The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production
Open accessAbstract
Summary The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and to protect cells against a wide range of pro-oxidative insults. As NAC itself is a poor scavenger of oxidants, the molecular mechanisms behind the antioxidative effects of NAC have remained uncertain. Here we show that NAC-derived cysteine is desulfurated to generate hydrogen sulfide, which in turn is oxidized to sulfane sulfur species predominantly within mitochondria. We provide evidence suggesting the possibility that sulfane sulfur species produced by 3-mercaptopyruvate sulfurtransferase and sulfide:quinone oxidoreductase are the actual mediators of the immediate antioxidative and cytoprotective effects provided by NAC.
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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Oxidative stress inhibits distant metastasis by human melanoma cells
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Chemical Biology of H2S Signaling through Persulfidation
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
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Self-citationThe chemistry and biological activities of N-acetylcysteine
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Ferroptosis in health and disease
Berndt, C., Alborzinia, H., Amen, V. S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103211 · Cited by 334
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Metadata
- Authors
- Ezeriņa, D., Takano, Y., Hanaoka, K., Urano, Y., & Dick, T. P.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 25
- Issue
- 4
- Pages
- 447-459.e4
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W2786677683
- Cited by
- 403
- References
- 64
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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