiao, B., Sanders, M. J., Carmena, D., Bright, N. J., Haire, L. F., Underwood, E., Patel, B. R., Heath, R. B., Walker, P. A., Hallen, S., et al. (2013) · Nature Communications · doi:10.1038/ncomms4017 · Cited by 543
Pinkosky, S. L., Newton, R. S., Day, E. A., Ford, R. J., Lhotak, S., Austin, R. C., Birch, C. M., Smith, B. K., Filippov, S., Groot, P. H. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13457 · Cited by 498
Mäder, P., & Kattner, L. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00960 · Cited by 438
The Concise Guide to PHARMACOLOGY 2013/14: Enzymes
Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 425
Metadata
- Authors
- Hardie, D. G., Ross, F. A., & Hawley, S. A.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 19
- Issue
- 10
- Pages
- 1222-1236
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2059642778
- Cited by
- 372
- References
- 42
- FWCI
- 15.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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