The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Molecular Basis of In Vivo Biofilm Formation by Bacterial Pathogens
Open accessAbstract
Summary Bacterial biofilms are involved in a multitude of serious chronic infections. In recent years, modeling biofilm infection in vitro led to the identification of microbial determinants governing biofilm development. However, we lack information as to whether biofilm formation mechanisms identified in vitro have relevance for biofilm-associated infection. Here, we discuss the molecular basis of biofilm formation using staphylococci and Pseudomonas aeruginosa to illustrate key points, as their biofilm development process is well-studied. We will focus on in-vivo findings such as obtained in animal infection models, and critically evaluate in-vivo relevance of in-vitro findings. Although results on the role of quorum-sensing in biofilm formation have been conflicting, we now argue that integration of in-vitro and in-vivo studies allows a differentiated view of this mechanism as it relates to biofilm infection.
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Cites
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Self-citationd -Amino Acids Trigger Biofilm Disassembly
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Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
McCarthy, H., Rudkin, J. K., Black, N. S., Gallagher, L., O'Neill, E., & O'Gara, J. P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00001 · Cited by 426
Genetic control of bacterial biofilms
Wolska, K. I., Grudniak, A. M., Rudnicka, Z., & Markowska, K. (2016) · Journal of Applied Genetics · doi:10.1007/s13353-015-0309-2 · Cited by 154
Metadata
- Authors
- Joo, H.-S., & Otto, M.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 19
- Issue
- 12
- Pages
- 1503-1513
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W1992774222
- Cited by
- 434
- References
- 10
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
